DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and cdh-1

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_497641.2 Gene:cdh-1 / 187783 WormBaseID:WBGene00019994 Length:2779 Species:Caenorhabditis elegans


Alignment Length:2237 Identity:445/2237 - (19%)
Similarity:774/2237 - (34%) Gaps:745/2237 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 MSRFSLSENTPVGSPVFQLKGTDPEGGRLKYSISGP------VFSVDRETGVVRLRQELDRETQD 89
            :::|::.|:..:|:.:..:.|...|....||.:..|      ...||..:|.:.....||.|.:.
 Worm    26 LTKFTVPESAQIGTRIGWISGKREESAAPKYFVVFPDEQTSKFLKVDERSGEISTIAHLDYEKRS 90

  Fly    90 TVEVI-ISITDEGIYGTEPNTVSQRRVIPVRDYNDNQPTFLGRPYTASVSESLPVGSELSVEPPI 153
            ..::: :.:.:.|      .|:.  .::.|.|.|||.|:|..:.....:||...:|:..::.   
 Worm    91 KFDIVAVKVEESG------ETID--ILVEVDDENDNAPSFADQVVKLEISEFAQLGTSFALP--- 144

  Fly   154 VVVDRDEGINSEVQMKCLEENDICDIFEVRAVKISDGNYTARVALKQQLDFESRPSYILTISASD 218
            .|.|.| |...:|....:.:.::.::|::.:.|::: ...|.:.:..|||.|.|..|.|.|.|.|
 Worm   145 TVTDGD-GPKFDVHRFVILQGNVNNVFKLASRKVNE-QLQADLVVNGQLDREFRDKYELLIEAQD 207

  Fly   219 SALDNRLSSLATISINVIDIQDQPPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGIPREIFLS 283
            .....::..| ..||.:||..|..|:|:.:.|:|:|..|...|..::||:|.|.|:|....|...
 Worm   208 GGKPAKIGQL-RCSIEIIDANDNAPVFSRSRYTASVSANISIGSHLITVQATDADIGENSRISYD 271

  Fly   284 LEDE-----------------------PFGHFELV----PFGDPR-DGTAVLQTT-------SEP 313
            ::..                       |....:::    ..|.|. ..:||:..|       |.|
 Worm   272 IKKTSAPSNSNFAISQSGVITTTASLLPASTHDVIVVASDHGSPSLSSSAVVTITVLGSTLSSPP 336

  Fly   314 LD------RENAEILQN---GGV-------------------------------YVFSIRATELI 338
            ||      ..:|.:::|   |.:                               :|:.:....::
 Worm   337 LDIIWLVESNSAHLMENSTLGSIVARVSIAQQYRDTKLRLIGSSALCPQQTDQAHVYLLLLCGIL 401

  Fly   339 DGAIPAEHSLTRV-------------TIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIF 390
            |....:||.|..:             .:.:.|::|:.|.:.....::|:.........|.     
 Worm   402 DRETASEHHLKFLLEKDGQIIIEHPQLLTIGDINDNAPQWHSSQIHISLNRTQGGSRTLT----- 461

  Fly   391 VDDRDMGENSRYELSLRDV------FNAARVF--------------------------------- 416
            ..|.|:|:|.....|:.|.      ....|:|                                 
 Worm   462 AKDPDLGQNGWIRYSVLDTELVSIDKETGRIFVPNTIDCNIGSEIKFRVRAEDGGSPALSTDLQV 526

  Fly   417 --EVSPTESQ--------------GRTPV---VVKVL-------NASRLDYDVVDPD-------- 447
              ::..|||:              ..||:   :|||:       |:.|:.|.:.:.|        
 Worm   527 VADLLDTESKPPQFEKALWQVEIPEDTPIGTCLVKVVANNSQCGNSKRIRYSLQNQDEHLTVDTM 591

  Fly   448 ------LRKFEFD--------LVASVKGVEKAKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPV 498
                  .:.|:|:        ::|:....|.:.:.:.|.|.|.|||.|:|....|..|..|....
 Worm   592 SGTVCIQKTFDFEKQKSYQTTVIATNANSETSTSLISIRLKDVNDNWPIFYPNEYHLTVREGPKP 656

  Fly   499 DAIIGHVKATDLDSGEFGHVRYVLKGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGG 563
            :..:..|.|:|:|||.||.|.|.:.. .:.:|.:||.||.|:..|||   .:..:.|.|.|.|||
 Worm   657 EEPLLVVSASDMDSGTFGEVSYHILS-ESSSFSINPVTGEVFAQKPL---ARGRFHLVVSAKDGG 717

  Fly   564 --QREANANLFVGVTDV------------------------------------------------ 578
              ..|.:||:.:.|.|.                                                
 Worm   718 GQSSENSANIHITVIDKDTKTPQFSRSKYEIRTTEDILPGIAIGSVGAMSKVKYSIYSGDQDHNF 782

  Fly   579 ------------------------------------------------NDNHPNFESKEYSRTIR 595
                                                            |||.|.|.|.....:||
 Worm   783 SIDEDTGKIYVTRYLDADVHDTVLLNIQATLPSGESNQTQVVIFIEDHNDNPPQFSSSLVEISIR 847

  Fly   596 EGAALFEPQFFVRAHDADGPSQGNGRVKYSIVSE---NSIAGNVFRIEPDTGEIVIQKAARSMDT 657
            |...|.||.:.|:|.|.|  .:.||.|:|||:|.   :||..:.|..:..||.::..:|.|:   
 Worm   848 EDLKLHEPFYVVQASDKD--KKKNGEVRYSIISSHPGSSIEIDQFTGQLSTGSLLDYEATRN--- 907

  Fly   658 ERGEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENA 722
                |:|.|.|||.||||.|:...:.:.|....:..|.|...:..||.|             ||:
 Worm   908 ----YKLRVKATDLGIPPRSSNMTLFIHVLDVNDNAPEFEKSWYTMEVL-------------ENS 955

  Fly   723 AAGSNVTSVSAHDPDGLDS-LLRYRIVGANDNFEIDEISGLITVSPQARIDRDSNMNSFEIIVNA 786
            ...:.|..|.|.|.|.|:: .:.|||...::.|.|||..|  .|..:..|||:. ::..:|.:.|
 Worm   956 PPKTIVGKVVARDKDSLENGQIVYRITNGSEYFGIDEKLG--NVYTKRSIDREV-ISHVDISIVA 1017

  Fly   787 VDSGTPIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKDLNSKLEYS 851
            .|.|.| |.::|.:..::|.|:||..|                   |.|.:..|.....|.|..:
 Worm  1018 EDKGVP-PRSSTASARISVLDVNDNPP-------------------SCLSITPIVVPAGSPLSTA 1062

  Fly   852 MVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTL-----RHDVAAIIIFTVGVRDLN 911
            :...||.....|::.:.....:||.:..|...:|::::...|     ||...::|:...||...:
 Worm  1063 IGTIVAMDPDKGLNGSVLYRAQLQSSLFVVKSNGDVYLRRQLNASDERHQRLSVIVSDQGVPRKS 1127

  Fly   912 AEVDPEGQVDTTEVTVYVQS-FQDTNPVFK-----------NTGWTSSRPVIDVKIKEEMPI-DS 963
            .......::......:.:|. ||....:.|           |....||..:...:|.....| :.
 Worm  1128 VVCHVPVRISKGSADIQIQEPFQKYIEIPKSCPTGCRLTTLNATGVSSWLIQSSEISNHFAIREG 1192

  Fly   964 ALFILQAEDPVTRQPITSFELIEPKQVDYFQVAER---TGEVILKKRL----DYEALG------- 1014
            .||::  ..|:.|.|.:...::..|......:..|   :||...|:..    |..::|       
 Worm  1193 VLFMI--SHPIHRPPYSLVIVLSDKNDRQKSIQLRVLASGEAANKEETIRISDSNSIGTKIGRLG 1255

  Fly  1015 -----------------------DTGPEFELQ---------------VRANSADRQRSTVSRVNI 1041
                                   .||....|.               .:.|:.|.....: ||::
 Worm  1256 EKSADGSFFYRFSSEESCPLELDQTGGLLYLADGLRRGDTHNFSCFFEKFNTTDGSAEEM-RVDL 1319

  Fly  1042 TVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQGEHAM 1106
            .:.....:.|||:....:..|.|:.|....:..|.|...|...:....|       :.|..::  
 Worm  1320 EISRTKSDKPRFDTGHLRVNIREDTPTGSIITTVNATVSDDSASPISYR-------FPLLIDN-- 1375

  Fly  1107 LFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDS-PGRPTDAKQSVVELQIEVLDVNDNAPEF 1170
             |.|:..||:|.:.  .|:....||...|.::|..| ||       :.:.:.:.|.||||:.| |
 Worm  1376 -FSIDQFTGDITLI--DTLHWHVTPTYNLIVEAFTSGPG-------TTLLVTVNVDDVNDHTP-F 1429

  Fly  1171 TQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGE--ANGLFKIDTKSGLI----- 1228
            ...:.:.::|.:.:....|.::.|:|.|:  ..|:||.|...|.  |...||||.|||.|     
 Worm  1430 IVSQPTVLLPSSYRKGGMVHRVVAIDLDK--DPEIRYSLKYAGSEVAKEFFKIDEKSGEIFVVES 1492

  Fly  1229 STRRNLTGKGRAHPYVLIVRAQD-----------------NG--------NQMPKQPTLSTDTDV 1268
            |:..:.:..|...|..|.:||.|                 |.        ::..|..|:.:.:..
 Worm  1493 SSALSTSFGGAGLPETLTIRATDLQDLTKFDEQKVLLKASNASRSTWHFFDEQHKDVTILSTSPQ 1557

  Fly  1269 RIYIGDVSANDGVPYFLSP-------RVGQMANVTENAVTGAPVFQVIASDPDD----------- 1315
            ...|..:...:||...|.|       :..::...:.:..||...|.::|...|:           
 Worm  1558 GSQILQLKFQEGVDLQLIPSSPHFELKSSKIVQKSASVATGTQRFTIVAQKDDELDYSTLKIHVE 1622

  Fly  1316 ---------ESTPSGTITY----------RILPD----------TPDAEAFVIDAHSGLITTRQS 1351
                     .||..|.:|.          |||..          ..:|..|.|::.:|.|:. ..
 Worm  1623 PVFTEPPKISSTSCGVVTIEENVGIEDFKRILATGMTEESRFRFQGNAPKFSINSTTGSISV-LP 1686

  Fly  1352 MDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHEPRFAREADAG-PLSMSVREEEPAGT 1415
            :|||....:.:::.::|.|....|.|  :::.:.|.:|::|    :.||. |..:.:.|....|.
 Worm  1687 LDREASQEHLLIIILTDGGSRNDSCT--VRVTVADQNDNKP----QLDASTPSELEIAESSRVGD 1745

  Fly  1416 IVGNFSALDEDLGEN-------------------------------------------------- 1430
            ::..|.|.|.|:|:|                                                  
 Worm  1746 VLHRFRASDMDIGQNGKFSFELLEDSSGSLDLVPETGDLVLRRLSSLQSWKIKLRVVDHGVPGLY 1810

  Fly  1431 ------------------------------------------------AAIDYVIIDGNNEQLFT 1447
                                                            |.:.|.|::||.:..|:
 Worm  1811 VEKNLEISNRNPQTEAKAPLEFLKQTYLSTIDEGLPRGQFIAKLQPELAGLTYSIVEGNIDSAFS 1875

  Fly  1448 IERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVLDIDD 1512
            :    :|..:::|...:|||.:|.::|.:    :|....:.||          .|::|||.:::|
 Worm  1876 V----DSEGVIRTNLELDREILERYSLKV----IGTGSGQQIG----------TRVDVRVNNLND 1922

  Fly  1513 NLPKFEQPDPTVGIRI--NVPIDTVVTTLKASDADAEAP-------------PVGLSIENVTFVP 1562
            |:|.|....|.   |:  |:.:.:.|.|:.|.|.|..||             |...:|:..|   
 Worm  1923 NVPSFPMSKPR---RVPENLRVGSYVATVGAKDVDNLAPLRYFLVSDSSGQTPTHFNIDQFT--- 1981

  Fly  1563 QFYKRSRSLAVGNLH-----NLFTLNNRTGELR-TGGSFADYVDGYFLMRVMANNSVQPKRQAHS 1621
                       |.:|     :...|...|..:: |.|||..:                      :
 Worm  1982 -----------GTIHLTAPLDFEVLPEHTLTIKATDGSFDTF----------------------T 2013

  Fly  1622 NLKVFVIRDKSLLKFVFARPPNEIQHNIRPFQEQL-QKKLKP---------LGLELHVLDTQVFT 1676
            ||.:||               ::|..|...|.:.| |..:.|         ..:|.|.||.:   
 Worm  2014 NLTIFV---------------SDINDNAPTFSKPLYQTTVSPATFSPGQPFAKIEAHDLDAR--- 2060

  Fly  1677 RPDMSLDFT---ATSSCFQMFKNGAAL 1700
               .:|.::   .:||.|::.....||
 Worm  2061 ---GALTYSLGQGSSSIFRVAPESGAL 2084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637 19/97 (20%)
Cadherin_repeat 132..240 CDD:206637 26/107 (24%)
Cadherin_repeat 249..361 CDD:206637 31/199 (16%)
Cadherin_repeat 487..581 CDD:206637 34/191 (18%)
Cadherin_repeat 589..686 CDD:206637 35/99 (35%)
Cadherin_repeat 713..810 CDD:206637 29/97 (30%)
Cadherin_repeat 819..936 CDD:206637 21/122 (17%)
Cadherin_repeat 953..1049 CDD:206637 21/148 (14%)
Cadherin_repeat 1057..1166 CDD:206637 25/109 (23%)
Cadherin_repeat 1175..1279 CDD:206637 30/135 (22%)
Cadherin_repeat 1293..1390 CDD:206637 25/136 (18%)
Cadherin_repeat 1402..1513 CDD:206637 29/208 (14%)
Cadherin_repeat 1523..1628 CDD:206637 23/125 (18%)
cdh-1NP_497641.2 Cadherin_repeat 29..118 CDD:206637 19/96 (20%)
Cadherin_repeat 129..229 CDD:206637 26/105 (25%)
Cadherin_repeat 238..328 CDD:206637 18/89 (20%)
Cadherin_repeat 459..532 CDD:206637 9/77 (12%)
Cadherin_repeat 546..637 CDD:206637 17/90 (19%)
Cadherin_repeat 645..733 CDD:206637 32/91 (35%)
Cadherin_repeat 746..833 CDD:206637 1/86 (1%)
Cadherin_repeat 843..938 CDD:206637 36/103 (35%)
Cadherin_repeat 947..1041 CDD:206637 33/110 (30%)
Cadherin_repeat 1051..1136 CDD:206637 16/84 (19%)
Cadherin_repeat 1337..1426 CDD:206637 25/107 (23%)
Cadherin_repeat 1445..>1515 CDD:206637 24/71 (34%)
Cadherin_repeat 1638..1723 CDD:206637 17/87 (20%)
Cadherin_repeat 1734..1817 CDD:206637 8/82 (10%)
Cadherin_repeat 1836..1923 CDD:206637 20/104 (19%)
Cadherin_repeat 1934..2025 CDD:206637 25/141 (18%)
Cadherin_repeat 2034..2120 CDD:206637 12/57 (21%)
Cadherin_repeat 2135..2226 CDD:206637
Cadherin_repeat 2235..2330 CDD:206637
Cadherin_repeat 2345..2437 CDD:206637
Cadherin_repeat 2446..2534 CDD:206637
Blue background indicates that the domain is not in the aligned region.

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