DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and fmi-1

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_506256.3 Gene:fmi-1 / 179788 WormBaseID:WBGene00001475 Length:2596 Species:Caenorhabditis elegans


Alignment Length:1136 Identity:313/1136 - (27%)
Similarity:508/1136 - (44%) Gaps:188/1136 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   418 VSPTESQGRTPVVVKVLN-----ASRLDYDVVDPDLRKFEFDLVASVKGVE---KAKTRVEIHLL 474
            |:|.:|:.:....:..::     |..:|.:|:|..:.|     |.:.:.|:   .|.|.|.:|:|
 Worm   202 VAPQDSRSQNLFTLDTMSGEIRLAKSMDREVLDKHILK-----VTAYERVDPTISASTTVVVHVL 261

  Fly   475 DANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRYVL-KGFGADNFYVNPETGG 538
            |..||:|:|::.:|.....|:.|:...:..|.|.||||||.|.:.|.| :|.|.:...:|.::|.
 Worm   262 DVQDNSPIFEKDSYFGEIREDAPIGTTVLSVFARDLDSGENGEIEYSLGEGNGKNLLAINAKSGV 326

  Fly   539 VYLLKPLDYEKQSSYSLTVVAIDGG--QREANANLFVGVTDVNDNHPNFESKEYSRTIREGAALF 601
            :....|||.|..|...|.|:|.|.|  :||:.|.:.:.|.|||||.|.|.|..|:.||.|...:.
 Worm   327 IQTAAPLDRETLSLIRLDVIASDKGTPKRESTAMVEITVVDVNDNAPVFASDSYNVTILENITIP 391

  Fly   602 EPQFFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTERGEYELVV 666
            .....|:|.|.|..:  ||:|.||:.|.:.|.|  ..|:..|||:.:::   .:|.:......|:
 Worm   392 AVIATVKATDEDFGT--NGKVHYSMASSSGIGG--LTIDYSTGEVTLRE---RIDAKNSPITAVI 449

  Fly   667 SATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSNVTSV 731
            .|.|...|.||:|..:.:.| |..|            ::.|.:......:::.||.|.|..|..|
 Worm   450 RAKDGAQPALSSTVPLTINV-IDIN------------DHAPTLIAAQKMITLEENVAIGEEVGRV 501

  Fly   732 SAHDPD-GLDSLLRYRIVGANDNFEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSGTPIPE 795
            .|.|.| |.:.:::|.:.|:.| |.|||.||||..:  ..:||::... :.:.|.|.|.|||...
 Worm   502 YAIDEDSGPNGIIKYSMEGSED-FIIDEDSGLIKTT--KLLDRETTAR-YSLKVTARDMGTPSLN 562

  Fly   796 TATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKDLNSKLEYSMVGPVAATT 860
            | :||:.|.:|||||..|.|::..|...:||....|..::.:||:|.|.:.|:            
 Worm   563 T-STTIAVVLKDINDNAPTFDKKEYNVTISEEMPRGSQIITLKAVDNDEDQKI------------ 614

  Fly   861 KAGVSIANRSNYRLQEAFR-------VDSQSGEIFVNGTLR---HDVAAIIIFTVGVRDLNAEVD 915
                      .||::||.|       :..|...:.|:|.|:   |.|...|..|          |
 Worm   615 ----------TYRIEEADREVFSILDIGDQGAILSVSGELKRQDHKVRVEISAT----------D 659

  Fly   916 PEGQVDTTEVTVYVQSFQDTN--PVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQP 978
            ..|......|.|::   .|.|  |.|.:..::       |||.|..||...:..|:|||......
 Worm   660 QGGLQGRCVVNVFI---DDVNSAPYFNDHPFS-------VKIPEHSPIGYPVITLKAEDHDRGDN 714

  Fly   979 ITSFELIEPKQVDYFQVAERTGEVILKKRLDYEALGDTGPEFELQVRANSADRQRSTVSRVNITV 1043
            ......|:..|  :|::...:|::.:...||.|   |......:...::.|....:|.:::.:.:
 Worm   715 ARIVYSIDSSQ--FFRIDPSSGDISVSSDLDRE---DRATFSVIVTASDHASPPLNTSTQIEVIL 774

  Fly  1044 ENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQGEHA--- 1105
            :::|||||:|..:||.|||.|:.|.....::|.|:|.|         :|.:.|:.....|.:   
 Worm   775 DDINDNSPQFTSSSYAATISEDIPVGTSFLQVSAIDAD---------IGPNGIVDYFLNESSSSP 830

  Fly  1106 --MLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAP 1168
              .||.::.|:|.:.|:|  .:|||:...|.|.|.|.|   |.|.:..:..|:.:.:.|||||||
 Worm   831 SIQLFRLDRTSGTLRVSS--KLDREQFAVIVLPIFARD---RGTPSLSAASEITLTLSDVNDNAP 890

  Fly  1169 EFTQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKID---TKSGL--I 1228
            .|.|..|...|.||:.:.|.|..:.|.|||||...::.:.:....:|. ||.|:   .::|:  |
 Worm   891 TFEQLSYDLYIAENSPVGSTVGTIVARDADEGDNADISFRIFGGADAK-LFDIEEDAEQNGVVRI 954

  Fly  1229 STRRNLTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMA 1293
            .||.....:.:|:.:...::|...        .||:...|||::.||  ||..|......:  :.
 Worm   955 LTRAEFDYEAKANKFFFELQASSG--------QLSSTVPVRIHVSDV--NDNKPALKDFVI--LM 1007

  Fly  1294 NVTENAVTGAPVFQVIASDPDDESTPSGTITYRILPDTPDAEAFVIDAHSGLITTRQSMDRETKD 1358
            |..:|......:..:.|.|||.    :.|:.| .|.:....||   :.::|.|..:|...|....
 Worm  1008 NRFDNVQMARQIGFIPAFDPDQ----NATLEY-FLEENDLIEA---EKYTGKILVKQEWKRNMDV 1064

  Fly  1359 MYRILLEVSDNGQPKQSATRI---------------LQIAILDVDDH-EPR-FAREADAGPLSMS 1406
            .::..  |||....:.|..|.               |.:|.:.|||. :|. |.|..||    ||
 Worm  1065 SFKTC--VSDGANTECSTCRFIHVLVEPEWLSESFTLSLARMTVDDFWDPLVFQRFRDA----MS 1123

  Fly  1407 VREE-EPAGT-IVGNFSALDEDLGENAAI-DY-VIIDGNNEQLFTIERNNESLAILKTKKPIDRE 1467
            .... :|:.. ::|....||:.:..|.|| |: .::.|..    .||...||:..|:....:..|
 Worm  1124 TLSNWKPSDIHVIGVKQHLDDVIYINIAITDHGRVVRGWR----AIELVKESIKKLEKMTLLQVE 1184

  Fly  1468 QV-------ESFTLTIKCLKLGEPGYKFIGD 1491
            .:       |..:...||.:.    .||:|:
 Worm  1185 VIRDESCANEPCSHMAKCRQT----QKFVGE 1211

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637
Cadherin_repeat 132..240 CDD:206637
Cadherin_repeat 249..361 CDD:206637
Cadherin_repeat 369..479 CDD:206637 16/68 (24%)
Cadherin_repeat 487..581 CDD:206637 35/96 (36%)
Cadherin_repeat 589..686 CDD:206637 28/96 (29%)
Cadherin_repeat 713..810 CDD:206637 36/97 (37%)
Cadherin_repeat 819..936 CDD:206637 27/126 (21%)
Cadherin_repeat 953..1049 CDD:206637 21/95 (22%)
Cadherin_repeat 1057..1166 CDD:206637 34/113 (30%)
Cadherin_repeat 1175..1279 CDD:206637 29/108 (27%)
Cadherin_repeat 1293..1390 CDD:206637 24/111 (22%)
Cadherin_repeat 1402..1513 CDD:206637 23/101 (23%)
Cadherin_repeat 1523..1628 CDD:206637
fmi-1NP_506256.3 Cadherin_repeat 170..266 CDD:206637 16/68 (24%)
Cadherin_repeat 274..371 CDD:206637 35/96 (36%)
Cadherin_repeat 379..475 CDD:206637 31/115 (27%)
Cadherin_repeat 486..577 CDD:206637 37/95 (39%)
Cadherin_repeat 686..780 CDD:206637 21/105 (20%)
Cadherin_repeat 788..888 CDD:206637 34/113 (30%)
Cadherin_repeat 896..996 CDD:206637 30/110 (27%)
EGF_CA 1252..1287 CDD:238011
LamG 1333..1504 CDD:238058
LamG 1582..1716 CDD:238058
EGF_CA 1774..1808 CDD:238011
EGF_Lam 1865..1911 CDD:238012
HormR 1917..1974 CDD:214468
GPS 2170..2218 CDD:197639
7tm_GPCRs 2237..2455 CDD:421689
TM helix 2 2258..2284 CDD:410628
TM helix 3 2289..2315 CDD:410628
TM helix 4 2326..2346 CDD:410628
TM helix 5 2356..2383 CDD:410628
TM helix 6 2400..2435 CDD:410628
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
21.870

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