DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and Fat1

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:XP_006509330.1 Gene:Fat1 / 14107 MGIID:109168 Length:4645 Species:Mus musculus


Alignment Length:1905 Identity:491/1905 - (25%)
Similarity:794/1905 - (41%) Gaps:412/1905 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 SLSENTPVGSPVFQLKGTDPEGGRLKYSISGP--VFSVDRETGVVRLRQ-ELDRETQDTVEVIIS 96
            :|:..|.:|:|:     .:|    |.|.|..|  .|.:...:||:.... ..|||.|:|.:|::.
Mouse  2022 TLAVITAIGNPL-----NEP----LFYRILNPDRRFKISHTSGVLSTTGIPFDREQQETFDVVVE 2077

  Fly    97 ITDEGIYGTEPNTVSQRRV-IPVRDYNDNQPTFLGRPYTASVSESLPVGSELSVEPPIVVVDRDE 160
            :|.|    .||:.|:...| :.|.|.|||.|.|:..||.|.|.....||..:..   :..:|||.
Mouse  2078 VTKE----HEPSAVAHVVVKVTVEDQNDNAPVFVNLPYYAVVKVDAEVGHVIRY---VTAIDRDS 2135

  Fly   161 GINSEVQMKCLEEND-------------------------------------------------- 175
            |.|.::.....|.:|                                                  
Mouse  2136 GRNGDIHYYLKEHHDHFQIGPSGDISLKKQFEHDTLNKEYLVTVVAKDGGSPAFSAEVLVPITVM 2200

  Fly   176 --ICDIFE--------------------VRA---------VKISDG--------NY-TARVALKQ 200
              ...:||                    ::|         ..|:||        |: |..|.:..
Mouse  2201 NKAMPVFEKAFYSAEIPENIQMHSPVVHIQANSPEGLKVFYSITDGDPFSQFTINFNTGVVNVIA 2265

  Fly   201 QLDFESRPSYILTISASDSALDNRLSSLATISINVI--DIQDQPPIFTNAPYSATVPENTPAGVS 263
            .|||||.|:|.|::.|:||.    ..:.|.:.:::|  ||.|.||:|....||.|:.|.:..|..
Mouse  2266 PLDFESHPAYKLSVRATDSL----TGAHAEVFVDIIVEDINDNPPVFVQPSYSTTLSEASVIGTP 2326

  Fly   264 ILTVKAVDGDVGIPREIFLSL---EDEPFGHFELVPFGDPRDGTAVLQTTSEPLDRENAEILQNG 325
            :|.|:|.|.|....|.|...|   ..:...||.:       |....|.:....||.|.:   |..
Mouse  2327 VLQVRATDSDSEPNRGISYQLIGNHSKSHDHFHI-------DSNTGLISLVRALDYEQS---QQH 2381

  Fly   326 GVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIF 390
            .::|   ||   :||.:||..|...||:.|||::|:.|.|....:...|:|:.|:|..:  :.:.
Mouse  2382 RIFV---RA---VDGGMPALSSDVVVTVAVTDLNDNPPLFEQQVYEARISEHAAHGHFV--MCVR 2438

  Fly   391 VDDRDMGENSRYELSLRDVFNAARVFEVSPTESQGRTPVVVKVLNASRLDYDVVDPDLRKFEFDL 455
            ..|.|..:..:.|.|:.. .|..:.|.:.      |...::.:.|..|       ..|:.| :.|
Mouse  2439 ACDADSSDLDKLEYSILS-GNDHKSFIID------RETGIITLSNLRR-------HTLKPF-YSL 2488

  Fly   456 VASVK-GVEKAKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVR 519
            ..||. ||.::..||.:.::..|.::|||.|..|....|||.|:..::..|||:|.|||.:.||.
Mouse  2489 NVSVSDGVFRSSARVNVTVMGGNLHSPVFHQNEYEVELAENAPLHTLVVQVKASDRDSGIYSHVT 2553

  Fly   520 Y-VLKGFGADNFYVNPETGGVYLLKPLDYE--KQSSYSLTVVAIDGGQREANANLFVGVTDVNDN 581
            | ::..|..|.|||| :.|.::.|:.||.|  .:...|:.::|.|.|.:.|...:.|.:||.|||
Mouse  2554 YHIVNDFAKDRFYVN-DRGQIFTLEKLDRETPAEKVISIRLMAKDAGGKVAFCTVNVILTDDNDN 2617

  Fly   582 HPNFESKEYSRTIREGAALFEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEI 646
            .|.|.|.:|...|...||.......|.|.|||..|  |..|.|:|.:::........|...||.|
Mouse  2618 APQFRSTKYEVNIGSSAAKGTSVVKVFASDADEGS--NADVTYAIEADSESVKENLEINKLTGLI 2680

  Fly   647 VIQKAARSMDTERGEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGP 711
            ..:::...::.|  .:...|.|.|.|.||..:...|.:::             ......||....
Mouse  2681 TTKESLIGLENE--FFTFFVRAVDSGSPPRESVVPVYIKI-------------LPPEVQLPRFSE 2730

  Fly   712 PSYRVSIPENAAAGSNVTSVSAHDPDGLDSLLRYRIVGAN-------DNFEIDEISGLITVSPQA 769
            |.|..:|.|:...|:.:..:....    ...:.|.:|..|       :.|.||..:|.:.:  :.
Mouse  2731 PFYTYTISEDTPIGTEIDLIRVEH----GGAVLYILVKGNTPESNRDEFFVIDRQNGRLKL--EK 2789

  Fly   770 RIDRDS------------NMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDERPKFEQNSYAT 822
            .:|.::            .::.:|::             |:..|.:.|||.||..|..|.:.|..
Mouse  2790 SLDHETTKWYQFSILARCTLDDYEVV-------------ASIDVSIQVKDANDNSPVLESSPYEA 2841

  Fly   823 YVSERTAVGESVLRVKAIDKD--LNSKLEYSMVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSG 885
            ::.|....|..|::::|.|.|  .|.::.|              |:....:..:.|:|.::.::|
Mouse  2842 FIVENLPGGSRVIQIRASDLDSGANGQVMY--------------SLDQSQDADIIESFAINMETG 2892

  Fly   886 EIFVNGTLRHDVAAIIIFTVGVRDLNAEVDPEGQVDTTEVT-VYVQSFQDTNP-----VFKNTGW 944
            .|.....|.|:..|.....|...|...:|    |:.:|.:. |.|....|:.|     ::|.|  
Mouse  2893 WITTLKELDHEERASYQIKVVASDHGEKV----QLSSTAIVGVTVTDVNDSPPRFTAEIYKGT-- 2951

  Fly   945 TSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQPITSFELIEPKQVDYF------------QVAE 997
                      :.|:.|....:.||...|..|.:        ..:||.||            :..:
Mouse  2952 ----------VSEDDPPGGVIAILSTTDADTEE--------INRQVSYFITGGDALGQFAVENVQ 2998

  Fly   998 RTGEVILKKRLDYEALGDTGPEFELQVRANSADRQRSTVSRVNITVENVNDNSPRFERNSYQATI 1062
            ....|.:||.||.|    ....:.|.|.|  .|...|:.:||.:.|.:.|||||..|:.||..||
Mouse  2999 SDWRVYVKKPLDRE----QKDSYLLTVTA--TDGTFSSKARVEVKVLDANDNSPVCEKTSYSDTI 3057

  Fly  1063 IENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQGEHAMLFDINNTTGEIIVASGQTIDR 1127
            .|:....:.|::|.|.|.|...||        :|.|:|.|..|..|.:|..|||:...:  .:||
Mouse  3058 PEDALPGKLVMQVSATDADIRSNA--------EITYTLFGSGAEKFKLNPDTGELRTLA--LLDR 3112

  Fly  1128 ERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDSFVLQL 1192
            |......|.:||.|..||   :.|:.:.|.:|  ||||||||||.:.|:..:.||.:..:.:.::
Mouse  3113 EEQAVYNLLVKATDGGGR---SCQAAIVLTLE--DVNDNAPEFTAEPYTITVFENTEPGTPLTRV 3172

  Fly  1193 EAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDNGNQMP 1257
            :|.|||.||..::.|.||.  .|:|.|.|:.:||:|...::|..:.:| .|.|.::|.|.|  :|
Mouse  3173 QATDADTGLNRKISYSLVE--SADGQFSINERSGIIQLEKHLDRELQA-VYTLTLKAVDQG--LP 3232

  Fly  1258 KQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTENAVTGAPVFQVIASDPDDESTPSGT 1322
            ::.| :|.|   :.:..:..||..|.|.....|  |:|:|:.|.|..|.||.|:..|.|:  :..
Mouse  3233 RRLT-ATGT---VVVSVLDINDNPPVFEYREYG--ASVSEDIVIGTEVLQVYAASRDIEA--NAE 3289

  Fly  1323 ITYRILPDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDV 1387
            |||.|:......: |.||:.:|.|...:|:|.|:...|.:.:|.:|.|.|..|....:.|.:.|:
Mouse  3290 ITYAIISGNEHGK-FSIDSKTGAIFIIESLDYESSHEYYLTVEATDGGTPSLSDVATVNINVTDI 3353

  Fly  1388 DDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLFTIE--R 1450
            :|:.|.|:::.....:|.....|:|..||:.:    |.|...|:.|.|.||:||....|||:  |
Mouse  3354 NDNSPVFSQDTYTTVVSEDAALEQPVITIMAD----DADGPSNSHIHYSIIEGNQGSPFTIDPVR 3414

  Fly  1451 NNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVLDIDDNLP 1515
            ..     :|..||:|||.:..:|||::....|.|           ..::...:|:.|.|::||.|
Mouse  3415 GE-----VKVTKPLDRETISGYTLTVQAADNGNP-----------PRVNTTTVNIDVSDVNDNAP 3463

  Fly  1516 KFEQPDPTVGIRINVPIDTVVTTLKASDADA--EAPPVGLSIENVTFVPQFYKRSRSLAVGNLHN 1578
            .|.:.:.:|.|:.|.|:...|..|..:|.|:  ..||...:|.:                ||..|
Mouse  3464 LFSRDNYSVIIQENKPVGFSVLKLVVTDKDSSHNGPPFFFTIVS----------------GNDEN 3512

  Fly  1579 LFTLNNRTGELRTGGSFADYVDGYFLMRVMANNSVQPKRQAHSNLKVFVIRDKSLLKFVFARPPN 1643
            .|.:|.. |.|.|..:....|..::|:.|...:|.:|:..:.:::.:.||.:.       ..||.
Mouse  3513 AFEVNQH-GVLLTAATIKRKVKDHYLLHVKVADSGKPQLSSMTHIDIRVIEES-------IHPPA 3569

  Fly  1644 --EIQHNIRPFQEQLQKKLKPLGLELHVLDTQVFTRPDMSLD------FTATSSCFQMFKNGAAL 1700
              .::..|..|.|:....:  :| ::|..|..|:.....|||      |:.:|:      .|..:
Mouse  3570 ILPLEIFITAFGEEYSGGV--IG-KIHATDQDVYDTLMYSLDPHMDGLFSVSST------GGKLI 3625

  Fly  1701 SFNEM---QKLMN-----------------SQQLRQELIDIYAAYGVSEVESCSVRRTHAAAIFA 1745
            :..::   |.|:|                 .||:.||:::                  |..||..
Mouse  3626 AHRKLDIGQYLLNVSVTDGKFTTVADITVHIQQVTQEMLN------------------HTVAIRF 3672

  Fly  1746 GMLTS----AGAWLVFLAAL 1761
            ..||.    ...|..|..||
Mouse  3673 ANLTPEEFVGDYWRNFQRAL 3692

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637 27/92 (29%)
Cadherin_repeat 132..240 CDD:206637 37/199 (19%)
Cadherin_repeat 249..361 CDD:206637 34/114 (30%)
Cadherin_repeat 369..479 CDD:206637 23/110 (21%)
Cadherin_repeat 487..581 CDD:206637 35/96 (36%)
Cadherin_repeat 589..686 CDD:206637 26/96 (27%)
Cadherin_repeat 713..810 CDD:206637 18/115 (16%)
Cadherin_repeat 819..936 CDD:206637 25/119 (21%)
Cadherin_repeat 953..1049 CDD:206637 25/107 (23%)
Cadherin_repeat 1057..1166 CDD:206637 37/108 (34%)
Cadherin_repeat 1175..1279 CDD:206637 30/103 (29%)
Cadherin_repeat 1293..1390 CDD:206637 31/96 (32%)
Cadherin_repeat 1402..1513 CDD:206637 32/112 (29%)
Cadherin_repeat 1523..1628 CDD:206637 24/106 (23%)
Fat1XP_006509330.1 Cadherin_repeat 39..145 CDD:206637
Cadherin_repeat 154..253 CDD:206637
Cadherin 278..357 CDD:421759
Cadherin_repeat 372..460 CDD:206637
Cadherin_repeat 468..566 CDD:206637
Cadherin_repeat 576..663 CDD:206637
Cadherin_repeat 725..819 CDD:206637
Cadherin_repeat 827..924 CDD:206637
Cadherin_repeat 933..1017 CDD:206637
Cadherin_repeat 1044..1136 CDD:206637
Cadherin_repeat 1144..1242 CDD:206637
Cadherin_repeat 1251..1346 CDD:206637
Cadherin_repeat 1364..1477 CDD:206637
Cadherin_repeat 1486..1583 CDD:206637
Cadherin_repeat 1591..1687 CDD:206637
Cadherin_repeat 1696..1786 CDD:206637
Cadherin_repeat 1794..1899 CDD:206637
Cadherin_repeat 1909..1995 CDD:206637
Cadherin_repeat 2009..2102 CDD:206637 27/92 (29%)
Cadherin_repeat 2110..2199 CDD:206637 13/91 (14%)
Cadherin_repeat 2212..2304 CDD:206637 22/95 (23%)
Cadherin_repeat 2312..2395 CDD:206637 27/98 (28%)
Cadherin_repeat 2419..2513 CDD:206637 23/110 (21%)
Cadherin_repeat 2521..2617 CDD:206637 35/96 (36%)
Cadherin_repeat 2626..2719 CDD:206637 26/109 (24%)
Cadherin_repeat 2733..2830 CDD:206637 19/115 (17%)
Cadherin_repeat 2838..2938 CDD:206637 24/117 (21%)
Cadherin_repeat 2947..3044 CDD:206637 27/122 (22%)
Cadherin_repeat 3052..3146 CDD:206637 37/108 (34%)
Cadherin_repeat 3154..3251 CDD:206637 31/105 (30%)
Cadherin_repeat 3259..3356 CDD:206637 32/101 (32%)
Cadherin_repeat 3364..3461 CDD:206637 32/116 (28%)
Cadherin_repeat 3470..3561 CDD:206637 24/107 (22%)
Cadherin_repeat 3586..3659 CDD:206637 14/81 (17%)
LamG 3879..4010 CDD:214598
EGF_CA 4041..4075 CDD:238011
EGF_CA 4078..4113 CDD:238011
EGF 4118..4148 CDD:394967
EGF_CA 4152..4188 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24026
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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