DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad74A and Cdhr2

DIOPT Version :9

Sequence 1:	NP_001246814.1	Gene:	Cad74A / 39936	FlyBaseID:	FBgn0036715	Length:	1820	Species:	Drosophila melanogaster
Sequence 2:	NP_001028536.2	Gene:	Cdhr2 / 268663	MGIID:	2687323	Length:	1308	Species:	Mus musculus

Alignment Length:	1287	Identity:	354/1287 - (27%)
Similarity:	541/1287 - (42%)	Gaps:	246/1287 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPLLLPLFL-SLTAGQLVNQPPQFVPGTGDMSRFSLSENTPVGSPVFQLKGTDPEGGRLKYSIS 64
            :|..|||.|: |:||    |.||.|  |. :|:..:|.|:.|||:..|.|..||.:...|.|.||
Mouse     6 LLCALLPAFMVSVTA----NSPPSF--GV-NMTLVTLPEDLPVGAVAFWLVATDSDNDHLTYGIS 63

  Fly    65 GP---VFSVDRETGVVRLRQELDRETQDTVEVIISITDEGIYGTEPNTVSQRRVIPVRDYNDNQP 126
            ||   .|||:..||.|:|...||.||....::.||.:|    |....| ::.:|| |.|.|||.|
Mouse    64 GPNASYFSVNANTGEVKLASPLDFETVPFFKITISTSD----GLNIRT-AEMQVI-VEDRNDNIP 122

  Fly   127 TFLGRPYTASVSESLPVGSELSVEPPIVVVDRDEGINSEVQM-------KCLEENDICDIFEVRA 184
            .||...::.|::|:||||   ||...::..|:|.|....||.       .....|::..|.|
Mouse   123 VFLNTEFSTSINETLPVG---SVVFSVLAEDKDTGTAGLVQYFIEKVIPSTANSNNLFRILE--- 181

  Fly   185 VKISDGNYTARVALKQQLDFESRPS-YILTISASDSA--LDNR----LSSLATISINVIDIQDQP 242
                    ...:.|...|.:.::.: |.|.:.|.||.  |||:    .|....:||:|||..|..
Mouse   182 --------NGSIVLNDTLSYNNKSAFYQLELKACDSGGILDNKPKTQCSQPVFVSISVIDEPDLD 238

  Fly   243 PIFTNAPYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSLED--EPFGHFELVPFGDPRDGTA 305
            |.|....|||:|.|:...|.|:|||:|||.|.||...:..|:.:  .| |.|::     ..||..
Mouse   239 PRFIREFYSASVAEDATLGTSVLTVEAVDSDKGINDIVTYSVSNSTRP-GWFDI-----REDGVI 297

  Fly   306 VLQTTSEPLDRENAEILQNGGVYVFSIRATEL---IDGAIPAEHSLTRVTIVVTDVDDHQPTFSG 367
            .:..:   ||||.. :|:|..|.: .:.|||.   |.|. .|:.|:. |||.||||:||:|.|
Mouse   298 FVNGS---LDREQL-LLENEEVQI-QVTATEKNLNIYGQ-EAKASMW-VTIRVTDVNDHKPEF-- 353

  Fly   368 PHFNVS------------------ITENLANGMPLPGLSIFVDDRDMGENSRYELSLRDVFNAAR 414
              :|.|                  :.|:.:..:.:.||::...|.|.|:|..:.|||..  ..|.
Mouse   354 --YNCSLPGCSFSPQEAQVNFIGYVDEHASARISIDGLTMVAYDPDQGDNGTFLLSLNG--QDAE 414

  Fly   415 VFEVSPTESQGRTPVVVKVLNASRLDYDVVDPDLRKFEFDLVASVKGVEKAKTR-----VEIHLL 474
            .|.|||..:.|...|.|.|.|:..:||:.        |..:|..|...:.....     |.|||.
Mouse   415 AFNVSPERAAGSVSVQVVVRNSEMVDYEK--------ETVMVVEVVATDSVSNNYSVATVTIHLR 471

  Fly   475 DANDNAPVFDQGTYRFTAAENLPVDAII-GHVKATDLDSGEFGHVRY-VLKGFGADNFYVNPETG 537
            :.||:.|||.|..|..|..|:.|...:: ..::|||||..|:|.:.| :|.|.|||.|.|.|.:|
Mouse   472 NINDHRPVFSQSLYELTVPEHCPTGYLVTDKIQATDLDGDEWGPITYSLLPGNGADLFEVEPNSG 536

  Fly   538 GVYLLKP--LDYEKQSSYSLTVVAIDGGQREANANLFVGVTDVNDNHPNFESKEYSRTIREGAAL 600
            .:.:...  ||.|||:.|.||:.|.|||.:.....|.:.:.|:|||.|         .:|....:
Mouse   537 NLTVKNGTLLDREKQAVYYLTLQATDGGNQSTTTALEITLLDINDNPP---------VVRGSYNV 592

  Fly   601 FEPQ------FFVRAHDADGPSQGNGRVKYSIV----SENSIAGNVFRIEPDTGEIVIQKAARSM 655
            |.|:      ..::|:|.|.|...|..:.:|::    |.|      |.::|:||   :.:....:
Mouse   593 FVPEENGNVSVTIQAYDDDQPDTNNSLLVFSLLPGPYSSN------FSLDPNTG---LLRNLGPL 648

  Fly   656 DTE------RGEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSY 714
            |.|      .|...|.|...|.|.|.||....|.:.|....:..|:|.              .||
Mouse   649 DREAIDPALEGRIVLTVIVADCGEPSLSTNVNVTITVEDINDNLPVFN--------------QSY 699

  Fly   715 RVSIPENAAAGSNVTSVSAHDPD--GLDSLLRYRIVGANDN--------FEIDEISGLITVSPQA 769
            ..|:.|. ..|:.|.:|.|.|.|  ..::.:.:.:.|...|        .|.....|.:.:.|..
Mouse   700 EFSVWER-VPGAWVGTVKAWDADQTAANNRISFSLSGTGANNFILQGNVLEQGWAEGSLWLLPDV 763

  Fly   770 RIDRDSNMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDERPKFEQNS-YATYVSERTAVGES 833
            |:|.:: ...|.:.|:|.:.| |....:|..|.|.|.|:|||.|..:..| .|..|:|..:....
Mouse   764 RLDYET-QKFFHLTVSAENPG-PQGLDSTANVTVTVMDVNDEPPTLDAASLQAISVTENGSEHGQ 826

  Fly   834 VLRVKAIDKDLNSKLEYSMVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVA 898
            |.||.|.|.|..:.|...:|..:.  |||||.:.:..:    ..|.||. :|.:::|.:...|..
Mouse   827 VTRVIAQDVDTAALLRIELVDVIC--TKAGVDVGSVCH----GWFSVDG-NGSVYINQSEAIDYE 884

  Fly   899 AIIIFTVGVR--DLNAEVDPEGQVDTTEVTVYVQSFQDTNPVFKNTGWT---------SSRPVID 952
            |..:.|:.||  |||.:...:.......:.:.::...|..|.|.....|         .::.|..
Mouse   885 ACHLVTLVVRAYDLNTDPGFDAYSSNGSLLINIKDKNDNAPYFLPNNQTFVIIPELVLPNQQVAS 949

  Fly   953 VKIKEEMPIDSALF---ILQAE---DPVTRQPITSFELIEPKQVDYFQVAERTGEVILKKRLDYE 1011
            |:.::|...|:.:.   ||:||   ...|..|:..|.:....:...|     ||.:.|...||..
Mouse   950 VQARDEDSEDNGIIMFSILKAEFVRKDGTSNPVQVFRITRSVEAGLF-----TGSIELVTNLDST 1009

  Fly  1012 ALG------------DTGPEFELQVRAN--SADRQRSTVSRVNITVENVNDNSPRFERNSYQATI 1062
            ..|            ..||..|.|...|  :.|:......:.:.:.|:|..|....:....|||.
Mouse  1010 IQGTYQVTVQAQDQPTLGPALETQTTLNLFTVDQSYRVRLQFSTSKEDVGANMEEIKEALIQATR 1074

  Fly  1063 IENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQGEHAMLFDINNTTGEIIVASGQTIDR 1127
            ..     ..|:.::.:|..|...|......|              |..:|.|...:......|.:
Mouse  1075 TS-----VYVVTIQNIDSTARARASSYMDAY--------------FVFSNGTALTLTELNMMIRK 1120

  Fly  1128 ERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVI 1179
            ::                  ||.:.:::|.:.|:...::.....||..::||
Mouse  1121 DQ------------------DALRQLLQLGLVVVSSQESQEPDQQKLLTSVI 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad74A	NP_001246814.1	Cadherin_repeat	33..124	CDD:206637	36/93 (39%)
		Cadherin_repeat	132..240	CDD:206637	32/121 (26%)
		Cadherin_repeat	249..361	CDD:206637	43/116 (37%)
		Cadherin_repeat	369..479	CDD:206637	32/132 (24%)
		Cadherin_repeat	487..581	CDD:206637	36/97 (37%)
		Cadherin_repeat	589..686	CDD:206637	26/112 (23%)
		Cadherin_repeat	713..810	CDD:206637	27/106 (25%)
		Cadherin_repeat	819..936	CDD:206637	31/119 (26%)
		Cadherin_repeat	953..1049	CDD:206637	25/115 (22%)
		Cadherin_repeat	1057..1166	CDD:206637	16/108 (15%)
		Cadherin_repeat	1175..1279	CDD:206637	2/5 (40%)
		Cadherin_repeat	1293..1390	CDD:206637
		Cadherin_repeat	1402..1513	CDD:206637
		Cadherin_repeat	1523..1628	CDD:206637
Cdhr2	NP_001028536.2	Cadherin_repeat	33..120	CDD:206637	36/92 (39%)
		Cadherin_repeat	128..236	CDD:206637	32/121 (26%)
		Cadherin_repeat	246..349	CDD:206637	43/115 (37%)
		Cadherin_repeat	372..476	CDD:206637	30/113 (27%)
		Cadherin_repeat	485..582	CDD:206637	36/96 (38%)
		Cadherin_repeat	589..691	CDD:206637	26/110 (24%)
		Cadherin_repeat	698..802	CDD:206637	27/106 (25%)
		Cadherin_repeat	815..923	CDD:206637	28/114 (25%)
		Cadherin_repeat	934..1042	CDD:206637	23/112 (21%)
		Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000250\|UniProtKB:Q9BYE9	1178..1308
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1251..1308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12145
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2806
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.960