Protein Alignment Cad74A and LOC1281582

DIOPT Version :10

• Sequence 1: NP_648973.1
• Gene: Cad74A / 39936
• FlyBaseID: FBgn0036715
• Length: 1820
• Species: Drosophila melanogaster
• Sequence 2: XP_061500640.1
• Gene: LOC1281582 / 1281582
• VectorBaseID: AGAMI1_012303
• Length: 1886
• Species: Anopheles gambiae
• Alignment Length: 1926
• Identity: 525/1926 - (27%)
• Similarity: 869/1926 - (45%)
• Gaps: 283/1926 - (14%)

  Fly     4 LLLPLFLSLTAGQLV--NQPPQFVPGTGDMSRFSLSE--NTPVGSPVFQLKGTDPEGGRLKYSIS 64
            |:|.|.||.|   ||  |:.|.|:..........|.|  .||||:.:::|:|.|.:|..|.:.:
Mosquito    30 LVLCLILSAT---LVSCNRAPVFLIDDHAEIVIRLREFPETPVGTLIYRLRGYDADGDPLTFGV- 90

  Fly    65 GPVFSVDRETGVVRLRQ------------ELDRETQDTVEVIISITDEGIYGTEPNTVSQRRVIP 117
                ....::.::||:|            |||||.::...:|:::|| |..| |.|.|:|..::.
Mosquito    91 ----QKSADSHIIRLKQNTSSEAFVYLNHELDREAREEYTLILTLTD-GRLG-EGNFVTQSFLLL 149

  Fly   118 VRDYNDNQPTFLGRPYTA--SVSESLPVGSELSVEPPIVVVDRDEGINSEVQ---MKCLEENDIC 177
            |.|.|||:|.|  :|:.:  .|:|..|.|...::|    .||:|||...:|.   ....|||::
Mosquito   150 VEDINDNEPIF--KPFASVLEVAEDSPPGILTTLE----AVDKDEGAYGQVVYYIQGLSEENNV- 207

  Fly   178 DIFEVRAVKISDGNYTARVALKQQLDFESRPSYILTISASDSALDNRLSS-LATISINVIDIQDQ 241
                   ..||..|....|.|.:.||:|.:..|.:.:.|.|.|:..|::: .|.:.:.|.|::||
Mosquito   208 -------FSISTSNGKGVVRLARALDYERQHFYHINVLAVDRAIQGRINTGTAALLVRVKDVEDQ 265

  Fly   242 PPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSLEDEPFGHFELVPFGDPRDGTAV 306
            ||.|........:.|:.|.|..::.|||||||.||...|...:.:.....||:    |...|:.
Mosquito   266 PPEFLVTQPVVRISEDAPIGTEVMRVKAVDGDRGINNRIIYGISNNGSELFEI----DRLKGSL- 325

  Fly   307 LQTTSEPLDRENAEILQNGG--VYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSGPH 369
              .|.:.||||:::...||.  :.|.:|..::|    .||..|...:|::||||:|..|.|....
Mosquito   326 --RTKQKLDREDSKNPINGAFILEVVAIEESKL----QPAPSSTMEITVIVTDVNDEIPRFRSDG 384

  Fly   370 FNVSITENLANGMPLPGLSIFVD-------DRDMGENSRYELSLRDVFNAARVFEVSPTESQGRT 427
            :...|.||.....    |:.|:|       |.|.|:|..:.|||..   .:.:|||.|..:....
Mosquito   385 YECEIGENAQENT----LARFIDGSINEVFDYDQGKNGTFRLSLHP---PSDIFEVIPKRAINEA 442

  Fly   428 PVVVKVLNASRLDYDVVDPDLRKFEFDLVAS-VKGVEKAKT-RVEIHLLDANDNAPVFDQGTYRF 490
            ...::|.:.|.|||:.|    |:....:||| |:...:..| ::.:.:||.|||.|.|.|..|..
Mosquito   443 TFGLRVKDPSMLDYERV----RELSLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPVYEI 503

  Fly   491 TAAENLPVDAIIGHVKATDLDSGEFG--HVRYV-LKGFGADNFYVNPETGGVYLL---KPL-DYE 548
            ...||:....::..::|||.|||.||  .|||. |.|..:...:::|..|.|.|:   .|: |.|
Mosquito   504 DVPENVTAGTVLVQLQATDSDSGLFGTEGVRYTNLTGSISSFLHLDPHAGTVTLMASESPVFDRE 568

  Fly   549 KQSSYSLTVVAIDGGQREANAN---LFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAH 610
            ....:.|:|.|.|.|.| .|.|   |.:.|.|||||.|.|..|.|...::|.|..||....|.|.
Mosquito   569 IIQKHYLSVEARDNGGR-GNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEAR 632

  Fly   611 DADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTERGE----------YELV 665
            |:|.....|..|:|.::..:.  .:.|.::..||.:.:::|   :|.||.|          ..|.
Mosquito   633 DSDLEGSPNSAVEYRLIGAHH--SDYFHVDRRTGRLSVREA---VDFERLESSGGSGDTRTIALT 692

  Fly   666 VSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSNVTS 730
            :.|.|.|.|||:....|.|.|....:..|:|      :|:       .|.:.|||:..:|..|..
Mosquito   693 IEAADGGEPPLTAQVEVTVYVQDVNDYAPVF------LES-------QYAIVIPEDTPSGLPVLR 744

  Fly   731 VSAHDPDGL--DSLLRYRI-VGANDNFEIDEISGLITVSPQARIDRD-------SNMNSFEIIVN 785
            |:|.|.||.  ::.:.||| .|.:..|.|...:|.|:::..|.:|.:       .:.:::.:.|.
Mosquito   745 VTAMDGDGSFPNNHVTYRIQQGGDGRFVIGASTGEISITHGASLDPNLLAPDALGSGSTYVLEVF 809

  Fly   786 AVDSGTPIPE-TATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKDLNSKLE 849
            |.|.|....: ..:..|.|.:.|:|::.|.| ....|..|.|.|.||..|.|:.|.|.|..:.|.
Mosquito   810 ATDGGNGDQQLQGSCLVNVTITDVNNKPPYF-VGPTAVAVRENTPVGTEVYRLMATDPDEGAMLR 873

  Fly   850 YSMVGPVA-ATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDLNAE 913
            |.:...:: ..|:.| ::....:|....||.::..:|.:.:...|..:..|.|.....|.|:.||
Mosquito   874 YYIDRSLSEGKTEEG-ALVKLDDYDFAAAFILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAE 937

  Fly   914 VDPEG-QVDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQ 977
               .| |:..|.:.:.|....|.||.|:       :|.....|.|......|:..:.||| ..:.
Mosquito   938 ---RGDQMANTFLKITVLDENDNNPKFR-------KPFYKHSIAENSQYGVAVCTVVAED-ADQN 991

  Fly   978 PITSFELIEPKQV-DYFQVAERTGEVILKKRLDYEALGDTGPEF---ELQVR-ANSADRQRSTVS 1037
            ....:.|...|.| :...|.:.|||::::.|:|:|       |:   ...|| |::....|::..
Mosquito   992 KTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHE-------EYSWLNFSVRAADTGTPPRASFV 1049

  Fly  1038 RVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLG-YHKIIYSLQ 1101
            .|.:.|.:.|||:|.|..:.....:.||......:         |::.|:|...| :.:|.|.|.
Mosquito  1050 EVFVQVLDENDNNPYFVDSVNDYYVSENASVGAEI---------AIILAKDLDYGDFGRITYILD 1105

  Fly  1102 GEHAM-LFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDS------PGRPTDAKQSVVELQIE 1159
            ...:. .|.|:...|.:.||.  .:|||.|....|.::|.|:      .|...:|.:.::   |.
Mosquito  1106 RVSSKEKFSIDPEKGILRVAG--ALDREETAEYMLAVEAWDNYPYGYLNGESRNAFKHIL---IH 1165

  Fly  1160 VLDVNDNAPEFTQKKYSTVIPENAQIDSFVLQLEAVDADEGL--GGEVRYELVNEGEANGLFKID 1222
            |||.|||.|...:....::|.|...|:..:::|.|.|||:..  .|::.:::|   :.:|:|.|.
Mosquito  1166 VLDDNDNVPVIQKPSGCSMITEYHNINDPIVKLRATDADDPTNGNGQLSFDIV---DPSGIFYIQ 1227

  Fly  1223 TKSGL---ISTR---RNLTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGV 1281
            ..|..   |.:|   :||.|.     |.|.:...|.|. :|.....|.|..|..:      ||..
Mosquito  1228 QVSAQYAEIYSRGPLKNLHGN-----YTLELIVSDLGG-VPNTARESVDICVTDF------NDHA 1280

  Fly  1282 PYFLSPRVGQMANVTENAVTGAPVFQVIASDPDDESTPSGTITYRILPDT-PDAEAFVIDAHSGL 1345
            |.|:.|.......|.||...|.|.|||.|.|.|  ...:..:.||:..|| .:...|.:|..:|.
Mosquito  1281 PVFVVPSGNTTVKVFENTTLGKPFFQVHAYDED--VGENAIVRYRLKMDTMGNFRKFSLDMETGE 1343

  Fly  1346 ITTRQSMDRETKDMYRILLEVSDNGQPKQ-SATRILQIAILDVDDHEPRFAREADAGPLSMSVRE 1409
            ::....:|||.:.||.:.:|..|.|.|.. |:|..|.:.:.||:|:.|:|..:    .:|::..|
Mosquito  1344 LSLAAPLDREQQMMYDLRIEAYDQGIPTPLSSTVDLIVYVRDVNDNLPQFLLK----EISLNFTE 1404

  Fly  1410 EEPAGT-IVGNFSALDEDL-----GENAA-IDYVIIDGNNEQLFTIERNNESLAILKTKKPIDRE 1467
            ....|| .:.....:|:|.     |..|: :.|.|:.||.:..|.::.....|.:   :|.:|||
Mosquito  1405 HTTPGTERIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVTHDLTV---EKELDRE 1466

  Fly  1468 QVESFTLTIKC--------LKLGEPGYKFIGDPYDRQDLSHLRINVRVLDIDDNLPKFEQPDPTV 1524
            :...:.|.||.        |.|...|:..          :.|:..|.:.||:||.|.||....|.
Mosquito  1467 KKSLYKLHIKATEECTNANLSLDTTGHSG----------NILKATVYINDINDNSPLFESKIFTG 1521

  Fly  1525 GIRINVPIDTVVTTLKASDADAEAPPVGLSIENVTFVPQFYKRS---RSLAVGNLHNL----FTL 1582
            ||..:......:..|:|:|.|          :.:..:.::|:..   ::||.| |.:|    |.:
Mosquito  1522 GISTSSLFGATILQLQATDED----------DGLNGLVRYYRHGEVRKTLAEG-LDDLRSDPFLV 1575

  Fly  1583 NNRTGELRTGGSFADYVDGYFLMRVMANNSVQPKRQAHSNLKVFVIRDKSLLKFVFARPPNEIQH 1647
            ...||::.........:.|||...|:||:|.....:||  :.:::||:...:||:..:.|:||:|
Mosquito  1576 EADTGKVLLNFFPQKSMRGYFDFSVLANDSYGCHDRAH--VFIYLIREDQRVKFILRQRPSEIRH 1638

  Fly  1648 NIRPFQEQLQKKLKPLGLELHVLDTQVFTRPDMSLDFTATSSCFQMF--KNGAALSFNEMQKLMN 1710
            ||:.|:|.|.   ...|..:::.|.:|...||.|:|.|.:.....:.  ||.:.|..:::.:|::
Mosquito  1639 NIQSFREILS---NVSGCIVNIDDIRVHENPDGSVDRTKSDMFMHLVDQKNNSVLEVHQVLQLLD 1700

  Fly  1711 SQQLRQELIDIYAAYGVSEVESCSVRRTHAAAIFAGM--LTSAGAWLVFLAALIGLAALVSLCTA 1773
            :..  ::|..::..:.|.:.::..:.:|      |.|  |:....||.....|:|  ||:.:...
Mosquito  1701 THV--EKLDRLFKEFNVLDTQASELVQT------AEMDELSVNIIWLFVTNILLG--ALLIVVIG 1755

  Fly  1774 CCLKKKLKRHSKRSLQASLRTPTEHTATSYSYSMPAVLYSE 1814
            ..:.::|.  .:|.|:|:       ...::..:.|:.:|.|
Mosquito  1756 LSISQRLS--YRRQLRAA-------KIAAFGSTGPSRMYQE 1787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad74A	NP_648973.1	Cadherin_repeat	33..124	CDD:206637	31/104 (30%)
		Cadherin_repeat	132..240	CDD:206637	31/113 (27%)
		Cadherin_repeat	249..361	CDD:206637	35/113 (31%)
		Cadherin_repeat	487..581	CDD:206637	36/103 (35%)
		Cadherin_repeat	589..686	CDD:206637	29/106 (27%)
		Cadherin_repeat	713..810	CDD:206637	28/107 (26%)
		Cadherin_repeat	819..936	CDD:206637	31/118 (26%)
		Cadherin_repeat	953..1049	CDD:206637	24/100 (24%)
		Cadherin_repeat	1057..1166	CDD:206637	28/116 (24%)
		Cadherin_repeat	1175..1279	CDD:206637	27/111 (24%)
		Cadherin_repeat	1293..1390	CDD:206637	32/98 (33%)
		Cadherin_repeat	1402..1513	CDD:206637	28/125 (22%)
		Cadherin_repeat	1523..1628	CDD:206637	25/111 (23%)
LOC1281582	XP_061500640.1	None