DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and cdh-8

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_001294412.1 Gene:cdh-8 / 184652 WormBaseID:WBGene00017576 Length:1684 Species:Caenorhabditis elegans


Alignment Length:1909 Identity:443/1909 - (23%)
Similarity:755/1909 - (39%) Gaps:389/1909 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LLLPLFLSLTAGQLVNQPPQFVPGTGDMSRFSLSENTPVGS--PVFQLKGTDPEGGRLKYSISG- 65
            :||.......:.||:.:|          |...:.|:.|||:  ||    ...|:..::   :|| 
 Worm    12 ILLGCLKGTDSAQLLIEP----------SFLLVEEDWPVGTHLPV----TICPKNVKI---LSGD 59

  Fly    66 -----PVFSVDRETGVVRLRQELDRETQDTVEVIISITDEGIYGTEPNTV-----SQRRVIPVR- 119
                 .|..::.....::|...||.:.::.         :|:.|...:.|     ..|..:.|: 
 Worm    60 PASYFTVVKINETCSTLQLNLALDADKENA---------DGLRGQSFSLVIAGPKKSRATLEVQI 115

  Fly   120 -DYNDNQPTFLGRPYTASVSESLPVGSELSVEPPIVVVDRDEGINSEVQMKCLEENDICDIFEVR 183
             |.|||.|.|...|.:..:||:..:|:::.   .:..:|.|.||:...:...  |.|  ..|.:.
 Worm   116 VDVNDNSPQFSNTPSSFEISENAEIGTDIF---KVTTLDPDTGISGISRFSV--EGD--SSFTLA 173

  Fly   184 AVKISDGNYTARVALKQQLDFESRPSYILTISASD-SALDNRLSSLA-TISINVIDIQDQPPIFT 246
            ..|.|.|..:.::.|.::||||.:|.:...|:|.| ....||..::| |::|:|.:..|:||.|.
 Worm   174 KRKCSSGKCSTQLRLAKKLDFEEKPIHTFNITAKDGDPHSNRTHTVAHTVTIHVKNENDEPPKFL 238

  Fly   247 NAPYSATVP--ENTPAGVSILTVKAVDGDVGIPREIFLSLEDEPFGHFELVPFGDPRDGTAVLQT 309
             ..:|...|  ::|..|..|..::|:|.:.|  .||...:::..  |.::    |.:.|..:|  
 Worm   239 -TDFSQVFPIFKSTKPGDIIAKLEAIDVENG--AEIQFGMKENE--HLKI----DSKSGNVLL-- 292

  Fly   310 TSEPLDRENAEIL--------QNGGVYVFSIRATELIDGA-IP--AEH----SLTRVTIVVTDVD 359
              :.|..::|.|.        :||......::...:.|.| :|  ||:    .|....|....:.
 Worm   293 --KKLPTDDALITVELYATSSKNGKSKTVEMKLRLMNDEATLPKIAENQEKPELCEFPIYEAHLI 355

  Fly   360 DHQPTFSGPHFNVSITENLANGMPLPGLSIFVDDRDMGENSRYELSLRDVFNAARVFEVSPTESQ 424
            ....|||.| ..:...:::|...|          |.:|.:..::|::.|.|:             
 Worm   356 QGTGTFSTP-LKIKTLKSMAEEKP----------RLIGGSESFDLNVIDDFH------------- 396

  Fly   425 GRTPVVVKVLNASRLDYDVVDPDLRKFEFDLVASVKGVEKAKTRVEIHLL-DANDNA------PV 482
                |.:|||||.::...|:|....     ||.|..|..:...|....:. .|:..|      |.
 Worm   397 ----VELKVLNAEKVASQVLDSAQL-----LVKSQSGQCRIVLRSAAQMTPKASPIAQKLKIIPK 452

  Fly   483 FDQGTYRFTAAENLPVDAIIGHVKA-TDLDSGEFGHVRYVLKGFGADNFYVNPETGGVYLLKPLD 546
            |::..|:|...||.. ..::|.||. :|      |.|.|.:.|...:.|.::.: |.:..|:|:|
 Worm   453 FEKSEYQFQVVENRE-PTVLGEVKVISD------GPVTYEILGENGEKFQISND-GEIQNLEPID 509

  Fly   547 YEKQSSYSLTVVAIDGGQREANANLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAHD 611
            .|....:.|.|.|.|.......:.|.:.|.|.|||.|.|:.:.|..|:.||.:   .:..:.|.|
 Worm   510 RETYEKFELIVKATDLNGSSGKSQLIIHVKDENDNSPIFDKEHYFITVDEGKS---EKLKITATD 571

  Fly   612 ADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTERGEYELVVSATDFGIPPL 676
            ||  |..||::.|||  :..|......|.|| |.:.|....|.......|..|.|:|:|.|.|..
 Worm   572 AD--SGKNGQIVYSI--DQKIDNLPIDISPD-GMLFIGAIDRENMGNSNEVNLTVTASDSGEPKR 631

  Fly   677 SNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSNVTSVSAHDPDGLDS 741
            |.:..|.:||....:..|:|..             ..|.:.:..|.:.|..:..:.|.|.|....
 Worm   632 SASATVTIRVKDINDNSPVFSN-------------SRYSIPLDANISPGGIIGRLEATDADSTSP 683

  Fly   742 LLRYRIVGANDNFEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSGTPIPETATTTVYVNVK 806
            .........:..|.:.: ||.|..:....:::.:   |.|..|.|.|.|.|:.......|     
 Worm   684 NNYVTYTSGDPKFTVSD-SGEILFTGPGTLEKSA---SLEFNVTAQDGGDPMNSANALVV----- 739

  Fly   807 DINDERP-KFEQNSYATYVSERTAVGESVLRVKAIDKDLNSKLEYSMVGPVAATTKAGVSIANRS 870
             ||:.|. |..:|...|.::.....||     |:..|.||:    .|.|......:|  |....|
 Worm   740 -INEHRSMKSIENELTTQINSNDTGGE-----KSEIKWLNA----GMPGYTYEIIRA--SADGFS 792

  Fly   871 NYRLQEAFRVDSQSGEIFVNGTLRH-DVAAI--IIFTVGVRDLNAEVDPEGQVDTTEVTVYVQSF 932
            :..:.....:||:||.|:   ||:. |.:.:  |...:.:|....||       ..|:.:.|...
 Worm   793 DSEVATWISIDSKSGRIY---TLKKVDPSRVKQIKLHISMRKGKREV-------PVELIINVMDT 847

  Fly   933 QDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQPITSFELIEPKQVDY----- 992
            .|..|::       |.|...:.:.|...:.:.         |...|:...:  |..::.|     
 Worm   848 DDVTPIY-------STPTRKLSVTESATLGTT---------VVDMPVEGIK--EQNEIKYSLKIT 894

  Fly   993 ------FQVAERTGEVILKKRLDYEALGDTGPEFELQVRANSADRQRSTVSRVNITVENVNDNSP 1051
                  .|: :|.|.:.:.|.||:|.........|..|..|....:.|.:    :|:.:.|||.|
 Worm   895 SGPRGKLQI-DRYGTIKIIKSLDFETEQIIKGIVEGMVVKNGKAAKSSFI----LTILDANDNRP 954

  Fly  1052 RFERNS-YQATIIENR--------PHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQGEHAML 1107
            .|:.:| :..:::|:.        |:|      .|.|:|:        ..:..:.||:.|:....
 Worm   955 IFKNSSNFAVSLLESSVLGTVLDLPYP------LATDRDS--------SKFSTLKYSMTGDEGYF 1005

  Fly  1108 -FDINNTTGEIIVASGQTIDRERTPRI-QLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEF 1170
             .|.:|:|..::.    .:|.| |.|: .|.||..|:.||... .:....:.:.|:|||||||..
 Worm  1006 KIDESNSTIRLVA----PLDFE-TQRVHSLSIKCVDNQGREPH-HEVFASVTVTVIDVNDNAPVI 1064

  Fly  1171 TQKKYSTV-IPENAQIDSFVLQLEAVDADEGLGGEVRYEL-VNEGEANGLFKIDTKSGLISTRRN 1233
            .....:.: |.|:||:...|..|...|:||  ||..:.|: ||    :.||:.|:...|:..   
 Worm  1065 HNTDLTHLSIEEDAQVGQVVTVLVISDSDE--GGVQKTEIDVN----STLFRADSDKKLVVI--- 1120

  Fly  1234 LTGKGRAHPYVL-IVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTE 1297
            .:.||.|...:. .|.|.|.|......|..     |.:|....:.::  |..::|:...:....|
 Worm  1121 ASLKGHAGQRICSTVTATDVGGLRATSPYC-----VTVYPAKNTHHN--PLVITPKQNSIHYFDE 1178

  Fly  1298 NAVTGAPV-FQVIASDPDDESTPSGTITYRILPD---TPDAEAFVIDAHSGLITTRQSMDRETKD 1358
            |.|....: .:|:..|.|     .|.:|:|:  |   ..|.:.|.|...:|.:..||:.|.|.|.
 Worm  1179 NIVYDELLKVKVLEEDGD-----IGNVTFRL--DEMFKKDWQMFTIGEINGSLHARQAFDFEKKT 1236

  Fly  1359 MYRILLEVSDNGQPKQSATRI-------LQIAILDVDDHEPRFAREADAGPLSMSVREEEPAGTI 1416
            ::.|          |..|.||       |.|::.|.:|:.|.|.::    .:.::|.|.|.....
 Worm  1237 VHEI----------KILACRINNCTSTHLFISVNDRNDNCPMFPKQ----DVRLTVLENEKGKRQ 1287

  Fly  1417 VGNF-SALDEDL-GENAAIDYVIIDGNNEQLFTIERNNESLAILKTKKPIDREQVESFTLTIKC- 1478
            ||.. :|||.|. .:|..:.|.    .:..||..  ::.:|.||.|....|||..:...::|.. 
 Worm  1288 VGRIPAALDSDFHSDNTKVCYT----TDTPLFFF--SDPTLPILFTNSSFDREHKKQHQISITAY 1346

  Fly  1479 ---LKLGEPGYKFIGDPYDRQDLSHLRIN------VRVLDIDDNLPKFEQP--DPTVGIRINVPI 1532
               |...:|               |..||      :.||||:||.|||.:.  ..|| ::.:|..
 Worm  1347 DCHLSCRDP---------------HKPINGTIVALIDVLDINDNFPKFSEKIYTSTV-VQGHVTT 1395

  Fly  1533 DTVVTTLKASDADAEAPPVGLSIENVTFVPQFYKRSRSLAVGNLHNLFTLNNRTGELRTGGSFAD 1597
            .:.:.|::|:|.|.|  |.||......||     ||.|.:.....:..:::..||||.......|
 Worm  1396 GSHILTVQATDLDEE--PEGLKYSIRGFV-----RSPSHSFVAAESPISIDKSTGELSATEILKD 1453

  Fly  1598 YVDGYFLMRVMANNS------------VQPKRQAHSNLKVFVIRDKSLLKFVFARPPNEIQHNIR 1650
              ..|....|:.:.:            :..:...:::.::.|:......:.||..|...|..|.:
 Worm  1454 --SSYSFTVVVTDGAGHEDTASVVVIDLSYELSTNASFQISVVTYAQQTELVFDAPFELIMKNEK 1516

  Fly  1651 PFQEQLQKKLKPLGLELHVLDTQVFTRPDMSLDFTATSSCFQMFKNGAALSFNEMQKLM--NSQQ 1713
            ...|.|.   ...||:      .:..:...:.:||.....| |..||..::.:....|:  :|.:
 Worm  1517 KIAENLS---NATGLQ------TIVDKCRQNANFTLMLVHF-MDINGQFVNVDRAVNLLMSSSAE 1571

  Fly  1714 LRQELIDIYAAYGVSEVESCSVRRTHAAAIFAGMLTSAGAWLVFLAALIGLAALVSLCTACCLKK 1778
            .|:||..:   ||:.|           |.....:.:....:::....|..:.:::|:|..|..:.
 Worm  1572 SRRELRSV---YGLRE-----------AFPPVPIPSKVPQYILIAVLLFFVISILSMCIWCRQRN 1622

  Fly  1779 KLKRHSKR-SLQASLRTPTEHTAT 1801
            ..:|..:. |.|||    |.||.|
 Worm  1623 NYERKLRHISAQAS----TVHTVT 1642

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637 20/105 (19%)
Cadherin_repeat 132..240 CDD:206637 29/109 (27%)
Cadherin_repeat 249..361 CDD:206637 26/128 (20%)
Cadherin_repeat 369..479 CDD:206637 21/110 (19%)
Cadherin_repeat 487..581 CDD:206637 26/94 (28%)
Cadherin_repeat 589..686 CDD:206637 30/96 (31%)
Cadherin_repeat 713..810 CDD:206637 19/96 (20%)
Cadherin_repeat 819..936 CDD:206637 27/119 (23%)
Cadherin_repeat 953..1049 CDD:206637 18/106 (17%)
Cadherin_repeat 1057..1166 CDD:206637 27/119 (23%)
Cadherin_repeat 1175..1279 CDD:206637 28/106 (26%)
Cadherin_repeat 1293..1390 CDD:206637 27/107 (25%)
Cadherin_repeat 1402..1513 CDD:206637 30/122 (25%)
Cadherin_repeat 1523..1628 CDD:206637 23/116 (20%)
cdh-8NP_001294412.1 Cadherin_repeat <55..121 CDD:206637 13/77 (17%)
Cadherin_repeat 131..232 CDD:206637 28/107 (26%)
Cadherin_repeat 457..544 CDD:206637 26/94 (28%)
Cadherin_repeat 552..647 CDD:206637 32/102 (31%)
Cadherin_repeat 656..741 CDD:206637 18/94 (19%)
Cadherin_repeat 861..952 CDD:206637 18/106 (17%)
Cadherin_repeat 964..1060 CDD:206637 26/115 (23%)
Cadherin_repeat 1184..1265 CDD:206637 24/97 (25%)
Cadherin_repeat 1275..1375 CDD:206637 30/120 (25%)
Cadherin_repeat 1396..1476 CDD:206637 20/88 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 64 1.000 Domainoid score I6761
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46529
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24026
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
44.110

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