DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and Celsr1

DIOPT Version :9

Sequence 1:NP_001246814.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:XP_006520442.1 Gene:Celsr1 / 12614 MGIID:1100883 Length:3039 Species:Mus musculus


Alignment Length:1555 Identity:371/1555 - (23%)
Similarity:597/1555 - (38%) Gaps:375/1555 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   243 PIFTNAPYSATVPENTPAGVSILTVKAVDGDVGIPREIFLSLE---DEPFGHFELVPFGDPRDGT 304
            |.|....|..:||||.|||.:::.::|.|.|.|....:...:|   ||....:.|:      |..
Mouse   258 PQFPLPSYQVSVPENEPAGTAVIELRAHDPDEGDAGRLSYQMEALFDERSNGYFLI------DAA 316

  Fly   305 AVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPTFSGPH 369
            ....||:..||||..:      .:|..:.|   :|...|...:.|.:|:.|:|.:||.|.|....
Mouse   317 TGAVTTARSLDRETKD------THVLKVSA---VDHGSPRRSAATYLTVTVSDTNDHSPVFEQSE 372

  Fly   370 FNVSITENLANGMPLPGLSIFVDDRDMGENS--RYELSLRDVFNAARVFEVSPTESQGRTPVVVK 432
            :...|.|||..|..:  |:|...|.|...|:  ||.|    :..|..|||:.......||..||.
Mouse   373 YRERIRENLEVGYEV--LTIRATDGDAPSNANMRYRL----LEGAGGVFEIDARSGVVRTRAVVD 431

  Fly   433 VLNASRLDYDVVDPDLRKFEFDLVASVK------GVEKAKTRVEIHLLDANDNAPVFDQGTYRFT 491
            ...|:              |:.|:....      |...|...|.|.:.|.|||.|.|.:..|...
Mouse   432 REEAA--------------EYQLLVEANDQGRNPGPLSASATVHIVVEDENDNYPQFSEKRYVVQ 482

  Fly   492 AAENLPVDAIIGHVKATDLDSGEFGHVRY-VLKGFGADNFYVNPETGGVYLLKPLDYEKQSSYSL 555
            ..|::.|:..:..|:|||.|.|:...:.| ::.|.....||::..:|.:.::.|||:|....|:|
Mouse   483 VPEDVAVNTAVLRVQATDRDQGQNAAIHYSIVSGNLKGQFYLHSLSGSLDVINPLDFEAIREYTL 547

  Fly   556 TVVAIDGGQR---EANANLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAHDADGPSQ 617
            .:.|.|||:.   .::..:.|.|.|||||.|.|.|..:...:.|...|......::|.|||... 
Mouse   548 RIKAQDGGRPPLINSSGLVSVQVLDVNDNAPIFVSSPFQAAVLENVPLGHSVLHIQAVDADAGE- 611

  Fly   618 GNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTERGEYELVVSATDFGIPPLSNTTRV 682
             |.|::|.:|              ||...::  ...|:|:|.     ..||.||           
Mouse   612 -NARLQYRLV--------------DTASTIV--GGSSVDSEN-----PASAPDF----------- 643

  Fly   683 LVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSNVTSVSAHDPDGLDSLLRYRI 747
                                                                             
Mouse   644 ----------------------------------------------------------------- 643

  Fly   748 VGANDNFEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSGTPIPETATTTVYVNVKDINDER 812
                 .|:|...||.|||.  |.:||: .:..:...|.|||.|:| ..:::.:|.:.|.|:||..
Mouse   644 -----PFQIHNSSGWITVC--AELDRE-EVEHYSFGVEAVDHGSP-AMSSSASVSITVLDVNDND 699

  Fly   813 PKFEQNSYATYVSERTAVGESVLRVKAIDKDLNSKLEYSMVGPVAATTKAGVSIANRSNYRLQEA 877
            |.|.|..|...::|..|||.|||.::|.|:|.||.:.|.:.|            .|..|     .
Mouse   700 PMFTQPVYELRLNEDAAVGSSVLTLRARDRDANSVITYQLTG------------GNTRN-----R 747

  Fly   878 FRVDSQSGEIFVNGTL-------RHDVAAIIIFTVGVRDLNAEVDPEGQVDTTEVTVYVQSFQDT 935
            |.:.||||...:...|       |..|.|:.. :.|.|...|:|    .::.|:...:       
Mouse   748 FALSSQSGGGLITLALPLDYKQERQYVLAVTA-SDGTRSHTAQV----FINVTDANTH------- 800

  Fly   936 NPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQPI-TSFELIEPKQVDYFQVAERT 999
            .|||:::.:|       |.:.|:.|:.:::..:.|.|..|.:.. .::.|.:|  |..|::...|
Mouse   801 RPVFQSSHYT-------VSVSEDRPVGTSIATISATDEDTGENARITYVLEDP--VPQFRIDPDT 856

  Fly  1000 GEVILKKRLDYEALGDTGPEFELQVRA-NSADRQRSTVSRVNITVENVNDNSPRFERNSYQATII 1063
            |.:.....||||    ....:.|.:.| ::...|:|..:.:.|.:.:.|||:|||.|:.||.::.
Mouse   857 GTIYTMTELDYE----DQAAYTLAITAQDNGIPQKSDTTSLEILILDANDNAPRFLRDFYQGSVF 917

  Fly  1064 ENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQG--EHAMLFDINNTTGEIIVASGQTID 1126
            |:.|....|::|.|.|:|:..|.|        ::|:.||  :....|.|..|:|  ::.:.:.:|
Mouse   918 EDAPPSTSVLQVSATDRDSGPNGR--------LLYTFQGGDDGDGDFYIEPTSG--VIRTQRRLD 972

  Fly  1127 RERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQIDSFVLQ 1191
            ||......|...|.|. |.|.....| |.:|:.|||:|||.|.|.:.:....:.||:.:.|.|.:
Mouse   973 RENVAVYNLWALAVDR-GSPNPLSAS-VGIQVSVLDINDNPPVFEKDELELFVEENSPVGSVVAR 1035

  Fly  1192 LEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIVRAQDNGNQM 1256
            :.|.|.|||...::.|::| ||....:|::|..||.:.....|..:.| ..|:|:|:|       
Mouse  1036 IRANDPDEGPNAQIMYQIV-EGNVPEVFQLDLLSGDLRALVELDFEVR-RDYMLVVQA------- 1091

  Fly  1257 PKQPTLSTDTDVRIYIGDVSANDGVP------YFLSPRVGQMANVTENAVTGAPVFQVIASDPDD 1315
            ...|.:|..|   ::|..:..||..|      ...:..|...:|...:.|.|    ::.|.||| 
Mouse  1092 TSAPLVSRAT---VHIRLLDQNDNPPELPDFQILFNNYVTNKSNSFPSGVIG----RIPAHDPD- 1148

  Fly  1316 ESTPSGTITYRILPDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVS-DNGQPKQSATRI 1379
               .|.::.|..|... :....::|..:|.:  :.|.|.:.......|:||| .:|....:|...
Mouse  1149 ---LSDSLNYTFLQGN-ELSLLLLDPATGEL--QLSRDLDNNRPLEALMEVSVSDGIHSVTALCT 1207

  Fly  1380 LQIAILDVDD--------HEPRFAREADAGP-LSMSVREEEPAGTIVGN-------FSAL-DEDL 1427
            |::.|: .||        .....::|....| ||:.|   |...|::..       |:.. |.|:
Mouse  1208 LRVTII-TDDMLTNSITVRLENMSQEKFLSPLLSLFV---EGVATVLSTTKDDIFVFNIQNDTDV 1268

  Fly  1428 GE---NAAIDYVIIDGNNEQLFTIERNNESLAILKT-KKPIDREQVESFTLTIKCLKLGEPGYKF 1488
            ..   |.....::..|...:.|..|...|.:.:.:| ...|..::|..|...| ||:  ||...:
Mouse  1269 SSNILNVTFSALLPGGTRGRFFPSEDLQEQIYLNRTLLTTISAQRVLPFDDNI-CLR--EPCENY 1330

  Fly  1489 IGDPYDRQDLSHLRINVRVLDIDDNLPKFEQPDPTVGIRINVP-------IDTVVTTLKASDADA 1546
            :      :.:|.||.:.....|......|....|..|:|...|       .:|.:....::...|
Mouse  1331 M------KCVSVLRFDSSAPFISSTTVLFRPIHPITGLRCRCPPGFTGDYCETEIDLCYSNPCGA 1389

  Fly  1547 EAPPVGLSIENVTFVPQFYKRSRSLAVGNLHNLF--------TLNNRTGE-----LRTGGSFADY 1598
            ..                  |.||...|.....|        .:|.|:|.     .:.||:..:.
Mouse  1390 NG------------------RCRSREGGYTCECFEDFTGEHCQVNVRSGRCASGVCKNGGTCVNL 1436

  Fly  1599 VDGYFLMRVMANNSVQPKRQAHSNLKVFVIRDKSLLKFVFARPPNEIQH-----NIRPFQEQLQK 1658
            :.|.|                |.                 ..||.|.:|     :.|.|..|...
Mouse  1437 LIGGF----------------HC-----------------VCPPGEYEHPYCEVSTRSFPPQSFV 1468

  Fly  1659 KLKPLGLELHVLDTQVFTRPDMSLDFTATSSCFQMFKNGAALSFNEMQKLMNSQQLRQEL 1718
            ..:.|....|      ||   :||.|........:..||   .|||....:..:.:.::|
Mouse  1469 TFRGLRQRFH------FT---VSLAFATQDRNALLLYNG---RFNEKHDFIALEIVEEQL 1516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_001246814.1 Cadherin_repeat 33..124 CDD:206637
Cadherin_repeat 132..240 CDD:206637
Cadherin_repeat 249..361 CDD:206637 31/114 (27%)
Cadherin_repeat 369..479 CDD:206637 30/117 (26%)
Cadherin_repeat 487..581 CDD:206637 29/97 (30%)
Cadherin_repeat 589..686 CDD:206637 19/96 (20%)
Cadherin_repeat 713..810 CDD:206637 19/96 (20%)
Cadherin_repeat 819..936 CDD:206637 31/123 (25%)
Cadherin_repeat 953..1049 CDD:206637 22/97 (23%)
Cadherin_repeat 1057..1166 CDD:206637 33/110 (30%)
Cadherin_repeat 1175..1279 CDD:206637 27/103 (26%)
Cadherin_repeat 1293..1390 CDD:206637 24/105 (23%)
Cadherin_repeat 1402..1513 CDD:206637 27/123 (22%)
Cadherin_repeat 1523..1628 CDD:206637 18/124 (15%)
Celsr1XP_006520442.1 Cadherin_repeat 264..364 CDD:206637 31/114 (27%)
Cadherin_repeat 372..470 CDD:206637 30/117 (26%)
Cadherin_repeat 479..576 CDD:206637 29/96 (30%)
Cadherin_repeat 584..698 CDD:206637 39/221 (18%)
Cadherin_repeat 706..800 CDD:206637 31/115 (27%)
Cadherin_repeat 808..903 CDD:206637 23/107 (21%)
Cadherin_repeat 912..1010 CDD:206637 33/109 (30%)
Cadherin_repeat 1018..1112 CDD:206637 28/105 (27%)
Cadherin_repeat 1132..1213 CDD:206637 21/91 (23%)
EGF_CA 1379..1414 CDD:238011 6/52 (12%)
EGF_CA 1422..1456 CDD:238011 9/66 (14%)
LamG 1459..1642 CDD:238058 16/70 (23%)
EGF_CA 1666..1700 CDD:238011
Laminin_G_2 1734..1861 CDD:366983
EGF_CA 1889..1923 CDD:238011
EGF_CA 1923..1961 CDD:238011
TNFRSF <1930..2026 CDD:389949
CRD3 1951..2000 CDD:276900
CRD4 2002..2026 CDD:276900
EGF_Lam 2017..>2055 CDD:238012
HormR 2067..2128 CDD:214468
GAIN 2145..2396 CDD:374574
GPS 2422..2475 CDD:197639
7tmB2_CELSR1 2480..2733 CDD:320657
TM helix 1 2483..2507 CDD:320657
TM helix 2 2516..2537 CDD:320657
TM helix 3 2547..2569 CDD:320657
TM helix 4 2588..2604 CDD:320657
TM helix 5 2623..2646 CDD:320657
TM helix 6 2666..2691 CDD:320657
TM helix 7 2695..2720 CDD:320657
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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