Protein Alignment Cad74A and FAT3

DIOPT Version :9

• Sequence 1: NP_001246814.1
• Gene: Cad74A / 39936
• FlyBaseID: FBgn0036715
• Length: 1820
• Species: Drosophila melanogaster
• Sequence 2: XP_016872667.1
• Gene: FAT3 / 120114
• HGNCID: 23112
• Length: 4612
• Species: Homo sapiens
• Alignment Length: 1770
• Identity: 461/1770 - (26%)
• Similarity: 738/1770 - (41%)
• Gaps: 385/1770 - (21%)

  Fly    35 SLSENTPVGSPVFQLKGTDPEGGR----LKYSISGP--VFSVDRETGVVRLR-QELDRETQDTVE 92
            |:|||   .:.:.::...:..|.|    |||||..|  .|.:...:||::.. ...|||.|:..|
Human  2013 SISEN---NTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYE 2074

  Fly    93 VIISITDEGIYGTEPNTVSQRRV------IPVRDYNDNQPTFLGRPYTASVSESLPVGSELSVEP 151
            :::..:.|         :...||      :.:.|.|||.|.|:|.||.|:|        ::..||
Human  2075 LVVEASRE---------LDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAV--------QVDAEP 2122

  Fly   152 -----PIVVVDRDEGINSEVQMKCLEENDICDIFEVRAVKISDGNYTARVALKQQLDFESRPSYI 211
                 .:..:|:|:|.|.||....   .|....||:..   :.||...:.|....|   |...|.
Human  2123 GTLIYQVTAIDKDKGPNGEVTYVL---QDDYGHFEINP---NSGNVILKEAFNSDL---SNIEYG 2178

  Fly   212 LTISASDSALDNRLSSLATISINVIDIQDQPPIFTNAPYSATVPENTPAGVSILTVKAVDGD-VG 275
            :||.|.|....: ||:...:.|.:::  ...|:|....|:|:|.|:......||::.|...: .|
Human  2179 VTILAKDGGKPS-LSTSVELPITIVN--KAMPVFDKPFYTASVNEDIRMNTPILSINATSPEGQG 2240

  Fly   276 IPREIFLSLEDEPFGHFELVPFGDPRDGTAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDG 340
            |   |::.::.:||..|. :.|     .|.||:..| |||.|..      ..|..:|||::.:.|
Human  2241 I---IYIIIDGDPFKQFN-IDF-----DTGVLKVVS-PLDYEVT------SAYKLTIRASDALTG 2289

  Fly   341 AIPAEHSLTRVTIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIFVDDRDMGENSR---Y 402
            |    .:...|.::|.||:|:.|.|..|.:|.:::|....|.|:  |.:...|.| .||::   |
Human  2290 A----RAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPV--LQVVSIDAD-SENNKMVHY 2347

  Fly   403 ELSLRDVFNAARVFEVSPTESQGRTPVVVKVLNASRLDYDVV----------------------- 444
            :: ::|.:|:...|.:.  .|.|      .:|.|..||:::|
Human  2348 QI-VQDTYNSTDYFHID--SSSG------LILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLV 2403

  Fly   445 ---------------------------------------DPDLRKFE------------------ 452
                                                   |.|...|:
Human  2404 HIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMD 2468

  Fly   453 -------------------FDLVASVK-GVEKAKTRVEIHLLDANDNAPVFDQGTYRFTAAENLP 497
                               :.|..||. |:..:..:|.|.:|.||..:|.|.|.||.....||:.
Human  2469 SKSGVITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVA 2533

  Fly   498 VDAIIGHVKATDLDSGEFGHVRY-VLKGFGADNFYVNPETGGVYLLKPLDYEK--QSSYSLTVVA 559
            ....:.||:|||.|.|.:|.:.| ::..|..|.|.:: ..|.|...:.||.|.  :...|:.|.|
Human  2534 AGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLID-SNGQVITTERLDRENPLEGDVSIFVRA 2597

  Fly   560 IDGGQREANANLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFVRAH-----DADGPSQG- 618
            :|||.|.....:.|.|.|.|||.|.|.:.||..::|....        |.|     .|..|..|
Human  2598 LDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG--------RGHLVTQVQAIDPDDGA 2654

  Fly   619 NGRVKYSIVSENSIA-GNVFRIEPDTGEIVIQKAARSMDTERGEY--------ELVVSATDFGIP 674
            |.|:.||:.||.|:: .::..|:||.|.:|          .:|.:        ...|.|.|.|||
Human  2655 NSRITYSLYSEASVSVADLLEIDPDNGWMV----------TKGNFNQLKNTVLSFFVKAVDGGIP 2709

  Fly   675 PLSNTTRVLVRVGISGNQRPIFRGHFQNMEN-LPIIGPPSYRVSIPENAAAGSNV---------- 728
            ...:...|.:              |....|. ||......|..:|.|:.|.||.|
Human  2710 VKHSLIPVYI--------------HVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQN 2760

  Fly   729 ---TSVSAHDPDGLDSLLRYRIVGANDNFEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSG 790
               ::|:...|:.          .....|.|::.:|  |:....|:||::: .:|...|.|....
Human  2761 VWFSTVNGERPEN----------NKGGIFVIEQETG--TIKLDKRLDRETS-PAFHFKVAATIPL 2812

  Fly   791 TPIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKD--LNSKLEYSMV 853
            ..:....|..|.:.|.|:||.:|.||.:||.|.:.|...||..:.:|:|||.|  .|.::.||:
Human  2813 DKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSL- 2876

  Fly   854 GPVAATTKAGVSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDLNAEVDPEG 918
                        .::....::.|||.:||.:|.|.....|.|:......|:|...||       |
Human  2877 ------------HSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDL-------G 2922

  Fly   919 QV----DTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAED----PVT 975
            :.    .|..|:|.|....|..|||       ::.|....:||..|....:.:|...|    .|.
Human  2923 EAFSLSSTALVSVRVTDINDNAPVF-------AQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVN 2980

  Fly   976 RQPITSFELI--EPKQVDYFQVAERTGEVILKKRLDYEALGDTGPEFELQ-VRANSADRQRSTVS 1037
            ||  .|:.:.  .|:......:.:...:|.:|:.||.|       |.::. :...:.|....|.:
Human  2981 RQ--VSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-------EQDIYFLNITATDGLFVTQA 3036

  Fly  1038 RVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQG 1102
            .|.::|.:||||||..::.:|.|.:.|:.|..:.:::|.|.|.|...|      ||  |.|||.|
Human  3037 MVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSN------GY--IRYSLYG 3093

  Fly  1103 EHAMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNA 1167
            .....|.::..:||:...:  .:||||.|...|..||.|..||   ..||.:.|.:|  |||||.
Human  3094 SGNSEFFLDPESGELKTLA--LLDRERIPVYSLMAKATDGGGR---FCQSNIHLILE--DVNDNP 3151

  Fly  1168 PEFTQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRR 1232
            |.|:...|:|.:.||....:.:.:::|||.|.|:..:|.|.|.:  .|.|:|.||:.||:|...:
Human  3152 PVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLAD--SAGGVFSIDSSSGIIILEQ 3214

  Fly  1233 NLTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTE 1297
            .| .:.:...|.:.|||.|   |.|.| :||:.|.|.|.:.|:  ||..|.|  .|...:..|.|
Human  3215 PL-DREQQSSYNISVRATD---QSPGQ-SLSSLTTVTITVLDI--NDNPPVF--ERRDYLVTVPE 3270

  Fly  1298 NAVTGAPVFQVIASDPDDESTPSGT---ITYRILPDTPDAEAFVIDAHSGLITTRQSMDRETKDM 1359
            :...|..|..|.|:..|     .||   |||.|.......: |.|:..:|.|:..:.:|.|....
Human  3271 DTSPGTQVLAVFATSKD-----IGTNAEITYLIRSGNEQGK-FKINPKTGGISVSEVLDYELCKR 3329

  Fly  1360 YRILLEVSDNGQPKQSATRILQIAILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALD 1424
            :.:::|..|.|.|..||...:.|.:.||:|:.|:|:::.    .|..:.|:...|..|....|.|
Human  3330 FYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDV----YSAVISEDALVGDSVILLIAED 3390

  Fly  1425 EDLGENAAIDYVIIDGNNEQLFTIERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFI 1489
            .|...|..|.:.|::|:.:..||::   ..|.::|.||.:|||:|..::|.::.:..|.|...
Human  3391 VDSQPNGQIHFSIVNGDRDNEFTVD---PVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMS-- 3450

  Fly  1490 GDPYDRQDLSHLRINVRVLDIDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADA--EAPPVG 1552
                     |...:|:.:.|::||.|.|...:.|..|:.|.|:.|.:..|..:|.|:  ..||..
Human  3451 ---------STATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFS 3506

  Fly  1553 LSIENVTFVPQFYKRSRSLAVGNLHNLFTLNNRTGELRTGGSFADYVDGYFLMRVMANNSVQPKR 1617
            .||.:                ||....|.|:.. |.||:...|.......:::.|.|.:|.:|::
Human  3507 FSILS----------------GNEEEEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKDSGKPQQ 3554

  Fly  1618 QAHSNLKVFVIRDKS 1632
            .:|:.::|.||.:.:
Human  3555 VSHTYIRVRVIEEST 3569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad74A	NP_001246814.1	Cadherin_repeat	33..124	CDD:206637	25/101 (25%)
		Cadherin_repeat	132..240	CDD:206637	28/112 (25%)
		Cadherin_repeat	249..361	CDD:206637	32/112 (29%)
		Cadherin_repeat	369..479	CDD:206637	32/212 (15%)
		Cadherin_repeat	487..581	CDD:206637	32/96 (33%)
		Cadherin_repeat	589..686	CDD:206637	28/111 (25%)
		Cadherin_repeat	713..810	CDD:206637	23/109 (21%)
		Cadherin_repeat	819..936	CDD:206637	33/122 (27%)
		Cadherin_repeat	953..1049	CDD:206637	22/102 (22%)
		Cadherin_repeat	1057..1166	CDD:206637	37/108 (34%)
		Cadherin_repeat	1175..1279	CDD:206637	35/103 (34%)
		Cadherin_repeat	1293..1390	CDD:206637	28/99 (28%)
		Cadherin_repeat	1402..1513	CDD:206637	27/110 (25%)
		Cadherin_repeat	1523..1628	CDD:206637	26/106 (25%)
FAT3	XP_016872667.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910