Protein Alignment Cad74A and ft

DIOPT Version :10

• Sequence 1: NP_648973.1
• Gene: Cad74A / 39936
• FlyBaseID: FBgn0036715
• Length: 1820
• Species: Drosophila melanogaster
• Sequence 2: XP_061517696.1
• Gene: ft / 1278031
• VectorBaseID: AGAMI1_013412
• Length: 5196
• Species: Anopheles gambiae
• Alignment Length: 1869
• Identity: 493/1869 - (26%)
• Similarity: 778/1869 - (41%)
• Gaps: 473/1869 - (25%)

  Fly    19 NQPPQF--VPGTGDMSRFSLSENTPVGSPVFQLKGTDPEG-GRLKYSI----SGPVFSVDRETGV 76
            :.||:|  :|..     ||:||:..||..|.::..|||:. |:|:|::    :...|:::||||:
Mosquito  1798 DSPPKFQNLPLV-----FSVSEDLAVGQTVARITATDPDTLGKLEYALLDGDAPKKFALERETGL 1857

  Fly    77 VRLRQELDRETQDTVEVIISITDEGIYGTEPNTVSQRRVIPVRDYNDNQPTFLGRPYTASVSESL 141
            ::||..|||||:|:..:.:|:|| ||..|| .|::    |.:.|.|||.|.|....|:..:.|:.
Mosquito  1858 LKLRDTLDRETEDSYRLKVSVTD-GIQSTE-TTIT----IQITDTNDNPPVFAEPAYSFDIPENA 1916

  Fly   142 PVGSELSVEPPIVVVDRDEGINSEVQMKCLEE--NDICDIFEVRAVKISDGNYTARVALKQQLDF 204
            ..|..:.|   |...|.|.|.|:.|....:.:  ||:          .|....|....|..:||:
Mosquito  1917 QRGFHVGV---IAATDPDVGTNAAVTYTVISDWANDV----------FSLNPQTGIFTLTARLDY 1968

  Fly   205 ESRPSYILTISASDSALDNRLSSLATISINVIDIQDQPPIFTNAPYSATVPENTPAGVSILTVKA 269
            |....|||.:.|.|:...: |||..|:..||:|:.|..|||....||..:.||.|....::||.|
Mosquito  1969 EEVQHYILVVQAQDNGYPS-LSSTLTVYCNVVDLNDNAPIFDPMSYSNEIFENAPINSDVVTVSA 2032

  Fly   270 VDGDVGIPREIFLSLEDEPFGHFELVPFGDPRDGTAVLQTTSEPLDRENAEILQNGGVYVFSIRA 334
            .|.|.|....|..|           :..||               |.|:.:|:.||     :||.
Mosquito  2033 TDIDSGSNGRIEYS-----------ITAGD---------------DNEDFQIMSNG-----TIRT 2066

  Fly   335 TELIDGAIPAEHSL------------------TRVTIVVTDVDDHQPTFSGPHFNVSITENLANG 381
            ...:|....:.:||                  .:||||:.|::|..|.|..|: ..|:.||:...
Mosquito  2067 RRALDRETKSSYSLVVTARDCAKEPEKRLSSTVQVTIVLKDINDLAPEFVTPN-ETSVAENIPPN 2130

  Fly   382 MPLPGLSIFVDDRDMGENSRYELSLRDVFNAARVFEVSPTESQGRTPVVVKVLNA-------SRL 439
            ..:  ::|...|||.|.|...|..|.|              .||..|....|..|       .:|
Mosquito  2131 TVI--MAIKAVDRDEGRNGYVEYQLED--------------DQGSLPSPFTVGQADGLLRVSGQL 2179

  Fly   440 DYDVVDPDLRKFEFDLVASVKG--VEKAKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAII 502
            |.:...    .:|.:::|..:|  ....::|:.|::||.|||:|:||...|....|||..:.|.:
Mosquito  2180 DREAKP----SYELNVIAKDRGDPPRMTQSRIRINVLDENDNSPIFDPKQYSAAIAENASIGASV 2240

  Fly   503 GHVKATDLDSGEFGHVRYVLKGFGADN--FYVNPETGGVYLLKPLDYEKQSSYSLTVVAID---- 561
            ..|.|||:|.|..|.||:.:.. |.||  |.::.::|.|.:.|.|::|::|.|::||.|.|
Mosquito  2241 LQVSATDIDEGANGRVRFSIAA-GDDNRDFTISEDSGVVRVAKNLNFERKSLYAITVRAEDCAGD 2304

  Fly   562 ---GGQREANANLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQ----FFVRAHDADGPSQGN 619
               |..|...|.|.:.:||:|||.|.|....|...:.|.  :..|.    ..|||:|||.| ..|
Mosquito  2305 TENGEVRFDTARLSITITDINDNPPTFLDSPYLAYVMEN--VIPPNNGYVITVRAYDADTP-PFN 2366

  Fly   620 GRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTE-RGEYELVVSATDFGIPPLSNTTRVL 683
            .:|:|.:...::   :.|:|...||||.:   .|::|.| :.||.|.:.|.|.|.|||:.|..|.
Mosquito  2367 SQVRYFLKEGDT---DFFKINASTGEISL---LRALDREMQEEYILTLVAMDTGSPPLTGTGTVR 2425

  Fly   684 VRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSNVTSVSAHDPD-GLDSLLRYRI 747
            |.|....:..|.|...             ||:.:|.||...|:.|....|.|.| ||::.:||.:
Mosquito  2426 VMVQDINDHNPEFERQ-------------SYQATIAENQPIGTRVLWPRATDRDAGLNAKIRYTL 2477

  Fly   748 VGANDN-FEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDE 811
            :|.:.: |.:|..||.||.:  |.:||: :|..:...:.|.||.|..|......:.::|:|:||.
Mosquito  2478 LGEHSSRFRLDASSGEITTA--AVLDRE-DMPIYHFTLMAQDSSTTEPRATLVNLTIDVQDVNDN 2539

  Fly   812 RPKFEQNSYATYVSERTAVGESVLRVKAIDKD--LNSKLEYSMVG-------------------- 854
            .|.|...::...|.:|...|:.|...||||:|  :|::|.||:||
Mosquito  2540 SPAFGAPTFHVNVPDRIKPGQFVFGAKAIDRDEGVNARLLYSIVGTDAAKFRINEHTGVIEAATE 2604

  Fly   855 --------------------------PVAATTKAGVSIANRSNY--------------------- 872
                                      |.:||.:..:|:.:...:
Mosquito  2605 LSTPMSGANSERVFRLTIVAKDEGYEPRSATCELAISLRSAHLFPVFSYTSETQFVLPEDIADGK 2669

  Fly   873 -------------------------RLQEAFRVDSQSGEIFVN-GTL---RHDVAAIIIFTVGVR 908
                                     .:.||.|:|..:||:.|| |.|   ||....:.|..
Mosquito  2670 MVTKLAATSPKKGSVGTIRYAIAGGNIGEALRIDPSTGEVAVNRGGLDYERHQQYEVWIEA---- 2730

  Fly   909 DLNAEVDPEGQVDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDP 973
               |:.|........::.|.|....|..||.       .||:...::.||            |.|
Mosquito  2731 ---ADSDRPSLRSVLQLIVNVTDANDNAPVM-------DRPMYVAEVLEE------------ESP 2773

  Fly   974 ---VTRQPITSFELIEPKQVDY--------FQVAERTGEVILKKRLDYEAL-------------- 1013
               ||:...:..:..|..|:.|        |::...|||:....|||.|.:
Mosquito  2774 SQLVTKVSASDADSEENGQITYRLRDDFESFEINTDTGEIYTTTRLDREDIAQYTLIVEAVDQGV 2838

  Fly  1014 ----------------GDTGPEF--------------------------ELQVRANSA------- 1029
                            .|..|:|                          ::.|.||:.
Mosquito  2839 PQLTGSATVLVNVLDKNDNPPKFTRLFSVNVTENAEIGQFVIKITSSDSDVGVNANATYIFTENL 2903

  Fly  1030 -------------------DRQRS---------------TVSRVNITVENVNDNSPRFERNSYQA 1060
                               ||::.               |.:.:.||:::.|||:|.||.:.|..
Mosquito  2904 GGKFSIDSTTGNVTVAGHLDREQQDEYILKVAAVDGAWRTETPLTITIQDQNDNAPEFEHSYYSF 2968

  Fly  1061 TIIENRPHPERVIRVRALDKDAVLNARDERLGYHKII-YSLQGEHAMLFDINNTTGEIIVASGQT 1124
            ...|.:.....|.:|.|.|:|        :.|.:.:| |||| :.:.||.|:..||||.  |.:.
Mosquito  2969 NFRELQKSVTFVGQVIATDRD--------KQGPNSVISYSLQ-QPSDLFTIDPATGEIF--SKRR 3022

  Fly  1125 IDRERTPRIQLQIKAEDS---------PGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIP 1180
            |..:.|   ||:...|:|         .|:|....:.:|  .|.|:|.|:|.|.|:|:.|...:|
Mosquito  3023 IHYKHT---QLEASPENSFTLTVLATDNGKPPMYTECLV--NINVVDANNNPPVFSQRAYMAPVP 3082

  Fly  1181 ENAQIDSFVLQLEAVD-ADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHP-- 1242
            |.|.:...:|||.|.| .|.|:..|:.|:|:. |..:..|.|:...|.|...|.|: :..|.|
Mosquito  3083 EGADVGVRILQLTARDELDFGVNAEIEYQLIG-GNGSDRFAINKLDGWIVVGRKLS-EVAASPGT 3145

  Fly  1243 -YVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTENAVTGAPVF 1306
             :||.|||.|.|  :|.|     ..:|.:.:....||...|.|.||  .....|.||...|:.:.
Mosquito  3146 VFVLQVRAIDRG--VPPQ-----QDEVSVTLIVTGANRFAPVFQSP--SYQVIVPENEPIGSTIL 3201

  Fly  1307 QVIASDPDDESTPSGTITYRILPDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNG- 1370
            .|  |.||::..|:|.:.|.||... :...|::::.:|.::.|..:|.:...:|::.:...|.|
Mosquito  3202 TV--SAPDNDDGPNGMVRYAILAGN-ERNDFMVNSVTGAVSIRNPLDYDLIQVYQLNITAEDLGY 3263

  Fly  1371 QPKQSATRILQIAILDVDDHEPRFAREA-DAGPLSMSVREEEPAGTIVGNFSALDEDLGENAAID 1434
            :||:|.. ::.|.:.|::|:.|.|.:.. ||     .|.|..||.|.|....|.|.|..:||.|:
Mosquito  3264 KPKRSIA-MVTITLTDINDNAPYFNQSVYDA-----YVAENSPANTFVYRAQAHDRDSPKNAIIN 3322

  Fly  1435 YVIIDGNNEQLFTIERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQDLS 1499
            |.|:.|:..:||.||   .:..|:.:|...|.|:.:.:|||:...           :| |....:
Mosquito  3323 YAIVGGSGRELFAIE---TATGIITSKATFDYEEQDQYTLTLAAY-----------NP-DSSMRN 3372

  Fly  1500 HLRINVRVLDIDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADA-EAPPVGLSIENVTFVPQ 1563
            ..::.|.|..:::..|||.||.....:..:..:.:.|..::|:|.|| |...|
Mosquito  3373 ETKVIVHVTGVNEYFPKFIQPVFHFDVSESAEVGSSVGIIEATDKDAGEDGKV------------ 3425

  Fly  1564 FYKRSRSLAVGNLHNL-FTLNNRTGELRTGGSFADYVDGYFLMRVMANN 1611
            :|     |.||:.::. |:::..||.|....:.........::.|:|.|
Mosquito  3426 YY-----LLVGSSNDKGFSIHPSTGVLVVSRNLDRETQSRVVLTVLAKN 3469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad74A	NP_648973.1	Cadherin_repeat	33..124	CDD:206637	37/95 (39%)
		Cadherin_repeat	132..240	CDD:206637	30/109 (28%)
		Cadherin_repeat	249..361	CDD:206637	30/129 (23%)
		Cadherin_repeat	487..581	CDD:206637	36/102 (35%)
		Cadherin_repeat	589..686	CDD:206637	34/101 (34%)
		Cadherin_repeat	713..810	CDD:206637	32/98 (33%)
		Cadherin_repeat	819..936	CDD:206637	37/214 (17%)
		Cadherin_repeat	953..1049	CDD:206637	29/203 (14%)
		Cadherin_repeat	1057..1166	CDD:206637	34/118 (29%)
		Cadherin_repeat	1175..1279	CDD:206637	34/107 (32%)
		Cadherin_repeat	1293..1390	CDD:206637	25/97 (26%)
		Cadherin_repeat	1402..1513	CDD:206637	30/110 (27%)
		Cadherin_repeat	1523..1628	CDD:206637	18/91 (20%)
ft	XP_061517696.1	None