DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and FAT2

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_001438.1 Gene:FAT2 / 2196 HGNCID:3596 Length:4349 Species:Homo sapiens


Alignment Length:1951 Identity:492/1951 - (25%)
Similarity:792/1951 - (40%) Gaps:402/1951 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 FQLKGTDPEGGRLKYSISGPVFSVDRETGVVRLR-QELDRETQDTVEVIISITDEGIYGTEPNTV 110
            |.|.|||             :|.:.:..||::.| ...|||.|||.|:.:.:.|    ...|..|
Human  2004 FLLNGTD-------------MFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRD----NRTPQRV 2051

  Fly   111 SQRRV-IPVRDYNDNQPTFLGRPYTASVSESLPVGSELSVEPPIVVVDRDEGINSEVQMKCLEEN 174
            :|..| :.:.|.|||.|.|...||...:.:....|..|.   .:...|.|.|.|..|..:..|:.
Human  2052 AQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF---QVSATDEDLGTNGAVTYEFAEDY 2113

  Fly   175 DICDIFEVRAVKISDGNYTARVALKQQLDFESRPSYILTISASDS---ALDNRLSSLATISINVI 236
            ....|          ..|...::||:..|:::...|.|.:.|.|.   :|.:....|.|:.    
Human  2114 TYFRI----------DPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR---- 2164

  Fly   237 DIQDQPPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSLEDEPFGHFELVPFGDPR 301
              ....|:|.:..|...||||......||..:|...: |: |.|:..:|:||...|..    |.:
Human  2165 --NKSNPLFQSPYYKVRVPENITLYTPILHTQARSPE-GL-RLIYNIVEEEPLMLFTT----DFK 2221

  Fly   302 DGTAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFS 366
            .|   :.|.:.|||.|:..      .:||::|||:...|:.    |...|.::|.||:|:.||||
Human  2222 TG---VLTVTGPLDYESKT------KHVFTVRATDTALGSF----SEATVEVLVEDVNDNPPTFS 2273

  Fly   367 GPHFNVSITENLANGMP--LPGLSIFVDDRDMGENS--RYELSLRDVFNAARVFEVSPT------ 421
            ...:..||:|    |:|  .|.:.:...|:|.|.|.  .|:: :.|..:.::.|:::.:      
Human  2274 QLVYTTSISE----GLPAQTPVIQLLASDQDSGRNRDVSYQI-VEDGSDVSKFFQINGSTGEMST 2333

  Fly   422 ------ESQ------------------GRTPVVVKV----------------LNASR-------- 438
                  |:|                  |.|.|||.|                .|.|.        
Human  2334 VQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLV 2398

  Fly   439 LDYDVVDPDLR---KFE-----------------------FDL------------VASVKGVEKA 465
            |....:|||.|   :.|                       |:|            |.:..||.:|
Human  2399 LKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRA 2463

  Fly   466 KTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRY-VLKGFGADN 529
            ...|.|:..:||..:|.|.|..|....|||..|...:..:.|.|.|||.:|.:.| ::....::.
Human  2464 TVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEK 2528

  Fly   530 FYVNPETGGVYLLKPLDYEKQSS--YSLTVVAIDGGQREANANLFVGVTDVNDNHPNFESKEYSR 592
            |.:|| .|.:..|:.||.|..:.  .::.|:|.|||.|.|...:.:.:||.|||.|.|::.||:.
Human  2529 FSINP-NGQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTV 2592

  Fly   593 TIREGAALFEPQFFVRAHDADGPSQG-NGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMD 656
            :|:...:...|...|.|:|||   :| |..|.||:..|: :..:|..|.|.||.:.::.:...::
Human  2593 SIQSNVSKDSPVIQVLAYDAD---EGQNADVTYSVNPED-LVKDVIEINPVTGVVKVKDSLVGLE 2653

  Fly   657 TERGEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPEN 721
            .:  ..:..:.|.|.| ||..|:   ||.|.:....:.:         :||....|.|..|.||:
Human  2654 NQ--TLDFFIKAQDGG-PPHWNS---LVPVRLQVVPKKV---------SLPKFSEPLYTFSAPED 2703

  Fly   722 AAAGSN---VTSVSAHDPDGLDSLLRYRIVGANDN--FEIDEISGLITVSPQARIDRDS-NMNSF 780
            ...||.   |.:|:|.|| .:.||:|.....:|.:  |.:|..:|:|.|  :..:|.:| .:...
Human  2704 LPEGSEIGIVKAVAAQDP-VIYSLVRGTTPESNKDGVFSLDPDTGVIKV--RKPMDHESTKLYQI 2765

  Fly   781 EIIVNAVDSGTPIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKDLN 845
            :::.:.:.:...:   :..:|.:.|.|:||.||.||.:.|...::|...||.||::|.|||||  
Human  2766 DVMAHCLQNTDVV---SLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKD-- 2825

  Fly   846 SKLEYSMVGPVAATTKAGVSIANRSNYRL--------QEAFRVDSQSGEIFVNGTLRHDVAAIII 902
                         |.:.|     :.:|||        .|.|.:||:||.|.....|..:......
Human  2826 -------------TGRDG-----QVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYH 2872

  Fly   903 FTVGVRDLNAEVDPEGQVDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFI 967
            |.|...|....:....|   ..|.|.:....|..|.|.:..:..|    .|:..|...:.:.|..
Human  2873 FHVVAYDHGQTIQLSSQ---ALVQVSITDENDNAPRFASEEYRGS----VVENSEPGELVATLKT 2930

  Fly   968 LQAEDPVTRQPITSFELIEPKQVDYFQVAERTGE--VILKKRLDYEALGDTGPEFELQVRANSAD 1030
            |.|:.....:.:|.: :.|...:..|.:::...|  :..:|.||.|...    ::.|:|.|:...
Human  2931 LDADISEQNRQVTCY-ITEGDPLGQFGISQVGDEWRISSRKTLDREHTA----KYLLRVTASDGK 2990

  Fly  1031 RQRSTVSRVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHK 1095
            .|.|..  |.|.|.:||||||:..:..|...:.|:......:::|.|.|.|...||        :
Human  2991 FQASVT--VEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNA--------Q 3045

  Fly  1096 IIYSLQGEHAMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEV 1160
            |.|||.|..|..|.::..|||:...:  .:||||.....|..||.|..||...|     ::.:.|
Human  3046 ITYSLHGPGAHEFKLDPHTGELTTLT--ALDRERKDVFNLVAKATDGGGRSCQA-----DITLHV 3103

  Fly  1161 LDVNDNAPEFTQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKS 1225
            .|||||||.|.....:..:.:|..:.:.|..:.|.|.|:|...:|.|.|.:..|  |.|.||..:
Human  3104 EDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAE--GHFSIDATT 3166

  Fly  1226 GLISTRRNLTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVG 1290
            |:|...:.|..:.:| |..|.|||.|.|..:|.. ||.|.|     :..|...|.:|.||:..  
Human  3167 GVIRLEKPLQVRPQA-PLELTVRASDLGTPIPLS-TLGTVT-----VSVVGLEDYLPVFLNTE-- 3222

  Fly  1291 QMANVTENAVTGAPVFQVIA-SDPDDESTPSGTITYRILPDTPDAEAFVIDAHSGLITTRQSMDR 1354
            ....|.|:|..|..|.|:.. :.|..|.|     .||::....... |.:||.:|::....|:|.
Human  3223 HSVQVPEDAPPGTEVLQLATLTRPGAEKT-----GYRVVSGNEQGR-FRLDARTGILYVNASLDF 3281

  Fly  1355 ETKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGN 1419
            ||...|.:.:|.|.......|....:.:.|.||::|.|:|.::    |.|..|.|....|.::..
Human  3282 ETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQD----PYSTRVLENALVGDVILT 3342

  Fly  1420 FSALDEDLGENAAIDYVIIDGNNEQLFTIERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEP 1484
            .||.|||...|:.|.|.:|.||....|||......|.:.|.   :||||..|::|.::....|:|
Human  3343 VSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKA---LDREQASSYSLKLRATDSGQP 3404

  Fly  1485 GYKFIGDPYDRQDLSHLRINVRVLDIDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADA--E 1547
            ..      ::..|::     ::|.|::||.|:|.|.:.:..::.|.||.:.|..|..||.|:  .
Human  3405 PL------HEDTDIA-----IQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPEN 3458

  Fly  1548 APPVGLSIENVTFVPQFYKRSRSLAVGNLHNLFTLNNRTGELRTGGSFADYVDGYFLMRVMANNS 1612
            .||....|..                ||..:.|.: ...|.|.|....:.....::.:::.|::|
Human  3459 GPPYSFRITK----------------GNNGSAFRV-TPDGWLVTAEGLSRRAQEWYQLQIQASDS 3506

  Fly  1613 VQPKRQAHSNLKVFVIRDKSL------LKFVFARPPNEIQHNI--------RPFQEQLQKKL--- 1660
            ..|...:.::::|.|......      |:.......:|.|..:        |..|:.|...|   
Human  3507 GIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQDTLTYSLAEE 3571

  Fly  1661 KPLGLELHV-------LDTQVFTRPDMSLDFTATSSCF---------------QMFKNGAALSFN 1703
            :.||....|       :..|...|...|.:.|.:...|               :..:....:.|.
Human  3572 ETLGRHFSVGAPDGKIIAAQGLPRGHYSFNVTVSDGTFTTTAGVHVYVWHVGQEALQQAMWMGFY 3636

  Fly  1704 EM--QKLM-----NSQQLRQELIDIYAAYGVSEVESCSVRRTHAAA------IFAGMLTSAGAWL 1755
            ::  ::|:     |.|:.....:||..|    .:...|::...|.|      :|.|   .:|.:.
Human  3637 QLTPEELVSDHWRNLQRFLSHKLDIKRA----NIHLASLQPAEAVAGVDVLLVFEG---HSGTFY 3694

  Fly  1756 VF--LAALIGLAALVSLCTACCLKKKLKRHSKRSLQASLRTPTEHTATSYSYSMPAVLYSEPIYG 1818
            .|  ||::|                   .||.:.::.|:       ......:||.|    |..|
Human  3695 EFQELASII-------------------THSAKEMEHSV-------GVQMRSAMPMV----PCQG 3729

  Fly  1819 P 1819
            |
Human  3730 P 3730

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637 23/78 (29%)
Cadherin_repeat 132..240 CDD:206637 22/110 (20%)
Cadherin_repeat 249..361 CDD:206637 33/111 (30%)
Cadherin_repeat 369..479 CDD:206637 39/205 (19%)
Cadherin_repeat 487..581 CDD:206637 30/96 (31%)
Cadherin_repeat 589..686 CDD:206637 28/97 (29%)
Cadherin_repeat 713..810 CDD:206637 25/102 (25%)
Cadherin_repeat 819..936 CDD:206637 32/124 (26%)
Cadherin_repeat 953..1049 CDD:206637 23/97 (24%)
Cadherin_repeat 1057..1166 CDD:206637 33/108 (31%)
Cadherin_repeat 1175..1279 CDD:206637 31/103 (30%)
Cadherin_repeat 1293..1390 CDD:206637 26/97 (27%)
Cadherin_repeat 1402..1513 CDD:206637 32/110 (29%)
Cadherin_repeat 1523..1628 CDD:206637 21/106 (20%)
FAT2NP_001438.1 Cadherin_repeat 462..560 CDD:206637
Cadherin_repeat 570..659 CDD:206637
Cadherin_repeat 719..816 CDD:206637
Cadherin_repeat 825..921 CDD:206637
Cadherin_repeat 931..1026 CDD:206637
Cadherin_repeat 1038..1133 CDD:206637
Cadherin_repeat 1141..1238 CDD:206637
Cadherin_repeat 1247..1335 CDD:206637
Cadherin_repeat 1354..1444 CDD:206637
Cadherin_repeat 1453..1551 CDD:206637
Cadherin_repeat 1559..1650 CDD:206637
Cadherin_repeat 1664..1754 CDD:206637
Cadherin_repeat 1762..1867 CDD:206637
Cadherin_repeat 1887..1963 CDD:206637
Cadherin_repeat <1998..2066 CDD:206637 23/78 (29%)
Cadherin_repeat 2074..2163 CDD:206637 21/101 (21%)
Cadherin_repeat 2176..2268 CDD:206637 33/110 (30%)
Cadherin_repeat 2276..2375 CDD:206637 21/103 (20%)
Cadherin_repeat 2383..2475 CDD:206637 16/91 (18%)
Cadherin_repeat 2486..2581 CDD:206637 30/95 (32%)
Cadherin_repeat 2589..2682 CDD:206637 29/102 (28%)
Cadherin_repeat 2696..2793 CDD:206637 26/102 (25%)
Cadherin_repeat 2801..2902 CDD:206637 31/123 (25%)
Cadherin_repeat 2910..3007 CDD:206637 24/107 (22%)
Cadherin_repeat 3016..3109 CDD:206637 33/107 (31%)
Cadherin_repeat 3120..3209 CDD:206637 30/97 (31%)
Cadherin_repeat 3224..3317 CDD:206637 26/98 (27%)
Cadherin_repeat 3325..3422 CDD:206637 32/110 (29%)
Cadherin_repeat 3431..3522 CDD:206637 21/107 (20%)
Cadherin_repeat 3535..3619 CDD:206637 14/83 (17%)
Laminin_G_2 3800..3921 CDD:280389
EGF_CA 3949..3984 CDD:238011
Cadherin_repeat 37..143 CDD:206637
Cadherin_repeat 152..247 CDD:206637
Cadherin_repeat 366..454 CDD:206637
EGF 3990..4020 CDD:278437
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24026
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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