Protein Alignment Cad74A and LOC1279098

DIOPT Version :10

• Sequence 1: NP_648973.1
• Gene: Cad74A / 39936
• FlyBaseID: FBgn0036715
• Length: 1820
• Species: Drosophila melanogaster
• Sequence 2: XP_061509423.1
• Gene: LOC1279098 / 1279098
• VectorBaseID: AGAMI1_012222
• Length: 1649
• Species: Anopheles gambiae
• Alignment Length: 1611
• Identity: 333/1611 - (20%)
• Similarity: 544/1611 - (33%)
• Gaps: 529/1611 - (32%)

  Fly    59 LKYSISG----PVFSVDRETGVVRLRQELDRETQDTVEVIISITDEGIYGTEPNTVSQRRVIPVR 119
            ::|.||.    .||::...||.:.:.:.||.|.....|:.::.:|.  :.....||    :|.||
Mosquito    16 VRYKISSGNIDNVFAIRNATGALYVAKALDYEKIKKYELRLTASDN--FQENYTTV----LINVR 74

  Fly   120 DYNDNQPTFLGRPYTASVSE----SLP------VGSELSVEPPIVVVDRDEGINSEVQMKCLEEN 174
            |.|||.|.|....|...::|    .||      ..|:..||.|..::....|...::      ||
Mosquito    75 DLNDNPPVFEKSSYRTQITEEDDRGLPKRVLRVTASDADVERPNNIIYFLTGAGIDI------EN 133

  Fly   175 DICDIFEVRAVKISDGNYTARVALKQQLDFE---SRPSYILTISASDSALDNRLSSLATISINVI 236
            .....|::...       |..:.:.:.|:.:   .|.|:..|:.|.|...:. |.....:.||:.
Mosquito   134 PSDSYFDINKA-------TGEIFVLKPLNRDPPHGRASWKFTVFAQDEGGEG-LVGFTEVQINLK 190

  Fly   237 DIQDQPPIFTNAPYSATVPENTPAGVSILTVKAVDGD---VGIPREIFLSLEDEPFGHFELVPFG 298
            |:.|..|.|.|......|.||...|..::|:||.|.|   .|...:|..|:|.........:|..
Mosquito   191 DVNDNAPQFLNGTAYGNVTENGTIGKHVMTIKAKDYDDINEGTNAKIIYSIEKNAIQEDTGLPIF 255

  Fly   299 DPRDGTAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQP 363
            |....|.::.|....||||...      .|...|.||:  .|.:....:   .:|.|.|::|..|
Mosquito   256 DINPDTGLITTAVCCLDREKTP------DYSLQIVATD--GGGLKGTGT---ASIKVKDLNDMPP 309

  Fly   364 TFSGPHFNVSITENLANGMP-LPGLSIFVDDRDMGENSRYELSLRDVFNAARVFEVSPTESQGRT 427
            .|:...:.|.:.|...:.:| .|.|::.|:|.|...|.:|::.....:.|.:...|...:..|..
Mosquito   310 RFTKDEWFVEVEETDGSVLPEAPILTVTVNDDDEINNFQYKIIESSGYGADKFAMVKNADGTGSL 374

  Fly   428 PVVVKV-------LNASRLDYDVVDPDLRKFEFDLVASVKGVEKAKTRVE-----IHLLDANDNA 480
            .||..:       :|..|....|:|.|    :.|        |..|..|:     :.|.|.|||.
Mosquito   375 KVVQPLDYEDPLQINGFRFRIQVIDND----DID--------ESDKYHVDHSWVIVKLKDINDNT 427

  Fly   481 PVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRYVL-------KGFGADNFYVNPETGG 538
            |.|.:........||..|...:|..||.|:|.|....:.|.:       :.|..|      :.|.
Mosquito   428 PRFKKPHIEAAVYENADVGKKLGTFKAVDIDKGGKSKITYSINRATDRKRQFAID------QEGT 486

  Fly   539 VYLLKPLDYEKQSSYSLTVVAIDGG--QREANANLFVGVTDVNDNHPNFESKEYSRTIREG---A 598
            |.:.:.||.|..:.:||.::|.|.|  .|.|.|.|.|.|.|:|||.|.| :::|...:.|.   :
Mosquito   487 VTIHRELDREAMAKHSLEILATDDGVPPRTAFAILTVLVKDINDNAPVF-AEDYRPILLENSPPS 550

  Fly   599 ALFEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEIV---------------- 647
            .:.|    :.|.|.|...:|||            |...||::||..:::
Mosquito   551 KIIE----ISAVDKDDRLEGNG------------APFQFRMDPDADDVIRTSFKVEQSNKGDGMA 599

  Fly   648 IQKAARSMDTE-RGEYELVVSATDFGIPPLSNTTRVLVRVG-ISGNQRPIFRGHFQNMENLPIIG 710
            |..:..|.|.| |.:|.:.:...|.|.||.:.|:.:.:.:| ::.|                |:.
Mosquito   600 IISSLGSFDREYRKQYTIPIVIKDSGTPPQTGTSTLTITIGDLNDN----------------IMQ 648

  Fly   711 PPSYRVSI--PENAAAGSNVTSVSAHDPDGLDS--LLRYRIVGANDNFEIDEISGLITVSPQARI 771
            |.|..|.:  .:..|..:.:..|..:|.|..|:  .|.|.....|..|::|:.||::|:...||.
Mosquito   649 PGSKEVIVYNYQGQAPDTPIGRVFVNDLDDWDTSDKLFYWDEAENPRFKLDDTSGMVTMRRGARE 713

  Fly   772 DRDSNMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDERPKFEQNSYAT------YVSERTAV 830
            .|      :::.....|.                        |..|.|||.      ::|....|
Mosquito   714 GR------YKLRFKIYDR------------------------KHAQESYANMSVVVKHISYEAIV 748

  Fly   831 GESVLRVKAI-DKDLNSKLEYSMVGPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLR 894
            ....:|:..| |:|.                   :.|   .|||.|..||...:.....:...|.
Mosquito   749 NSGSIRLTGITDEDF-------------------IRI---WNYRTQNIFRSKLERFRDKLAELLN 791

  Fly   895 HDVAAIIIFTVGVRDLNAEVDPEGQVDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEM 959
            ..|..:.:|:|.::|                                    .|.|:|||:    .
Mosquito   792 VHVKNVDVFSVQLKD------------------------------------RSVPLIDVR----F 816

  Fly   960 PIDSALFILQAEDPVTRQPITSFELIEPKQVDYFQVAERTGEVILKKRLDYEALGDTGPEFELQV 1024
            .:..|.|                          ::..:..|.::|.|.           |.|.:|
Mosquito   817 AVHGAYF--------------------------YKAVQLNGLILLHKE-----------EIEQEV 844

  Fly  1025 RANSADRQRSTVSRVNITVENVNDNSPRFERNSYQATIIENRP---HPERVIRVRALDKDAVLNA 1086
                         .:|||:.||::            .::||..   ....:|.|::  ...::||
Mosquito   845 -------------GINITMVNVDE------------CLLENADCAGSCTSIIEVQS--NPCLVNA 882

  Fly  1087 RDERLGYHKIIYSLQGEHAMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAED--SPGRPTDA 1149
            ....|...:|               |:|.|.:.:|       |..:.|...|:..  :.||.||:
Mosquito   883 NKTALVGVQI---------------NSTAECVCSS-------REYKQQQTCKSHPCLNGGRCTDS 925

  Fly  1150 K----------------QSVV--------------------ELQIEVLDVND------NAPEFTQ 1172
            |                |.||                    .:.:|::....      |.|....
Mosquito   926 KSGIKCSCLPGYTGPRCQQVVRSFRGSGWAWYPPLDMCDKSHISVEIITTKPDGLIFYNGPITPP 990

  Fly  1173 KKYSTVIPENAQIDSFV-LQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTG 1236
            |:..|    :.|:..|: |:||.        |..|: |::.|......:|.||..|        .
Mosquito   991 KEDDT----SKQLSDFIALELEQ--------GYPRF-LIDYGSGTLELRIATKHPL--------N 1034

  Fly  1237 KGRAHPYVLI-----------------VRAQDNGN----------QMPKQPTLS--TDTDVRIYI 1272
            .|..|...|.                 :...|:||          .:.|.|..:  .:.:..:.|
Mosquito  1035 DGEWHRIDLFWDTDQVKIVVDFCKTAEITEPDDGNLVEIIDHTCQALGKVPQFNEYLNLNTPLQI 1099

  Fly  1273 GDV---------------------------SANDGVPYFLS-PRVG------------------Q 1291
            |.|                           ..::|:.|.|| |.:.                  |
Mosquito  1100 GGVFRDKFDYTYSRWQYMPVGVGFEGCIREFKHNGILYDLSHPGLSKGSAPGCLYTQEVCDLNPQ 1164

  Fly  1292 MANVTENAVTGAPVFQVIASDPDDESTPSGTITYRILPDTPDA------EAFVIDAHSGLITTRQ 1350
            :|...|:   |..|...:  :...|..|..|.||..||.||..      ..:.:.......||:.
Mosquito  1165 VARCLEH---GKSVGSYV--EAKCECNPGWTGTYCSLPTTPTTFKTHSYVKYALSFEPNKFTTQI 1224

  Fly  1351 SMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHEP--RFAREADAGPLSMSVREEEPA 1413
            .:...|::.|..|..:||.        .:.:..|:::.|.:.  |::...|      .|.|:|.|
Mosquito  1225 QLRFRTRETYGELFRISDQ--------HMREYGIIELKDAKVYFRYSLNTD------QVEEQEVA 1275

  Fly  1414 GTIV---------------GNFSALDEDLGENAAIDYVIIDGNNEQLFTIE 1449
            .|.|               |:.:.|:.|.||.|         |..|.|:.:
Mosquito  1276 LTAVEVDDGQWHVVKVQRYGSAAILELDGGEGA---------NFNQSFSFD 1317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad74A	NP_648973.1	Cadherin_repeat	33..124	CDD:206637	19/68 (28%)
		Cadherin_repeat	132..240	CDD:206637	23/120 (19%)
		Cadherin_repeat	249..361	CDD:206637	29/114 (25%)
		Cadherin_repeat	487..581	CDD:206637	30/102 (29%)
		Cadherin_repeat	589..686	CDD:206637	25/116 (22%)
		Cadherin_repeat	713..810	CDD:206637	19/100 (19%)
		Cadherin_repeat	819..936	CDD:206637	21/123 (17%)
		Cadherin_repeat	953..1049	CDD:206637	14/95 (15%)
		Cadherin_repeat	1057..1166	CDD:206637	24/155 (15%)
		Cadherin_repeat	1175..1279	CDD:206637	25/160 (16%)
		Cadherin_repeat	1293..1390	CDD:206637	21/102 (21%)
		Cadherin_repeat	1402..1513	CDD:206637	15/63 (24%)
		Cadherin_repeat	1523..1628	CDD:206637
LOC1279098	XP_061509423.1	None