Protein Alignment Cad74A and ds

DIOPT Version :10

• Sequence 1: NP_648973.1
• Gene: Cad74A / 39936
• FlyBaseID: FBgn0036715
• Length: 1820
• Species: Drosophila melanogaster
• Sequence 2: XP_061514261.1
• Gene: ds / 1278050
• VectorBaseID: AGAMI1_006399
• Length: 3489
• Species: Anopheles gambiae
• Alignment Length: 2042
• Identity: 520/2042 - (25%)
• Similarity: 841/2042 - (41%)
• Gaps: 505/2042 - (24%)

  Fly     3 PLLLPLFLSLTAGQLVNQPPQFVPGTGDMSRF--SLSENTPVGSPVFQLKGTDP---EGGRLKYS 62
            ||...:.:::|...:.:..|.|     :.||:  ::.||..:|:.|.|:..||.   |.|:::|:
Mosquito   243 PLRGQMTVNITIQDVNDNQPIF-----NQSRYFATVPENATLGTTVLQVYATDQDAGENGQVEYA 302

  Fly    63 IS------GPVFSVDRETGVVRLRQELDRETQDTVEVIISITDEGIYGTEPNT-VSQRRVIPVRD 120
            |:      ..:|.:|..||::.:.:.||.||::..|:::...|.|:...|... ||    |.|.|
Mosquito   303 INRRQSDKEQMFRIDPATGLISVNKPLDFETRELHELVVVAKDRGMQPLETTAFVS----IRVTD 363

  Fly   121 YNDNQP----TFLGRPYTASVSE------------------------------------------ 139
            .|||||    .||....|..:||
Mosquito   364 VNDNQPIINVIFLSDDATPKISESAQPGEFVARISVNDPDSRTEYANVNVTLSGGEGHFGLTTRD 428

  Fly   140 --------SLPVGSE------LSV------EPP-------------------------------- 152
                    |||:..|      |||      .||
Mosquito   429 NIIYLVIVSLPLDREIKPNYTLSVIATDTGNPPLHAAKDIFLTVTDINDNAPEFEKDVYHANVME 493

  Fly   153 ----------IVVVDRDEGINSEVQMKCLEENDI-CDIFEVRAVKISDGNYTARVALKQQLDFES 206
                      :..||||||.||.:....|:..|. ...|::       .:::..:..:..:|.|:
Mosquito   494 VADPGTSVIQVTAVDRDEGNNSAIVYSLLDTPDTHSHWFQI-------DSHSGLITTRAHIDCET 551

  Fly   207 RPSYILTISASDSALDNRLSSLATISINVIDIQDQPPIFTNAPYSATVPENTPAGVSILTVKAVD 271
            .|...|.:.|.|:... .|||..|:.:.:.|:.|..|||..:.|:.:|.||...|..||.|.|.|
Mosquito   552 DPVPQLIVMAQDNGRP-PLSSTGTVLVTIHDVNDNEPIFDQSFYNVSVAENESKGRCILKVSATD 615

  Fly   272 GDVGIPREIFLSLED--EPFGHFELVPFGDPRDGTAVLQTTSEPLDRENAEILQNGGVYVFSIRA 334
            .|.|:...:..:|.:  :....||:      |..|..:...|| ||.|.    :|.  |.|.|.|
Mosquito   616 PDCGVNAMVNYTLGEGYKKNAEFEI------RPSTGEVCIASE-LDYET----RNS--YEFPIIA 667

  Fly   335 TELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSGPHFNVSITENLANG--MPLPGLSIFVDDRDMG 397
            |:  .|.:   .:...|.|.:|||:|::|||....:|||:.|::...  :..|.:.:...|.|.|
Mosquito   668 TD--RGGL---STTAMVKIQLTDVNDNRPTFYPREYNVSLRESMPTNSLLSTPVVVVVATDSDSG 727

  Fly   398 ENSRYELSLR-------DVFNAAR----VFEVSPTESQGRT----------------------PV 429
              |...:|.|       .:|...|    :|...|.....||                      .|
Mosquito   728 --SFGTISYRIVAGNEAGIFRMDRLTGEIFVTRPNMLSSRTQPYHRLNISASDGGGLRSTHDAEV 790

  Fly   430 VVKVLNASR---------------------------------------LDYDVV--DPDLRKFEF 453
            .:.|::|::                                       |.|.:.  ||| ..|..
Mosquito   791 FISVIDATQRPPIFDKPRYTYYVKEDVKRNTVVGTVSATSSNSGNRGSLRYFIYSGDPD-GFFAI 854

  Fly   454 DLVASVKGVEKA------------------------KTRVEIHLLDANDNAPVFDQGTYRFTAAE 494
            |.|:....|..|                        .|:|.|.:.|.|||.|.|:..|.|.:..|
Mosquito   855 DPVSGNIRVANALDHETKPQVLLNIQATSGDPPAYGHTQVNIDIEDVNDNPPEFESNTVRISVPE 919

  Fly   495 NLPVDAIIGHVKATDLDSGEFGHVRYVLKGFG-------ADNFYVNPETGGVYLLKPLDYEKQSS 552
            |:.:.:.:....|.|.|||..|.:.|:|.|.|       :..|.::..:|.:.|.:|||||....
Mosquito   920 NVEIGSPLYEANAQDKDSGMSGVITYMLAGQGNTLSGARSSLFSMDSRSGHLTLARPLDYESMQR 984

  Fly   553 YSLTVVAIDGGQREANANL--FVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAHDADGP 615
            ::|.|.|.|.|....:.||  .|.|.|||||.|.||..||:.::.|..........|.|.|||
Mosquito   985 HTLVVTASDSGTPSLSTNLTILVEVQDVNDNAPIFEKNEYAISVIESTPSNSQILQVSATDAD-- 1047

  Fly   616 SQGNGRVKYSIVSE--------------NSIAGNVFRIEPDTGEIVIQKAARSMDTE-RGEYELV 665
            :..|.|:.|.|:.|              :.....:|.|.|::|.|.::   ..:|.| :..|.:.
Mosquito  1048 TGNNARLTYKILGEDHQRTGKSTQPASPDEPVAEIFGIFPNSGWIYLR---TKLDREVKERYNIT 1109

  Fly   666 VSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSNVTS 730
            |..:|.|:|.|:.|..|:|.: :..|            :|.||.....|...|.||...|:.:.:
Mosquito  1110 VIVSDNGVPTLTATAHVIVTI-LDAN------------DNSPIFAKSLYEFEIEENMRRGAMIGT 1161

  Fly   731 VSAHDPD-GLDSLLRYRIVGANDNFEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSGTPIP 794
            |||.|.| |:::::||.::.:|.:|:|:.:||.||.  :..:||::.. |::::|.|.|.|||.
Mosquito  1162 VSASDSDAGINAVVRYSLIPSNTSFQINPVSGEITT--RDSLDRETKA-SYDLVVEARDQGTPY- 1222

  Fly   795 ETATTTVYVNVKDINDERPKF-EQNSYATYVSERTAVGESVLRVKAIDKD--LNSKLEYSMVGPV 856
            .::..:|.|.:.|:||..|.. :.......|.|...:|..|::|:|||:|  .|:.:.||:
Mosquito  1223 RSSRVSVKVQILDVNDNAPDIVDPQEDVVSVREEQPIGTEVVKVRAIDRDHGQNASISYSI---- 1283

  Fly   857 AATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDLNAEVDPEGQVD 921
                   :...:...|.:   |.:|..||.|....:|.|:...|....|...| |.: .|:..|.
Mosquito  1284 -------LKGRDSDGYGM---FSIDPMSGVIRTKTSLDHEEKTIYRLAVAATD-NGK-PPKQTVR 1336

  Fly   922 TTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPI-------------DSALFILQAED- 972
            ...:.|.  ...|..|.|     |||..|.  :::|::.:             |:..||..:.|
Mosquito  1337 LLRIEVL--DLNDNRPTF-----TSSSLVF--RLREDVGVGHIIGSISGNEQSDAENFISSSSDL 1392

  Fly   973 --PVTRQPITSFELIEPKQVDYFQVAERTGEVILKKRLDYEALGDTGPEFELQVRA---NSADRQ 1032
              ..|..|:|: ::.|    ..|.:...:|::::.::||.|...    |:.:::||   ::::..
Mosquito  1393 HITYTLTPLTN-DITE----GAFDIDRNSGKLVVARQLDREQQS----EYRMEIRALDTSASNNP 1448

  Fly  1033 RSTVSRVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKII 1097
            :|:...|.|.:.:||||.|::..:.....:.|:.|....|......|.|...|| :.:....|..
Mosquito  1449 QSSAVTVKIEIADVNDNPPKWPSDPINVYVSEDTPVGAIVYNFTVQDNDTGTNA-EIKYNLSKPA 1512

  Fly  1098 YSLQGEHAMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLD 1162
            :..|.|:   |.|::.||.:.:.:  .:|.|.|....|.::|.|.....|:...:....:|.|.|
Mosquito  1513 HLAQKEY---FAIDSLTGSLTLLA--PLDHEDTQEFLLIVQATDQSSNVTERLTTSATARIIVTD 1572

  Fly  1163 VNDNAPEFTQKKYSTVIPENA----------QIDSFVLQLEAVDADEGLGGEVRYELV--NEGEA 1215
            ||||:|:|       |||:.|          :||..|..:.|:|.|.|..|.:.|..|  ||.|.
Mosquito  1573 VNDNSPKF-------VIPQAADGVVYISDSLEIDQVVSHVVAIDPDSGENGHIAYTFVGGNEDER 1630

  Fly  1216 NGLFKIDTKSGLI-------------STRRN-LTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDT 1266
               |.||:.:|:|             |.:|| ::||     |.|::.|.|:|:..|::..::
Mosquito  1631 ---FTIDSSTGVIRLAKPFSSNFIMDSGKRNSVSGK-----YQLVISASDHGSPRPREAKMT--- 1684

  Fly  1267 DVRIYIGDVSANDGVPYFLSPRVGQMANVTENAVTGAPVFQVIASDPDDESTPSG-TITYRILPD 1330
             :::.|.:::.|.  |.|:.|  ....|:|||..:|:.|.:|.|....|..:.:| .:||.| |.
Mosquito  1685 -LQVVIQNMTNNP--PRFVEP--VYHVNITENVPSGSFVVRVSARSHSDGGSGAGLNLTYEI-PK 1743

  Fly  1331 TPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNG---QPKQSA----------TRILQI 1382
            ....:.|.:|:..|::|||.:.|||:||:|.|.:.|::.|   :|..||          ...|.:
Mosquito  1744 GVGEDHFAVDSVRGIVTTRGTFDRESKDLYTIPIYVTEGGRFKKPSSSAASSQDMAQFDVATLVV 1808

  Fly  1383 AILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLFT 1447
            .:.||:||.|.|. :....||::....|.   :|:....|.|.|.|.|..|.|.|..||....|:
Mosquito  1809 RVTDVNDHAPEFV-QGSCYPLAVPENSEL---SIIHTVVATDADDGLNGEITYSISGGNMGNKFS 1869

  Fly  1448 IERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVLDIDD 1512
            |:.:..:|    |.:|:|||....:.|.|..        :..|.|...|  .|..|.:||.|.:|
Mosquito  1870 IDLHTGAL----TARPLDREVHARYVLQITA--------QDRGSPVSHQ--GHCNITIRVEDEND 1920

  Fly  1513 NLPKFEQPDPTVGIRINVPIDTVVTTLKASDADAEAPPVGL------SIENVTFVPQFYKRSRSL 1571
            |.||||.......|..:..|.|.|.|:||.|||     ||:      |:.|||
Mosquito  1921 NDPKFELQKYIATIDEDAQIGTTVLTVKAIDAD-----VGINARIVYSLANVT------------ 1968

  Fly  1572 AVGNLHNLFTLNNRTGELRTGGSF-ADYVDGYFLMRVMANNSVQPKRQAHSNLKVFVIRDKSLLK 1635
                 ..||.::::||.:.|.|.| .:..:.|..|.|..:......|..:..::| :|.|.:..|
Mosquito  1969 -----EWLFDIDSKTGVITTAGLFDRERQNVYNFMVVAMDGGRYNARSQNVPVQV-IIADVNDNK 2027

  Fly  1636 FVFARPPNEIQHNIRPFQEQLQKKLKPLGLELHVLDTQ---------VFTRPDMSLDFTATSSCF 1691
            .||.:         .||:||:...::|....||:..|.         |:     ||:..|::..|
Mosquito  2028 PVFDK---------YPFREQIGALVQPGQTLLHISATDSDQGSNGEIVY-----SLNENASNGKF 2078

  Fly  1692 QMFKNGAALSFNEMQKLMNSQQLRQEL 1718
            ::.....|||..:.....|.:.|..|:
Mosquito  2079 RINPTTGALSATQSLASENGRLLHIEV 2105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad74A	NP_648973.1	Cadherin_repeat	33..124	CDD:206637	30/102 (29%)
		Cadherin_repeat	132..240	CDD:206637	34/212 (16%)
		Cadherin_repeat	249..361	CDD:206637	34/113 (30%)
		Cadherin_repeat	487..581	CDD:206637	34/102 (33%)
		Cadherin_repeat	589..686	CDD:206637	29/111 (26%)
		Cadherin_repeat	713..810	CDD:206637	32/97 (33%)
		Cadherin_repeat	819..936	CDD:206637	28/118 (24%)
		Cadherin_repeat	953..1049	CDD:206637	22/114 (19%)
		Cadherin_repeat	1057..1166	CDD:206637	26/108 (24%)
		Cadherin_repeat	1175..1279	CDD:206637	34/129 (26%)
		Cadherin_repeat	1293..1390	CDD:206637	35/110 (32%)
		Cadherin_repeat	1402..1513	CDD:206637	32/110 (29%)
		Cadherin_repeat	1523..1628	CDD:206637	28/111 (25%)
ds	XP_061514261.1	None