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Protein Alignment Cad74A and cdh-4

DIOPT Version :10

Sequence 1:	NP_648973.1	Gene:	Cad74A / 39936	FlyBaseID:	FBgn0036715	Length:	1820	Species:	Drosophila melanogaster
Sequence 2:	NP_001317871.1	Gene:	cdh-4 / 175590	WormBaseID:	WBGene00000396	Length:	4328	Species:	Caenorhabditis elegans

Alignment Length:	2287	Identity:	472/2287 - (20%)
Similarity:	754/2287 - (32%)	Gaps:	859/2287 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NQPPQFVPGTGDMSRF-SLSENTPVGSPVFQLKGTDPEG---GRLKYSI-----SGPVFSVDRET 74
            |..|||    .::|.: .:|||...|..:|::...|.:|   |::|:|:     ...|.|:|.:|
Worm   715 NHSPQF----DEVSYYLRISENEKPGKDIFKVTANDFDGGNNGKIKFSLGNNQEKSSVISIDAKT 775

  Fly    75 GVVRLRQELDRETQDTVEVIISITDEGIYGTEPNTVSQRRV-IPVRDYNDNQPTFLGRPYTASVS 138
            |:|:|.:.||||.||.....|..:|||.    |..||...: |.|.|.|||.|..:.:...|.:.
Worm   776 GIVKLLKSLDREDQDVHTFAIIASDEGF----PMRVSVTNLTISVEDVNDNPPKCVVQHSRARIP 836

  Fly   139 ESLPVGSELS------------------------------------VEPP--------------- 152
            |.||.|:.:|                                    :..|
Worm   837 EDLPHGAFVSCMAAFDEDIGQNSKLKFLLNSEKVPFRIDHHSGCIFIHAPEYPLDYHKTPFFNLS 901

  Fly   153 IVVVDRDEGI----------------------------------NSEV--QMKCLEENDICDIFE 181
            |.|.|..:.|                                  |||:  ::..:|..:..|..:
Worm   902 IEVADHGDPILSTSCHLHVELVDIAHNHLAIEFDDVAKEASVYENSEIGTEVIMIEAKETGDEQK 966

  Fly   182 VRA----VKISDGNYTARVALKQQ--------LDFESRPSYILTISASDSAL----DNRLSSLAT 230
            |:|    .:|..|:.....::.|:        ||.|::.:|.:|:.|.||..    |.|...:..
Worm   967 VKAENLEYRIIGGDGWPHFSIDQKGTVRTTHLLDRETKSAYWITVEARDSKTDLYKDPRRRDVLH 1031

  Fly   231 ISINVIDIQDQPPIFTNAPYSATVPENTPAGVSILTVKA-----VDGDVGIPREIFLSLEDEPFG 290
            :.|.::|..|..|:.....|.|:|.||:||.|.|:.|:|     ||.|...|  :...:|.
Worm  1032 VFIRILDRNDHRPVAKKPMYIASVAENSPANVVIVKVEATDADDVDNDAAAP--LMFKIER---- 1090

  Fly   291 HFELVPFGDPR-----DGTAVLQTTS--EPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSL 348
                   |||:     |.|:...|||  ..||||..   ....::|      .:.||..|...|.
Worm  1091 -------GDPQSFFRIDLTSGYITTSGIRRLDREKQ---SEHELWV------SICDGGEPQLCSN 1139

  Fly   349 TRVTIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIFVDDRDMGENSR------------ 401
            ..|.:.|.|.:|:.|||:....:.|:....|..:    ..||..|.|.|||:|
Worm  1140 VIVIVNVLDENDNSPTFTQAIHHYSVRSKFAGKL----CRIFAVDADEGENARLTYNITEGDARF 1200

  Fly   402 -------------------YELSLR--------DVFNAARVF-------------EVSPTESQGR 426
                               |.|:::        ..|.|.||.             :.||.|..|:
Worm  1201 SIDNNGNIIASEAIHGDESYALTVQATDHGTPGQQFAATRVVLTANSAGQKPRKSKNSPPEISGK 1265

  Fly   427 -----TPV--------VVKVLNASRLDYDVV-------DPDLRKFEFD---------LVASVKGV 462
                 .|:        .|..|.||..|.|.:       |||   ..||         |...|:.:
Worm  1266 KSDYVIPISDADQVGLTVGKLEASDADGDELWWSISSGDPD---SVFDVRQDTGQLLLAKKVELL 1327

  Fly   463 EKAKTRVEIHLLDAN---------------DNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDS 512
            ::.:.|:.|.:.|..               ...|.|....|:...:|.:.|...|..:||    |
Worm  1328 KRGELRLNISVTDGQAWDHSTVIIQVSRQISQRPKFSASHYQTDVSERVAVGTQIYTLKA----S 1388

  Fly   513 GE-FGHVRYVLKGFGADN------FYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGGQREANAN 570
            || .|....|...|..|:      ..|.|.:|.|.:::|||||...... .||.:.....::.|.
Worm  1389 GESLGTKPLVFNLFSVDDVAMEDKIRVEPSSGNVIVMEPLDYEAARRIR-AVVQVQQANMKSFAT 1452

  Fly   571 LFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAHDADGPSQG-NGRVKYSIVSENSIAG 634
            ..|.:.|.|||.|.|........:.|...:.:....|.|.|.|   :| ||.|.|||||.|.  .
Worm  1453 FSVNINDENDNSPYFVGHTAFAFVDESDTVDDVLATVTAFDKD---RGENGIVTYSIVSGNE--E 1512

  Fly   635 NVFRIEPDTGEI--------------------VIQKAARSMDTERG------------------- 660
            ::|:|:..:||:                    .|..||.|:..|..
Worm  1513 SLFKIDAKSGEVRLAKPLDPELQHVESILRIRAIDSAANSLKDEMSLHIRNSNEAPETAKFDRKV 1577

  Fly   661 --------------------------EYELVVSATDFGIPPLS---------------------- 677
                                      .|:|..:.|.|.:..||
Worm  1578 YQTTLYDSTRPGTPVLVLNALHHGTVSYKLEPNCTFFEVHTLSGAVHLATWLTKLKHRKSVECTA 1642

  Fly   678 ---------NTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSNVTS--- 730
                     :..:|:.::..:....||||...             ||.:|.||...||:|.|
Worm  1643 IVESTEGQQDIAKVIAKIIRTNQHSPIFRRQV-------------YRGTIRENMPTGSSVLSKSL 1694

  Fly   731 ----VSAHDPD-GLDSLLRYRIVGANDN--FEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVD 788
                |||.|.| |.:.|:.||::...|.  |.:|:.||.|..  |...|.: .|..:...|.|.|
Worm  1695 LPLVVSAIDEDPGSNGLVGYRMLSPKDEQMFSVDQYSGAIRT--QMSFDFE-KMKEYSFYVQAFD 1756

  Fly   789 SGTPIPETA--TTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKDLNSKLEY- 850
            .|.| |..:  .:.:.|.|.|.|||.|:|..||....:...||.|.||....|.|.|....|.|
Worm  1757 MGQP-PRRSLMPSLIVVTVIDENDEPPRFPSNSLDISMILPTANGVSVGGQTAQDMDSVGSLRYF 1820

  Fly   851 -----------SMVGPVAATTKAGVSIA-----------------------------------NR 869
                       |..|.|......|:|..                                   .|
Worm  1821 IKDQSVPFSVDSKTGDVLVKDSNGISDMTKLFDLEVFVTDGKQSASYVMKISTISTENSKFKFTR 1885

  Fly   870 SNYRL--------------------------------QEAFRVDSQSGEIFVNG-TLRHDVAAII 901
            :.|..                                .|||.:...:|.|..:| .|..:.:|||
Worm  1886 NEYHTSLIENTTLPPGSIILSVATIGDKLDHFSIVNPHEAFFIHPGTGVISSSGIALDREKSAII 1950

  Fly   902 ------------------IFTVGVRDLNAE---------------------------VD------ 915
                              :..||:.::|.|                           :|
Worm  1951 RLVVQAKSHEKNPVMARALVVVGIENINDETPIFMGTPYDITIGHSDIGTVVLEPKVIDNDEGDV 2015

  Fly   916 --------PE----------------------------------GQVDTTEVTVYVQSFQDTNPV 938
                    ||                                  |.|...|..|.::......||
Worm  2016 VTISSENMPEYFKIVGGKVVLGKKLPSIEEEDLEFNFKLIAKDNGSVHRVEEPVKIRVVDKARPV 2080

  Fly   939 FKNTGWT-------SSRPVIDVKIKEEMPIDS------ALFILQAEDP----------------- 973
            |....:|       :.:..:.||:..:..:.|      ...||..:.|
Worm  2081 FSQNVYTAVISKESTKKSTVLVKVMAKSSLQSKSKGLIGYRILDKKSPFSVDFLTGEVRLNNLKM 2145

  Fly   974 ---------VTRQPITSFELIEPKQVDY------------------------------------- 992
                     |..:.:|..::|...||:.
Worm  2146 LAETNYTFEVEAREVTRPKMIAKAQVEIIVKSGITTHAPVFEKLKYTASTPESTSIGQRLLTIKA 2210

  Fly   993 ------------------FQVAERTGEVILKKRLDYEALGDTGPEFELQVRANSADRQRSTVSRV 1039
                              .::...||:|.:..:||||..    .:::|::.|.|:.:|.|:.:..
Worm  2211 TTSDENDTIEYSLSGSKDIEIHPETGDVTITGQLDYEKT----QKYDLKLVATSSGKQVSSEAEF 2271

  Fly  1040 NITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQGEH 1104
            .:.:|:|||..|.|.|:...|.|.::....:.:..:.|.|.|.. |:.||.  ..|::|.:....
Worm  2272 IVLIEDVNDEMPEFIRSDVSAKISDSAITGQFITIMSATDMDTT-NSLDEE--SQKLLYKIVDGD 2333

  Fly  1105 AMLFDINNTTGEI--------------------------------------IVASGQ-------- 1123
            ..||:|:..|||:                                      |:.||.
Worm  2334 ETLFNISPATGELSLARPVEQDDLVNEDTKKVLNVSVTDGMFTAYAKLVVEILRSGSMQPPPRFE 2398

  Fly  1124 ----------------------------------------------------TIDRE-------- 1128
                                                                .|||:
Worm  2399 QSHYVANALENTIVNKSALLTVAVKGGVPPLQFSLAPTTSSNSSTSKEAWPVAIDRKTGRIHVSR 2463

  Fly  1129 -----RTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDSF 1188
                 |..|.|:.:..||:.||     ::...|.:.|:|:||..|.|....|||.|.|:|:....
Worm  2464 VLNYHRDKRYQIPLVVEDATGR-----RAFSTLTLSVIDINDKPPFFVLPFYSTSISESAKEGDT 2523

  Fly  1189 VLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDNG 1253
            |:.:.|.|.||  ...:.|.|: :|..:..|.:..:.|.|:..:.|..|... ...|.::|.|:.
Worm  2524 VMMVSATDDDE--NDTIEYSLL-DGSESQFFSVHPRQGTITVAKKLEHKAGV-TLSLTIKATDSA 2584

  Fly  1254 NQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTENAVTGAPVFQVIASDPD-DES 1317
            |     |.....|.|.:.|...|..  ||.|.:..  .:.:|.|:|..|..:.:|...:.: ||
Worm  2585 N-----PPHHATTTVEVNIASESVK--VPRFSNSH--YLFSVMEDADVGNVIGRVQQMETEIDE- 2639

  Fly  1318 TPSGTITYRILPDTPDAEAFV---IDAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRI 1379
                 |.:.|:|.:.::::|:   ::..:|.|..:.|:|||.|:.:::.:.....|......|
Worm  2640 -----IRFTIVPGSEESDSFLPFSVERSTGKIIVKSSLDRERKNQWKMTIRADAAGGVHAITT-- 2697

  Fly  1380 LQIAILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQ 1444
            :.:.|.||:|:.|.|..:.:    ..::.|:...||.|..|||:|.|...:..|.:.:::.|  .
Worm  2698 VTVDIGDVNDNAPAFHGDYE----RFTISEDAAVGTSVTIFSAMDRDDSPSGRIRFSLVEEN--P 2756

  Fly  1445 LFTIERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVLD 1509
            .|.:   ||:...|.....:|||:::.:.|..:.  ..|.|:.           :.|...:.|.|
Worm  2757 YFDL---NENSGWLTVASQLDREKIDHYKLIARA--TDEGGFN-----------TDLPFTIVVSD 2805

  Fly  1510 IDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADAEAPPVGLSIENVT--FVPQFYKRSRSLA 1572
            ::|:.|:||:.:  ..|.:::|..:.:......|.|       ||..||:  |:|:
Worm  2806 VNDSPPQFEKEE--FNIDLHLPSTSPILHFSIKDDD-------LSPNNVSQFFIPK--------- 2852

  Fly  1573 VGNLHNLFTLNN 1584
             ||...:|.:::
Worm  2853 -GNEEGVFWIDS 2863

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.