Protein Alignment Cad74A and Cdh12

DIOPT Version :10

• Sequence 1: NP_648973.1
• Gene: Cad74A / 39936
• FlyBaseID: FBgn0036715
• Length: 1820
• Species: Drosophila melanogaster
• Sequence 2: NP_001008420.1
• Gene: Cdh12 / 215654
• MGIID: 109503
• Length: 794
• Species: Mus musculus
• Alignment Length: 708
• Identity: 174/708 - (24%)
• Similarity: 307/708 - (43%)
• Gaps: 137/708 - (19%)

  Fly  1147 TDAKQSVVEL-----------------QIEVL-DVNDNAPEFTQKKYSTVIPENAQIDSFVLQLE 1193
            |:.|::|:.|                 |..|| :...:.|::..|.:|
Mouse    33 TEPKENVIHLSGRRSHFQRVKRGWVWNQFFVLEEYMGSEPQYVGKLHS----------------- 80

  Fly  1194 AVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDNGNQMPK 1258
              |.|:| .|.|:|.|..:| |..:|.||..:|.|...|:|..:.:.. |.|..:|.|...:.|.
Mouse    81 --DLDKG-EGTVKYTLSGDG-AGTVFTIDETTGDIHAIRSLDREEKPF-YTLRAQAVDIETRKPL 140

  Fly  1259 QPTLSTDTDVRIYIGDVSANDGVPYFL-SPRVGQMANVTENAVTGAPVFQVIASDPDDES-TPSG 1321
            :|    :::..|.:.|:  ||..|.|| .|.|   |:|.|.:..||.|.||.|:|.||.: ..|.
Mouse   141 EP----ESEFIIKVQDI--NDNEPKFLDGPYV---ASVPEMSPVGAYVLQVKATDADDPTYGNSA 196

  Fly  1322 TITYRILPDTPDAEAFVIDAHSGLI-TTRQSMDRETKDMYRILLEVSDNGQP--KQSATRILQIA 1383
            .:.|.||...|   .|.||..:|:| |...:||||.|:.|::|::..|.|..  ..:.|.::.|.
Mouse   197 RVVYSILQGQP---YFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTVVNIT 258

  Fly  1384 ILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLFTI 1448
            :.||:|:.|||.:..    ..:.|.|..|.|:.:|...|:|.|.|:||.|:|.|:.|:...||.|
Mouse   259 LTDVNDNPPRFPKSI----FHLKVPESSPVGSAIGRIRAVDPDFGKNAEIEYNIVPGDGGNLFDI 319

  Fly  1449 ERNNESL-AILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVLDIDD 1512
            ..:.::. .|:|.|||:|.|..:::|..::...|..........|:  :|.:.::|:  |||:|:
Mouse   320 VTDEDTQEGIIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPF--KDTATVKIS--VLDVDE 380

  Fly  1513 NLPKFEQPDPTVGIRINVPIDTVVTTLKASDADAEAPPVGLSIENVTFVPQFYKRSRSLAVGNLH 1577
            . |.|.:|..|:.:..:.|:.|::..:.|.|.|..:..|...|:        :|       .:..
Mouse   381 P-PVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFID--------WK-------SDGE 429

  Fly  1578 NLFTLNNRTGELRTGGSFADYVD----GYFLMRVMANNSVQPKRQAHSNLKVFVIRDKSLLKFVF 1638
            :.||::...|.:.|.    :.:|    ..:...::|:....|...:..|:.:.|:   .:.:|
Mouse   430 SYFTIDGTEGTIATN----ELLDRENMAQYNFSIIASKVSNPLLTSKVNILINVL---DVNEF-- 485

  Fly  1639 ARPP-------NEIQHNIRPFQ-----EQLQKKLKPLGLELHV-LDTQVFTRPDMSL-DFTATSS 1689
              ||       ..:..|.:|.|     ..:.:.|.|.|.:... |..:...:|:.:: ||...::
Mouse   486 --PPEISVPYETAVCENAKPGQIIQIVGAVDRDLSPAGQQFSFRLAPEAVIKPNFTVHDFRNNTA 548

  Fly  1690 CFQMFKNGAALSFNEM--------------QKLMNSQQLRQELIDIYAAYGVSEVESCSVRRTHA 1740
            ..:..:||.:....|:              |...|:..:|     :........:.||:|.
Mouse   549 GIETRRNGYSRRQQELYFLPIVIEDSSYPVQSSTNTMTIR-----VCRCDSDGTILSCNVE---- 604

  Fly  1741 AAIFAGMLTSAGAWLVFLAALIGLAALVSLCTACCLKKKLKRHSKRSLQASLRTPTEH 1798
             |||..:..|.||.:..|..::.|.|:|.|..|  |:::.|:.:..:.:..:|....|
Mouse   605 -AIFLPVGLSTGALIAILLCMVILLAIVVLYVA--LRRQRKKDTLMTSKEDIRDNVIH 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad74A	NP_648973.1	Cadherin_repeat	33..124	CDD:206637
		Cadherin_repeat	132..240	CDD:206637
		Cadherin_repeat	249..361	CDD:206637
		Cadherin_repeat	487..581	CDD:206637
		Cadherin_repeat	589..686	CDD:206637
		Cadherin_repeat	713..810	CDD:206637
		Cadherin_repeat	819..936	CDD:206637
		Cadherin_repeat	953..1049	CDD:206637
		Cadherin_repeat	1057..1166	CDD:206637	7/36 (19%)
		Cadherin_repeat	1175..1279	CDD:206637	25/103 (24%)
		Cadherin_repeat	1293..1390	CDD:206637	36/100 (36%)
		Cadherin_repeat	1402..1513	CDD:206637	34/111 (31%)
		Cadherin_repeat	1523..1628	CDD:206637	17/108 (16%)
Cdh12	NP_001008420.1	CA	80..158	CDD:214520	27/105 (26%)
		Cadherin_repeat	164..265	CDD:206637	38/106 (36%)
		Cadherin_repeat	273..380	CDD:206637	33/114 (29%)
		Cadherin_repeat	389..484	CDD:206637	18/116 (16%)
		Cadherin_repeat	492..590	CDD:206637	16/102 (16%)
		CADH_Y-type_LIR	724..783	CDD:460041