DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cad74A and Fat2

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_001025159.1 Gene:Fat2 / 245827 MGIID:2685369 Length:4351 Species:Mus musculus


Alignment Length:1839 Identity:464/1839 - (25%)
Similarity:779/1839 - (42%) Gaps:333/1839 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LSLTAGQLVNQPPQFVPGTGDMSRFSLSENTPVGSPV----------------FQLKGTDPEGGR 58
            :|||  |.:::..||   ..|:.|..::||||..:.:                |.|.|||     
Mouse  1956 ISLT--QALDKSLQF---DQDIYRARVTENTPHSNVLVILGVHGNHLNDTLSYFLLNGTD----- 2010

  Fly    59 LKYSISGPVFSVDRETGVVRLR-QELDRETQDTVEVIISITDEGIYGTEPNTVSQRRV-IPVRDY 121
                    :|.:.:..||::.| ...|||.|||.||.:.:.|..:    |..|:|..| :.|.|.
Mouse  2011 --------LFHMVKSAGVLQTRGVTFDREQQDTHEVAVEVRDNRV----PRRVAQALVRVSVEDV 2063

  Fly   122 NDNQPTFLGRPYTASVSESL------------------------------------PVGSELSVE 150
            |||.|.|...||...:.:..                                    |...::|::
Mouse  2064 NDNIPEFQHLPYYTVIQDGTEPGDVLFQVSATDKDLGANGTVTYGFAEDYAYFRIDPYVGDISLK 2128

  Fly   151 PP----------IVVVDRDEG---INSEVQMKCLEENDICDIFE--VRAVKISDG--NYT----- 193
            .|          :.|..||.|   :.:||::.....|....:|:  ...||:.:.  .||     
Mouse  2129 KPFDYQALNKYHLRVTARDAGTPPLQTEVEVHVTVRNKSNPLFQSPYYKVKVPENITLYTPILHT 2193

  Fly   194 -AR----------------------------VALKQQLDFESRPSYILTISASDSALDNRLSSLA 229
             ||                            :.:...||:||:..::.|:.|:|:||.:  .|.|
Mouse  2194 QARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDTALGS--FSEA 2256

  Fly   230 TISINVIDIQDQPPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSLEDEPFGHFEL 294
            |:.:.|.||.|.||.|:...||.:|.|.:||...::.:.|.|.|.|..:::          .:::
Mouse  2257 TVEVLVEDINDNPPTFSQLVYSTSVSEGSPAQTPVIQLLASDQDSGQNQDV----------SYQI 2311

  Fly   295 VPFGDP------RDGTAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTI 353
            |..|..      .:|:.....|.:.||.|..:..:      ..:|||:..|..:..|   |.|.:
Mouse  2312 VEDGSDVSKFFRINGSTGEMFTIQELDYEAHQHFR------VKVRATDRGDPPLTGE---TLVVV 2367

  Fly   354 VVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIFVDDRDMGENSRYELSLRDVFNAARVFEV 418
            .|:|::|:.|.|..|.:..:::|....|..:  |.:...|.|:|:.||.|..:.. .|..|.|.:
Mouse  2368 NVSDINDNPPEFREPQYEANVSELATCGHLV--LKVQALDPDIGDTSRLEYLILS-GNQDRHFSI 2429

  Fly   419 SPTESQGRTPVVVKVLNASRLDYDVVDPDLRKFEFDLVASVKGVEKAKTRVEIHLLDANDNAPVF 483
            :.|..      ::.:.|..:...| ...:||      |.:..||.:|...|.|:..:||..:|.|
Mouse  2430 NSTSG------IISMFNLCKKQLD-SSYNLR------VGASDGVFQATVPVYINTTNANKYSPEF 2481

  Fly   484 DQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRY-VLKGFGADNFYVNPETGGVYLLKPLDY 547
            .|..|....|||..|...:..:.|.|.|||.:|.|.| ::.....:.|::|| :|.:..|:.||.
Mouse  2482 QQNVYEAELAENAKVGTKVIELLAIDKDSGPYGTVDYTIINKLAGERFFINP-SGQITTLQKLDR 2545

  Fly   548 EKQSS--YSLTVVAIDGGQREANANLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAH 610
            |..:.  .::.::|.|||.:.|...:.:.:||.|||.|.|::..|:.:|....:...|...|.|:
Mouse  2546 ENSTERVIAIKIMARDGGGKVAFCTVKIILTDENDNAPQFKASGYTVSIPSNVSRDSPIIQVLAY 2610

  Fly   611 DADGPSQG-NGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTERGEYELVVSATDFGIP 674
            |||   :| |..|.||:.|...:|..:..:.|.||.:.::::...::.:..::.  :.|.|.|.|
Mouse  2611 DAD---EGRNADVTYSVDSTEDLAEEIIEVNPTTGVVKVKESLVGLENKAVDFN--IKAQDGGPP 2670

  Fly   675 PLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVS----IPENAAAGSNVTSVSAHD 735
            ...:.  |.||:.:..|:.|           ||....|.|..|    :||.:..|| |.:|:|.|
Mouse  2671 HWDSL--VPVRLQVVPNEIP-----------LPKFSEPLYTFSASEDLPEGSEIGS-VKAVAAQD 2721

  Fly   736 PDGLDSLLRYRIV-------GANDNFEIDEISGLITVSPQARIDRDS-NMNSFEIIVNAVDSGTP 792
            |      :.|.:|       .::|.|.:|:.:|::.|  :..:|.:| .....:::.:.....|.
Mouse  2722 P------IIYSLVQGTTPESNSDDVFSLDQDTGVLKV--KKAMDHESTKWYQIDLMAHCPHEDTD 2778

  Fly   793 IPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKDLNS--KLEYSMVGP 855
            :  .:..:|.:.|:|:||.||.||.:.|..:::|....|.:|::|.|.|:|..|  ::.|.:   
Mouse  2779 L--VSLVSVNIQVEDVNDNRPVFEADPYKAFLTENMPGGTTVIQVTANDQDTGSDGQVSYRL--- 2838

  Fly   856 VAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDLNAEVDPEGQV 920
                     |:...||  :.:.|.|||:||.|.....|..:......|.|...|....:....| 
Mouse  2839 ---------SVEPGSN--IHQLFAVDSESGWITTLQELDCETQQTYRFYVVAFDHGQTIQLSSQ- 2891

  Fly   921 DTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQPITSFELI 985
              ..|.|.:....|..|.|.:..:..|    .|:..|...:.:.|..|.|:.....:.:|.: :.
Mouse  2892 --ALVEVSITDENDNPPRFASEDYRGS----VVENNEPGELVATLKTLDADISEQNRQVTCY-IT 2949

  Fly   986 EPKQVDYFQVAERTGE--VILKKRLDYEALGDTGPEFELQVRANSADRQRSTVSRVNITVENVND 1048
            |...:..|.:::...|  :..:|.||.|.:.    ::.|::.|:....|.|.  .|.:.|.::||
Mouse  2950 EGDPLGQFSISQVGDEWRITSRKTLDREHIA----KYLLRITASDGKFQASV--PVEVFVLDIND 3008

  Fly  1049 NSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQGEHAMLFDINNT 1113
            |||:..:..|...:.|:......:::|.|:|.|...||        :|.|||.|..|..|.::..
Mouse  3009 NSPQCSQLLYTGKVREDVTPGHFILKVSAIDVDMDTNA--------QITYSLHGPGAQEFKLDPH 3065

  Fly  1114 TGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTV 1178
            |||:...|  .:||||.....|..||.|..|:...|:   |.|.||  |||||||.|.....:..
Mouse  3066 TGELTTLS--VLDRERKDVYNLVAKATDGGGQSCQAE---VTLHIE--DVNDNAPRFFPSHCAVA 3123

  Fly  1179 IPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPY 1243
            :.:|..:.:.|..:.|.|.|:|:..:|.|.|.:  .|:|.|.||..||:|...:.|..:. :...
Mouse  3124 VFDNTTVKTPVAVVFARDPDQGVNAQVVYSLTD--SADGQFSIDATSGVIRLEKPLQVRS-SSAV 3185

  Fly  1244 VLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTENAVTGAPV-FQ 1307
            .|.|||.|.|..:|.. ||.|.|     :..|...|.:|.||:..  ....|.|:|:....| :.
Mouse  3186 ELTVRASDLGTPIPLS-TLGTVT-----VSIVGLEDYLPIFLNSE--HSTQVPEDALIDMEVLYL 3242

  Fly  1308 VIASDPDDESTPSGTITYRILPDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQP 1372
            ...:.|..|.|     .|.|.......: |.:|||:|::....|:|.||...|.:.:|.|.....
Mouse  3243 ATLTRPGSEKT-----GYHITGGNEQGK-FRLDAHTGILYVNGSLDFETNPKYFLSIECSRKSSS 3301

  Fly  1373 KQSATRILQIAILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVI 1437
            ..|....:.|.:.||::|.|||..:.    .::.|.|....|.::...||.|:|...|:.|.|.:
Mouse  3302 SLSDVTTIVINVTDVNEHHPRFTHDL----YTVRVLENAIVGDVILTVSASDDDGPVNSVITYSL 3362

  Fly  1438 IDGNNEQLFTIERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLR 1502
            :.||....|||:.....|.:.|.   :|.||..|::|.|:....|:|..        .:|   ..
Mouse  3363 VGGNQLGHFTIDPKKGKLQVAKA---LDWEQTPSYSLRIRATDSGQPPL--------HED---TE 3413

  Fly  1503 INVRVLDIDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADAEAPPVGLSIENVTFVPQFYKR 1567
            :.|.|:|::||.|:|.|.:.:..::.|.||...|..|...|.|  :|..|        .|.|:: 
Mouse  3414 VAVEVVDVNDNPPRFFQLNYSTAVQENSPIGIKVLQLILDDPD--SPQNG--------PPYFFR- 3467

  Fly  1568 SRSLAVGNLHNLFTLNNRTGELRTGGSFADYVDGYFLMRVMANNSVQPKRQAHSNLKVFVIRDKS 1632
               :..||..::|.: ...|.|.|.||.:.....::.:.:..::|..|...:.:.::|.:.....
Mouse  3468 ---ITEGNTGSVFRV-TPDGWLVTAGSLSRRAQEWYQLHIEVSDSGLPPLSSSTLVRVHITEQSR 3528

  Fly  1633 LLKFVFARPPN--EIQHNIRPFQEQLQKKLKPLGLELHVLDTQVFTRPDMSLDFTATSSCFQMFK 1695
            .       ||:  .::..|...:|:.|..:  :| ::|..|.........|||  ...|..:.|.
Mouse  3529 Y-------PPSTLPLEIFITKGEEEFQGGM--VG-KIHATDRDPQDTLTYSLD--REGSLGKYFT 3581

  Fly  1696 NGAALSFNEMQKLMNSQQL 1714
            .||:..     |::.||.|
Mouse  3582 VGASDG-----KIIASQGL 3595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637 30/108 (28%)
Cadherin_repeat 132..240 CDD:206637 34/194 (18%)
Cadherin_repeat 249..361 CDD:206637 26/117 (22%)
Cadherin_repeat 369..479 CDD:206637 25/109 (23%)
Cadherin_repeat 487..581 CDD:206637 29/96 (30%)
Cadherin_repeat 589..686 CDD:206637 24/97 (25%)
Cadherin_repeat 713..810 CDD:206637 24/108 (22%)
Cadherin_repeat 819..936 CDD:206637 28/118 (24%)
Cadherin_repeat 953..1049 CDD:206637 20/97 (21%)
Cadherin_repeat 1057..1166 CDD:206637 36/108 (33%)
Cadherin_repeat 1175..1279 CDD:206637 30/103 (29%)
Cadherin_repeat 1293..1390 CDD:206637 25/97 (26%)
Cadherin_repeat 1402..1513 CDD:206637 29/110 (26%)
Cadherin_repeat 1523..1628 CDD:206637 22/104 (21%)
Fat2NP_001025159.1 Cadherin_repeat 38..143 CDD:206637
Cadherin_repeat 152..249 CDD:206637
Cadherin_repeat 366..454 CDD:206637
Cadherin_repeat 462..560 CDD:206637
Cadherin_repeat 570..661 CDD:206637
Cadherin_repeat 719..815 CDD:206637
Cadherin_repeat 825..921 CDD:206637
Cadherin_repeat 931..1026 CDD:206637
Cadherin_repeat 1036..1133 CDD:206637
Cadherin_repeat 1141..1238 CDD:206637
Cadherin_repeat 1247..1335 CDD:206637
Cadherin_repeat 1353..1444 CDD:206637
Cadherin_repeat 1452..1551 CDD:206637
Cadherin_repeat 1560..1650 CDD:206637
Cadherin_repeat 1664..1754 CDD:206637
Cadherin_repeat 1762..1867 CDD:206637
Cadherin 1883..1959 CDD:356102 1/2 (50%)
Cadherin_repeat 1972..2066 CDD:206637 30/110 (27%)
Cadherin_repeat 2074..2163 CDD:206637 11/88 (13%)
Cadherin_repeat 2176..2268 CDD:206637 21/93 (23%)
Cadherin_repeat 2276..2375 CDD:206637 26/117 (22%)
Cadherin_repeat 2383..2475 CDD:206637 23/107 (21%)
Cadherin_repeat 2485..2581 CDD:206637 29/96 (30%)
Cadherin_repeat 2590..2683 CDD:206637 25/99 (25%)
Cadherin_repeat 2697..2795 CDD:206637 25/108 (23%)
Cadherin_repeat 2803..2904 CDD:206637 27/117 (23%)
Cadherin_repeat 2913..3009 CDD:206637 21/106 (20%)
Cadherin_repeat 3018..3111 CDD:206637 36/107 (34%)
Cadherin_repeat 3122..3211 CDD:206637 29/97 (30%)
Cadherin_repeat 3226..3319 CDD:206637 25/98 (26%)
Cadherin_repeat 3328..3424 CDD:206637 29/109 (27%)
Cadherin_repeat 3433..3524 CDD:206637 22/105 (21%)
Cadherin_repeat 3544..3621 CDD:206637 16/62 (26%)
Laminin_G_2 3802..3920 CDD:366983
EGF_CA 3953..3986 CDD:238011
EGF 3992..4022 CDD:333761
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4313..4340
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24026
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

Return to query results.
Submit another query.