DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and CELSR2

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_001399.1 Gene:CELSR2 / 1952 HGNCID:3231 Length:2923 Species:Homo sapiens


Alignment Length:475 Identity:90/475 - (18%)
Similarity:144/475 - (30%) Gaps:171/475 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1062 HEQTTLRILRAKLGPDDLRTQDAAAWLEYFESKAFEQQEAARNGTPKPDASIASKGHLSVSDLLD 1126
            |::...:.:...|.|          |.:.:|....:......|    |.|||   |:....||..
Human   134 HDRGISQAIEENLEP----------WPQAWEESLVDSSPLLHN----PSASI---GNDYFEDLKK 181

  Fly  1127 YINPSHNAKGKESVAAKRKNYILKLKEKSKQSNVSEHLV------------------EIPREKQK 1173
            |.  .|....|||              |.|..:.|.|.|                  .:|::|..
Human   182 YC--FHRTVNKES--------------KVKFVHTSVHGVGHEFVQLAFKAFDLAPPEAVPQQKDP 230

  Fly  1174 EMSEEDTEETGSEEGK---------SSEENHETILAPVEEPPSPPVIE----------------- 1212
            :......:....||||         :.:...:.:||...:.....|.|                 
Human   231 DPEFPTVKYPNPEEGKGVLTLSFALADKIKAKIVLANDPDADRLAVAEKQDSGEWRVFSGNELGA 295

  Fly  1213 -----------DATMDNSN----PITSSDVSTEPQHPDGSEDG-----------WQPVQRPRSAG 1251
                       :...|.||    .:.||.||::.......::|           |.. .|.:..|
Human   296 LLGWWLFTSWKEKNQDQSNLKDTYMLSSTVSSKILRAIALKEGFHFEETLTGFKWMG-NRAQQLG 359

  Fly  1252 SYGRR-MKQRRASIGKV---YTYQKKNVEADI------------DNPLFQ--NATQQNDKYYILK 1298
            ..|:. :.....:||.:   :...|..|.|.:            :..|.|  ||......|:|  
Human   360 DQGKTVLFAFEEAIGYMCCPFVLDKDGVSAAVICAELASFLATKNLSLSQQLNAIYVEYGYHI-- 422

  Fly  1299 KRTASYSSYADHHSPGLTTQGTKFGRKIVKTLAYRVKSTQPSSGNAKTAGE---------TSEED 1354
             .||||....|        |||      ::.|...:::....:...|..|:         |:..|
Human   423 -TTASYFICHD--------QGT------IQNLFGNLRNYDGKNNYPKMCGKFEISAIRDLTTGYD 472

  Fly  1355 GLKTDASSVEPPTLSSTVQSEAYHTKNSVVSL---GKSPSYKEVA--LAPPGSIAKYQVWVPQAE 1414
            ..:.|..:|.|.:.||.:.:..: ....|.::   |..|..|..|  .||||:            
Human   473 DSQPDKKAVLPTSKSSQMITFTF-ANGGVATMRTSGTEPKIKYYAELCAPPGN------------ 524

  Fly  1415 VSD----KQEDDEMEKKTEQ 1430
             ||    |:|.||:....|:
Human   525 -SDPEHLKKELDELVGAIEE 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637
Cadherin_repeat 132..240 CDD:206637
Cadherin_repeat 249..361 CDD:206637
Cadherin_repeat 487..581 CDD:206637
Cadherin_repeat 589..686 CDD:206637
Cadherin_repeat 713..810 CDD:206637
Cadherin_repeat 819..936 CDD:206637
Cadherin_repeat 953..1049 CDD:206637
Cadherin_repeat 1057..1166 CDD:206637 23/121 (19%)
Cadherin_repeat 1175..1279 CDD:206637 25/159 (16%)
Cadherin_repeat 1293..1390 CDD:206637 22/108 (20%)
Cadherin_repeat 1402..1513 CDD:206637 7/33 (21%)
Cadherin_repeat 1523..1628 CDD:206637
CELSR2NP_001399.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 154..198 16/66 (24%)
Cadherin_repeat 185..285 CDD:206637 19/113 (17%)
Cadherin_repeat 293..395 CDD:206637 17/102 (17%)
Cadherin_repeat 404..501 CDD:206637 24/114 (21%)
Cadherin_repeat 509..606 CDD:206637 14/48 (29%)
Cadherin_repeat 614..708 CDD:206637
Cadherin_repeat 716..811 CDD:206637
Cadherin_repeat 819..917 CDD:206637
Cadherin_repeat 925..1019 CDD:206637
Cadherin_repeat 1042..1120 CDD:206637
EGF_CA 1289..1324 CDD:238011
EGF_CA 1333..1366 CDD:238011
LamG 1369..1552 CDD:238058
EGF_CA 1578..1609 CDD:238011
LamG 1618..1767 CDD:238058
EGF_CA 1795..1829 CDD:238011
EGF 1832..1865 CDD:394967
EGF_Lam 1924..1969 CDD:214543
HormR 1972..2034 CDD:214468
GAIN 2051..2289 CDD:465137
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2213..2238
GPS 2315..2368 CDD:197639
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 2319..2369
7tm_GPCRs 2373..2626 CDD:475119
TM helix 1 2376..2400 CDD:320658
TM helix 2 2409..2430 CDD:320658
TM helix 3 2440..2462 CDD:320658
TM helix 4 2481..2497 CDD:320658
TM helix 5 2516..2539 CDD:320658
TM helix 6 2562..2584 CDD:320658
TM helix 7 2588..2613 CDD:320658
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2688..2838
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2854..2888
Blue background indicates that the domain is not in the aligned region.

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