DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and Cdh23

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:XP_017169419.1 Gene:Cdh23 / 22295 MGIID:1890219 Length:3361 Species:Mus musculus


Alignment Length:1787 Identity:522/1787 - (29%)
Similarity:803/1787 - (44%) Gaps:331/1787 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 VPGT-GDMSRFS------------LSENTPVGSPVFQLKGTDPEGGRLKYSISGP----VFSVDR 72
            |||: |.::|..            :||:|||||.|.||...|.:...|.:.:||.    .|:|:.
Mouse    27 VPGSWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLARDMDNDPLVFGVSGEEASRFFAVEP 91

  Fly    73 ETGVVRLRQELDRETQDTVEVIISITD-EGIYGTEPNTVSQRRVIPVRDYNDNQPTFLGRPYTAS 136
            :||||.|||.|||||:....|..|::| :|:       ::::..|.|.|.|||.|||..:||:..
Mouse    92 DTGVVWLRQPLDRETKSEFTVEFSVSDHQGV-------ITRKVNIQVGDVNDNAPTFHNQPYSVR 149

  Fly   137 VSESLPVGSELSVEPPIVVV---DRDEGINSEVQMKCLEENDICDIFEVRAVKISDGNYTARVAL 198
            :.|:.|||:      ||.:|   |.|.|....|.......:....|...|.:          |.:
Mouse   150 IPENTPVGT------PIFIVNATDPDLGAGGSVLYSFQPPSPFFAIDSARGI----------VTV 198

  Fly   199 KQQLDFESRPSYILTISASDSALDNRLSSLATISINVIDIQDQPPIFTNAPYSATVPENTPAGVS 263
            .|:||:|...:|.||::|:|......||:||.::|.:.|:||..|||.|.|||..:.|::|.|.:
Mouse   199 IQELDYEVTQAYQLTVNATDQDKTRPLSTLANLAIIITDMQDMDPIFINLPYSTNIYEHSPPGTT 263

  Fly   264 ILTVKAVDGDVGIPREIFLSLEDEPFGHFELVPFGDPRDGTAVLQTTSEPLDRENAEILQNGGVY 328
            :..:.|||.|.|.||.|..::..   |:...:...|...|...|...   |||||.  |.:.| :
Mouse   264 VRVITAVDQDKGRPRGIGYTIVS---GNTNSIFALDYISGALTLNGL---LDRENP--LYSHG-F 319

  Fly   329 VFSIRATELIDGAIPAEHSLTRV-TIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIFVD 392
            :.:::.|||.|...|::.::|.. .|:|.|::|:.|.|:...::|:|||....|..|| |.|.|.
Mouse   320 ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALP-LFIQVV 383

  Fly   393 DRDMGENSRYELSLRDVFNAARVFEVSPTESQGRTPVVVKVLNASRLDYDVVDPDLRKFEFDLVA 457
            |:|.|.||.:|:.|  |.|.:..|.:|||..||:..:.::|  |..|||:.||    :::|||.|
Mouse   384 DKDEGLNSMFEVYL--VGNNSHHFIISPTSVQGKADIRIRV--AIPLDYETVD----RYDFDLFA 440

  Fly   458 SVKGVEK-AKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRYV 521
            :....:. ...:|:|.|::.|||.|:|.|..|..:..||:.|...:..|.|||.|.|.||.|.|.
Mouse   441 NESVPDHVGYAKVKITLINENDNRPIFSQPLYNVSLYENITVGTSVLTVLATDNDVGTFGEVNYF 505

  Fly   522 LKGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGGQREANANLFVGVTDVNDNHPNFE 586
            ... ..|.|.::.:||.:.|:..||||....::|||:|.|||..|....:.:.|.|||||.|.|:
Mouse   506 FSD-DPDRFSLDKDTGLIMLIARLDYELIQRFTLTVIARDGGGEETTGRVRINVLDVNDNVPTFQ 569

  Fly   587 SKEYSRTIREGAALFEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKA 651
            ...|...:||..........:||.|.|.|.  |..:.||||:.::. |:.|.|....|..|| ..
Mouse   570 KDAYVGALRENEPSVTQLVRLRATDEDSPP--NNLITYSIVNASAF-GSYFDISIYEGYGVI-SV 630

  Fly   652 ARSMDTER---GEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPS 713
            :|.:|.|:   |...|.|.|.|.|.|||.:|..|.:.|             |...:|.|....|:
Mouse   631 SRPLDYEQIPNGLIYLTVMAKDAGNPPLYSTVPVTIEV-------------FDENDNPPTFSKPA 682

  Fly   714 YRVSIPENAAAGSNVTSVSAHDPD-----GLDSLLRYRIVGANDNFEIDEISGLITVSPQARIDR 773
            |.||:.||..||:.|..::|.|.|     |.:|:: |.:.|:: .|.|:..||.||.:  :.:||
Mouse   683 YFVSVLENIMAGATVLFLNATDLDRSREYGQESII-YSLEGSS-QFRINARSGEITTT--SLLDR 743

  Fly   774 DSNMNSFEIIVNAVDSGT-PIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRV 837
            ::. :.:.:||.|||.|. ...:|...||.|.:.||||..|.::...|...:.|.|.....|..|
Mouse   744 ETK-SEYILIVRAVDGGVGHNQKTGIATVNVTLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTV 807

  Fly   838 KAIDKDL--NSKLEYSM------------VG---------------------------------- 854
            .|:|.||  |..|.||:            .|                                  
Mouse   808 VAVDPDLGENGTLVYSIHPPNKFYSLNSTTGKIRTTHVMLDRENPDPVEAELMRKIIVSVTDCGR 872

  Fly   855 -PVAATTKAGVSI------ANRSNYR-----------------LQEAFRVDSQSGEIFVNGTLRH 895
             |:.||:.|.|.:      .|...:|                 :.:...:|...|   :||.:.:
Mouse   873 PPLKATSSATVFVNLLDLNDNDPTFRNLPFVAEILEGTPAGVSVYQVVAIDLDEG---LNGLVSY 934

  Fly   896 DVAA-------IIIFTVGVRDLNAEVDPE-----------------GQVDTTEVTVYVQSFQDTN 936
            .:..       :|..|.||....||:|.|                 .:..|:.:||.|....|..
Mouse   935 RMQVGMPRMDFVINSTSGVVTTTAELDRERIAEYQLRVVASDAGTPTKSSTSTLTVRVLDVNDET 999

  Fly   937 PVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQPITSFELIEPKQVD-YFQVAERTG 1000
            |.|       ...|.:|.:.|::|.:..:..|...|............|....|| .|.|..|..
Mouse  1000 PTF-------FPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITAGNVDGKFSVGYRDA 1057

  Fly  1001 EVILKKRLDYEALG---------DTGPEFELQVRANSADRQRSTVSRVNITVENVNDNSPRFERN 1056
            .|.....||.|...         |.||          ..::|:..:.|.:||.:||||.|.|.::
Mouse  1058 VVRTVVGLDRETTAAYTLVLEAIDNGP----------VGKRRTGTATVFVTVLDVNDNRPIFLQS 1112

  Fly  1057 SYQATIIENRPHPERVIRVRALDKDAVLNARDERLG--YHKIIYSLQGEHAMLFDINNTTGEIIV 1119
            ||:|::.|:.|....:::::|.|.|      :...|  :::|   |.|.|...|.|:..:| :::
Mouse  1113 SYEASVPEDIPEGHSIVQLKATDAD------EGEFGRVWYRI---LHGNHGNNFRIHVGSG-LLM 1167

  Fly  1120 ASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTV-IPENA 1183
            ...:.:||||.....|.::|.:....|   .:|.|.:.:.|.||||.||.|||::|:.: :.|.|
Mouse  1168 RGPRPLDRERNSSHVLMVEAYNHDLGP---MRSSVRVIVYVEDVNDEAPVFTQQQYNRLGLRETA 1229

  Fly  1184 QIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVR 1248
            .|.:.|:.:.|.|.|.|.||.|.|.:::..|  |.|:||..:|||.|...|              
Mouse  1230 GIGTSVIVVRATDKDTGDGGLVNYRILSGAE--GKFEIDESTGLIVTVDYL-------------- 1278

  Fly  1249 AQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYF--------------LSPRVGQMAN----- 1294
                        ...|.|.   |:.:|||.||.|.|              |...| |.:|     
Mouse  1279 ------------DYETKTS---YLMNVSATDGAPPFNQGFCSVYVTLLNELDEAV-QFSNASYEA 1327

  Fly  1295 -VTENAVTGAPVFQVIASDPDDESTPSGTITYRILPDTPDAEA---FVIDAHSGLITTRQSMDRE 1355
             :.||...|..:.:|.|...|:    ...||||....| .|:|   |.|||.:|:||.:..:|||
Mouse  1328 VIMENLALGTEIVRVQAYSIDN----LNQITYRFDAYT-SAQAKALFKIDAITGVITVKGLVDRE 1387

  Fly  1356 TKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNF 1420
            ..|.|.:.: |:|:|.||..:|..:.|.:||.:|:.|||...:|:   ::||.|:.|.|..|...
Mouse  1388 KGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDS---AISVPEDCPVGQRVATV 1448

  Fly  1421 SALDEDLGENAAIDYVIIDGNNEQLFTIERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPG 1485
            .|.|.|.|.|..:.:.:..||....|.|..:|:|:..:...||:|||:::.:.|.:.....|.|.
Mouse  1449 KARDPDAGSNGQVVFSLASGNIAGAFEIITSNDSIGEVFVAKPLDREELDHYILKVVASDRGTPP 1513

  Fly  1486 YKFIGDPYDRQDLSHLRINVRVLDIDDNLPKFEQP-DPTVGIRINVPIDTVVTTLKASDADAEAP 1549
            .|          ..|: :.|.:||::||.|..|.| ...|.:..||...|.|..::|:|.|    
Mouse  1514 RK----------KDHI-LQVTILDVNDNPPVIESPFGYNVSVNENVGGGTSVVQVRATDRD---- 1563

  Fly  1550 PVGLSIENVTFVPQFYKRSRSLAVGNLHNLFTLNNRTGELRTGGSFADYV-DGYFLMRVMANNSV 1613
             :|     :..|..:|     :..||....|.::..:||:.|..:..|.. ..::.:.|...:..
Mouse  1564 -IG-----INSVLSYY-----ITEGNEDMTFRMDRISGEIATRPAPPDRERQNFYHLVVTVEDEG 1617

  Fly  1614 QPKRQAHSNLKVFVIRDKSLLKFVFARPPNEI 1645
            .|...|.:::.|.:: |::....||.:|..|:
Mouse  1618 TPTLSATTHVYVTIV-DENDNAPVFQQPHYEV 1648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637 37/107 (35%)
Cadherin_repeat 132..240 CDD:206637 31/110 (28%)
Cadherin_repeat 249..361 CDD:206637 34/112 (30%)
Cadherin_repeat 487..581 CDD:206637 35/93 (38%)
Cadherin_repeat 589..686 CDD:206637 33/99 (33%)
Cadherin_repeat 713..810 CDD:206637 35/102 (34%)
Cadherin_repeat 819..936 CDD:206637 38/212 (18%)
Cadherin_repeat 953..1049 CDD:206637 24/105 (23%)
Cadherin_repeat 1057..1166 CDD:206637 29/110 (26%)
Cadherin_repeat 1175..1279 CDD:206637 29/104 (28%)
Cadherin_repeat 1293..1390 CDD:206637 35/105 (33%)
Cadherin_repeat 1402..1513 CDD:206637 30/110 (27%)
Cadherin_repeat 1523..1628 CDD:206637 22/105 (21%)
Cdh23XP_017169419.1 Cadherin_repeat 51..137 CDD:206637 36/92 (39%)
Cadherin_repeat 145..240 CDD:206637 31/110 (28%)
Cadherin_repeat 249..353 CDD:206637 34/112 (30%)
Cadherin_repeat 361..463 CDD:206637 40/110 (36%)
Cadherin_repeat 472..564 CDD:206637 35/92 (38%)
Cadherin_repeat 573..674 CDD:206637 35/117 (30%)
Cadherin_repeat 683..781 CDD:206637 36/102 (35%)
Cadherin_repeat 789..893 CDD:206637 19/103 (18%)
Cadherin_repeat 901..997 CDD:206637 16/98 (16%)
Cadherin_repeat 1006..1105 CDD:206637 25/108 (23%)
Cadherin_repeat 1113..1210 CDD:206637 28/109 (26%)
Cadherin_repeat 1225..1315 CDD:206637 32/120 (27%)
Cadherin_repeat 1324..1421 CDD:206637 34/102 (33%)
Cadherin_repeat 1433..1530 CDD:206637 30/107 (28%)
Cadherin_repeat 1540..1637 CDD:206637 23/112 (21%)
Cadherin_repeat 1645..1747 CDD:206637 1/4 (25%)
Cadherin_repeat 1759..1854 CDD:206637
Cadherin_repeat 1862..1962 CDD:206637
Cadherin_repeat 1970..2072 CDD:206637
Cadherin_repeat 2080..2176 CDD:206637
Cadherin_repeat 2187..2296 CDD:206637
Cadherin_repeat 2308..2405 CDD:206637
Cadherin_repeat 2413..2511 CDD:206637
Cadherin_repeat 2520..2614 CDD:206637
Cadherin_repeat 2627..2725 CDD:206637
Cadherin_repeat 2742..2848 CDD:206637
Cadherin_repeat 2857..2958 CDD:206637
Blue background indicates that the domain is not in the aligned region.

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