Protein Alignment Cad74A and LOC1279108

DIOPT Version :10

• Sequence 1: NP_648973.1
• Gene: Cad74A / 39936
• FlyBaseID: FBgn0036715
• Length: 1820
• Species: Drosophila melanogaster
• Sequence 2: XP_061509473.1
• Gene: LOC1279108 / 1279108
• VectorBaseID: AGAMI1_000307
• Length: 2873
• Species: Anopheles gambiae
• Alignment Length: 1759
• Identity: 366/1759 - (20%)
• Similarity: 612/1759 - (34%)
• Gaps: 565/1759 - (32%)

  Fly   287 EPFGHFELVPFGDPRDGTAVLQTTSEPLDRENAEILQNGGVYV-------FSI-----RATELID 339
            :|..|:   |..||           ||.|..:.|..|.....|       |.|     |...:|.
Mosquito   716 QPSSHW---PSSDP-----------EPSDEADLETRQVSAALVCTPTHPWFGISSSFTRMVRIIA 766

  Fly   340 GAI--------------PAEHSLTRVTIVVTDVD---------DHQPTFSGPHFNVSITENLANG 381
            ..|              |..|:....||....||         ..|..||.....:...|.|...
Mosquito   767 YCIRFVRNTKQKARSQRPIPHTNASKTITPKYVDAAKTVLCRLAQQDAFSAEIKQLKKGETLMKQ 831

  Fly   382 MPLPGLSIFVDDRDMGENSRYELSLRDVFNAARVFEVSPTESQGRTPVVVKV---LNASRLDYDV 443
            .||..|:.|:|                                  |..|::|   ||.|:|.|..
Mosquito   832 SPLRKLTPFLD----------------------------------TEEVIRVGGRLNLSQLPYQS 862

  Fly   444 VDPDL--RKFEFDLVASVKGVEKAK--------TRV-EIHL-LDANDNAPVFDQGTYRFTAAENL 496
            ..|.:  :..:|..:.:....|:.|        :|: |::. ||.........:..:|....:..
Mosquito   863 KHPAVLPKNHKFTRLLAEDYHEEMKHASGRLLLSRIRELYWPLDGRRLVKSIARNCFRCVRQDPA 927

  Fly   497 PVDAIIGHVKATDLDSGEFGHVRYVLKGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAID 561
            .....:|.:..:.:.......|.      |.|  |..|     :.|||...:..::.|...|.:.
Mosquito   928 LARQPVGQLPPSRITPSRPFSVT------GVD--YAGP-----FYLKPAHRKAAATKSYLCVFVC 979

  Fly   562 GGQREANANLFVGVTDV--------------------NDNHPNFESKEYSRTIREGAALFEPQFF 606
            ...:..:..|...:|..                    :||..|||..|  |.::|...||..:..
Mosquito   980 FATKAVHLELVGDLTTAGFLAALRRFTSRRGLPAHIHSDNGKNFEGAE--RELKELFELFNDEQH 1042

  Fly   607 ---VRAHDAD-------GPSQ-----------------------GNGRVKY----SIVSE----- 629
               |....||       .|.:                       ||.|:.|    :::.:
Mosquito  1043 RNTVATRCADRGITWHFNPPKAPHFGGLWEAAVKTAKRHLYRHLGNTRLSYEGYCTVLHQIEAAM 1107

  Fly   630 NS----------------------IAGNVFRI-EPDTGEIVIQKAARSMDTERGE--YELVVSAT 669
            ||                      |..::|.: |||..::   |:....|.::.:  .:|::...
Mosquito  1108 NSRPLLPLSDDPNELAALTPAHFLIGTSMFAVPEPDYTQL---KSCTLDDLQKWQLLVQLILQLI 1169

  Fly   670 DFGIPP------LSNTTRVL---VRVGISG-NQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAA 724
            ...:.|      |:|:|.::   ::.|::. |..|:|   |:.:         .|.|.|.||...
Mosquito  1170 GIIVDPLQIFWVLTNSTYLVTKFIKTGVADKNDYPLF---FEKV---------IYEVDIDENVEI 1222

  Fly   725 GSNVTSVSAHDPDGLDSLLRYRIVGAN--DNFEIDEISGLITVSPQARIDRDSNMNSFEIIVNAV 787
            ..|..:||. ...|..|.:||:|...|  :.|.|...:|.:.|:.....::   :..:|:.:.|:
Mosquito  1223 NHNFLNVST-KTHGEVSGVRYKISSGNIGNVFAIHNTTGALYVAKALDYEK---IKKYELRLTAL 1283

  Fly   788 DSGTPIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVG--ESVLRVKAIDKDLN--SKL 848
            |:.    :...|||.:||:|:||..|.||::||.|.::|....|  :.||||.|.|.|:.  :.:
Mosquito  1284 DNF----KENYTTVLINVRDVNDNPPVFEKSSYRTQITEEDDRGLPKRVLRVTASDADVERPNNI 1344

  Fly   849 EYSMVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDLNAE 913
            .|.:.||       |:.|.|.||    ..|.::..:|||||...|..|
Mosquito  1345 IYFLTGP-------GIDIENPSN----SNFDINKATGEIFVLKPLNRD----------------- 1381

  Fly   914 VDPEGQVDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQP 978
             .|.|:. :.:.||:.|
Mosquito  1382 -PPHGRA-SWKFTVFAQ------------------------------------------------ 1396

  Fly   979 ITSFELIEPKQVDYFQVAERTGEVILKKRLDYEALGDTGPEFELQVRANSADRQRSTVSRVNITV 1043
                              :..||            |..|                  .:.|.|.:
Mosquito  1397 ------------------DEGGE------------GLVG------------------FTEVQINL 1413

  Fly  1044 ENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAV---LNARDERLGYHKIIYSLQGEHA 1105
            ::||||:|:|........:.||......|:.::|.|.|.:   .||        |||||::....
Mosquito  1414 KDVNDNAPQFTNGIAYGNVTENGTIGMHVMTIKAEDYDDINEGTNA--------KIIYSIEKNVI 1470

  Fly  1106 M------LFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVN 1164
            .      :||||..|| :|......:|||:||...|||.|.|..|.......|     |:|.|:|
Mosquito  1471 QEDTGLPIFDINPATG-LITTVVCCLDREKTPDYSLQIVATDGGGLKGTGTAS-----IKVKDLN 1529

  Fly  1165 DNAPEFTQKKY--------STVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKI 1221
            |..|.||:.::        .:|:||     :.:|.:...|.||          :|    |..:||
Mosquito  1530 DMPPRFTKDEWLVEVEETDGSVLPE-----APILTVTVNDDDE----------IN----NFQYKI 1575

  Fly  1222 DTKSGLISTR----RNLTGKGRAHPYVLIVRAQD-------NGNQMPKQPTLSTDTD-------- 1267
            ...||..:.:    :|..|.|.    :.:|:..|       ||.:...|...:.|.|
Mosquito  1576 IESSGYGADKFAMVKNADGTGS----LKVVQPLDYEDPMQINGFRFRIQVIDNDDIDESDKYHVD 1636

  Fly  1268 ---VRIYIGDVSANDGVPYFLSPRVGQMANVTENAVTGAPV--FQVIASDPDDESTPSGTITYRI 1327
               |.:.:.|:  ||..|.|..|.:  .|.|.|||..|..:  |:.:..|...:|    .|||.|
Mosquito  1637 HSWVIVKLKDI--NDNTPRFKKPHI--EAAVYENADVGKNLGTFKAVDIDKGGKS----KITYSI 1693

  Fly  1328 LPDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHEP 1392
            ...|.....|.|| ..|::|.::.:|||....:.:.:..:|:|.|.::|..||.:.:.|::|:.|
Mosquito  1694 NRATDRKRQFAID-QEGMVTIQRELDREAMAKHSLEILATDDGVPPRTAFAILTVLVKDINDNAP 1757

  Fly  1393 RFAREADAGPLSMSVREEEPAGTIVGNFSALDED--LGENAAIDYVIIDGNNEQL----FTIERN 1451
            .||.  |..|:.:  ....|:.||  ..||:|:|  |..|.|.....:|.:.:.:    |.:|::
Mosquito  1758 VFAE--DYRPILL--ENSPPSKTI--EISAVDKDDRLEGNGAPFQFRMDPDADDVIRTFFKVEQS 1816

  Fly  1452 N--ESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVLDIDDNL 1514
            |  :.:||:.:....|||..:.:|:.|.....|.|         .:...|.|.|.:.  |::||:
Mosquito  1817 NKGDGMAIISSLGSFDREYRKQYTIPIVIKDSGTP---------PQTGTSTLTITIG--DLNDNI 1870

  Fly  1515 PKFEQPDPTVGIRIN----VPIDTVVTTLKASDADAEAPPVGLSIENVTFVPQFYKRSRSLAVGN 1575
               .||.....|..|    .| ||.:..:..:|.|.......|...:.|..|:
Mosquito  1871 ---MQPGSKEVIVYNYQGQAP-DTPIGRVFVNDLDDWDTSDKLFYWDETENPR------------ 1919

  Fly  1576 LHNLFTLNNRTG--ELRTGGSFADY------VDGYFLMRVMANNSVQPKRQAH------SNLKVF 1626
                |.|::::|  .:|.|.....|      .|........||.|:..|..::      .::::.
Mosquito  1920 ----FKLDDKSGMVSMRRGAREGRYKLRFKIYDRKHAQESYANMSIVVKHISYEAIVNSGSIRLI 1980

  Fly  1627 VIRDKSLLKFVFARPPNEIQHNIRPFQEQLQKKLKPLGLELHVLDTQVFT--RPDMSLDFTATSS 1689
            .:.|:..::....|..|..:..:..|:::|.:.     |.:.|.:..||:  ..|.|:..|..
Mosquito  1981 GVTDEDFIRIWNYRTQNIFRSKLERFRDKLAEL-----LNVDVKNVDVFSVQMKDRSVPLTDV-- 2038

  Fly  1690 CFQMFKNGAALSFNEMQK----LMNSQQLRQELIDIYAAYGVS----EVESCSVRRTHAAAIFAG 1746
               .|....|..:..:|.    |::.:::.||:       |::    .|:.|.:..    |..||
Mosquito  2039 ---RFAVHGAYFYKAVQLNGVILLHKEEIEQEV-------GINITMVNVDECLLEN----ADCAG 2089

  Fly  1747 MLTSAGAWLVFLAALIGLAALVSLCTACCLKKKLKRHSKRSLQASLRTPTEHTATSYSYSMPAVL 1811
            ..||                ::.:.:..||   :..:....:...:.:..|...:|..|......
Mosquito  2090 SCTS----------------IIEVQSNPCL---VNANKTAMVGVQINSTAECVCSSREYKQQQTC 2135

  Fly  1812 YSEP 1815
            .|.|
Mosquito  2136 KSHP 2139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad74A	NP_648973.1	Cadherin_repeat	33..124	CDD:206637
		Cadherin_repeat	132..240	CDD:206637
		Cadherin_repeat	249..361	CDD:206637	22/108 (20%)
		Cadherin_repeat	487..581	CDD:206637	14/113 (12%)
		Cadherin_repeat	589..686	CDD:206637	27/172 (16%)
		Cadherin_repeat	713..810	CDD:206637	27/98 (28%)
		Cadherin_repeat	819..936	CDD:206637	33/120 (28%)
		Cadherin_repeat	953..1049	CDD:206637	8/95 (8%)
		Cadherin_repeat	1057..1166	CDD:206637	36/117 (31%)
		Cadherin_repeat	1175..1279	CDD:206637	25/133 (19%)
		Cadherin_repeat	1293..1390	CDD:206637	29/98 (30%)
		Cadherin_repeat	1402..1513	CDD:206637	28/118 (24%)
		Cadherin_repeat	1523..1628	CDD:206637	21/122 (17%)
LOC1279108	XP_061509473.1	None