Protein Alignment Cad74A and Cdh23

DIOPT Version :10

• Sequence 1: NP_648973.1
• Gene: Cad74A / 39936
• FlyBaseID: FBgn0036715
• Length: 1820
• Species: Drosophila melanogaster
• Sequence 2: XP_063134984.1
• Gene: Cdh23 / 114102
• RGDID: 619760
• Length: 3351
• Species: Rattus norvegicus
• Alignment Length: 1803
• Identity: 525/1803 - (29%)
• Similarity: 807/1803 - (44%)
• Gaps: 337/1803 - (18%)

  Fly     4 LLLPLFLSLTAGQLVNQPPQFVPGTGDMSRFSLSENTPVGSPVFQLKGTDPEGGRLKYSISGP-- 66
            |.|.:.:|.:.|| ||:.|.|.....| :...:||:|||||.|.||...|.:...|.:.:||.
  Rat    12 LWLLMLVSGSWGQ-VNRLPFFTNHFFD-TYLLISEDTPVGSSVTQLLARDMDNDPLVFGVSGEEA 74

  Fly    67 --VFSVDRETGVVRLRQELDRETQDTVEVIISITD-EGIYGTEPNTVSQRRVIPVRDYNDNQPTF 128
              .|:|:.:||||.|||.|||||:....|..|::| :|:       ::::..|.|.|.|||.|||
  Rat    75 SRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGV-------ITRKVNIQVGDVNDNAPTF 132

  Fly   129 LGRPYTASVSESLPVGSELSVEPPIVVV---DRDEGINSEVQMKCLEENDICDIFEVRAVKISDG 190
            ..:||:..:.|:.|||:      ||.:|   |.|.|....|.......:....|...|.:
  Rat   133 HNQPYSVRIPENTPVGT------PIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGI----- 186

  Fly   191 NYTARVALKQQLDFESRPSYILTISASDSALDNRLSSLATISINVIDIQDQPPIFTNAPYSATVP 255
                 |.:.::||:|...:|.||::|:|......||:||.::|.:.|:||..|||.|.|||..:.
  Rat   187 -----VTVIRELDYEVTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIY 246

  Fly   256 ENTPAGVSILTVKAVDGDVGIPREIFLSLEDEPFGHFELVPFGDPRDGTAVLQTTSEPLDRENAE 320
            |::|.|.::..:.|||.|.|.||.|..::..   |:...:...|...|...|...   |||||.
  Rat   247 EHSPPGTTVRVITAVDQDKGRPRGIGYTIVS---GNTNSIFALDYISGALTLNGL---LDRENP- 304

  Fly   321 ILQNGGVYVFSIRATELIDGAIPAEHSLTRV-TIVVTDVDDHQPTFSGPHFNVSITENLANGMPL 384
             |.:.| ::.:::.|||.|...|::.::|.. .|:|.|::|:.|.|:...::|:|||....|..|
  Rat   305 -LYSHG-FILTVKGTELNDDRSPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL 367

  Fly   385 PGLSIFVDDRDMGENSRYELSLRDVFNAARVFEVSPTESQGRTPVVVKVLNASRLDYDVVDPDLR 449
            | |.|.|.|:|.|.||.:|:.|  |.|.:..|.:|||..||:..:.::|  |..|||:.||
  Rat   368 P-LFIQVVDKDEGLNSMFEVYL--VGNNSHHFIISPTSVQGKADIRIRV--AIPLDYETVD---- 423

  Fly   450 KFEFDLVASVKGVEK-AKTRVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSG 513
            :::|||.|:....:. ...:|:|.|::.|||.|:|.|..|..:..||:.|...:..|.|||.|.|
  Rat   424 RYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNVSLYENITVGTSVLTVLATDNDVG 488

  Fly   514 EFGHVRYVLKGFGADNFYVNPETGGVYLLKPLDYEKQSSYSLTVVAIDGGQREANANLFVGVTDV 578
            .||.|.|.... ..|.|.::.:||.:.|:..||||....::|||:|.|||..|....:.:.|.||
  Rat   489 TFGEVNYFFSD-DPDRFSLDKDTGLIMLIARLDYELIQRFTLTVIARDGGGEETTGRVRINVLDV 552

  Fly   579 NDNHPNFESKEYSRTIREGAALFEPQFFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDT 643
            |||.|.|:...|...:||..........:||.|.|.|.  |..:.||||:.::. |:.|.|....
  Rat   553 NDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPP--NNLITYSIVNASAF-GSYFDISVYE 614

  Fly   644 GEIVIQKAARSMDTER---GEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMEN 705
            |..|| ..:|.:|.|:   |...|.|.|.|.|.|||.:|..|.:.|             |...:|
  Rat   615 GYGVI-SVSRPLDYEQIPNGLIYLTVMAKDAGNPPLYSTVPVTIEV-------------FDENDN 665

  Fly   706 LPIIGPPSYRVSIPENAAAGSNVTSVSAHDPD-----GLDSLLRYRIVGANDNFEIDEISGLITV 765
            .|....|:|.||:.||..||:.|..::|.|.|     |.:|:: |.:.|:: .|.|:..||.||.
  Rat   666 PPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-YSLEGSS-QFRINARSGEITT 728

  Fly   766 SPQARIDRDSNMNSFEIIVNAVDSGT-PIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTA 829
            :  :.:||::.. .:.:||.|||.|. ...:|...||.|.:.||||..|.::...|...:.|.|.
  Rat   729 T--SLLDRETKA-EYILIVRAVDGGVGHNQKTGIATVNVTLLDINDNHPTWKDAPYYINLVEMTP 790

  Fly   830 VGESVLRVKAIDKDL--NSKLEYSMVGP------------------------------------- 855
            ....|..|.|:|.||  |..|.||:..|
  Rat   791 PDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHVMLDRENPDPVEAELMRKII 855

  Fly   856 VAAT-----------------------------------------TKAGVSIANRSNYRLQEAFR 879
            |:.|                                         |.||||:        .:...
  Rat   856 VSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGTPAGVSV--------YQVVA 912

  Fly   880 VDSQSGEIFVNGTLRHDVAA-------IIIFTVGVRDLNAEVDPE-----------------GQV 920
            :|...|   :||.:.:.:..       :|..|.||....||:|.|                 .:.
  Rat   913 IDLDEG---LNGLVSYRMQVGMPRMDFVINSTSGVVTTTAELDRERIAEYQLRVVASDAGTPTKS 974

  Fly   921 DTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQAEDPVTRQPITSFELI 985
            .|:.:|:.|....|..|.|       ...|.:|.:.|::|.:..:..|...|............|
  Rat   975 STSTLTIRVLDVNDETPTF-------FPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI 1032

  Fly   986 EPKQVD-YFQVAERTGEVILKKRLDYEALG---------DTGPEFELQVRANSADRQRSTVSRVN 1040
            ....|| .|.|..|...|.....||.|...         |.||          ..::|:..:.|.
  Rat  1033 TAGNVDGKFSVGYRDAVVRTVVGLDRETTAAYTLVLEAIDNGP----------VGKRRTGTATVF 1087

  Fly  1041 ITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLG--YHKIIYSLQGE 1103
            :||.:||||.|.|.::||:|::.|:.|....:::::|.|.|      :...|  :::|   |.|.
  Rat  1088 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSIVQLKATDAD------EGEFGRVWYRI---LHGN 1143

  Fly  1104 HAMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAP 1168
            |...|.::.::| ::|...:.:||||.....|..:|.:....|   .:|.|.:.:.|.||||.||
  Rat  1144 HGNNFRLHVSSG-LLVRGPRPLDRERNSSHVLMAEAYNHDLGP---MRSSVRVIVYVEDVNDEAP 1204

  Fly  1169 EFTQKKYSTV-IPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRR 1232
            .|||::|:.: :.|.|.|.:.|:.:.|.|.|.|.||.|.|.:::..|  |.|:||..:|||.|..
  Rat  1205 VFTQQQYNRLGLRETAGIGTSVIVVRATDRDTGDGGLVNYRILSGAE--GKFEIDESTGLIVTVD 1267

  Fly  1233 NLTGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYF------------- 1284
            .|                          ...|.|.   |:.:|||.||.|.|
  Rat  1268 YL--------------------------DYETKTS---YLMNVSATDGAPPFNQGFCSVYVTLLN 1303

  Fly  1285 -LSPRVGQMAN------VTENAVTGAPVFQVIASDPDDESTPSGTITYRILPDTPDAEA---FVI 1339
             |...| |.:|      :.||...|..:.:|.|...|:    ...||||....| .|:|   |.|
  Rat  1304 ELDEAV-QFSNASYEAVIMENLALGTEIVRVQAYSIDN----LNQITYRFDAYT-SAQAKALFKI 1362

  Fly  1340 DAHSGLITTRQSMDRETKDMYRILLEVSDNGQPKQSATRILQIAILDVDDHEPRFAREADAGPLS 1404
            ||.:|:||.:..:|||..|.|.:.: |:|:|.||..:| ::.:.:||.:|:.|||...:|:   :
  Rat  1363 DAITGVITVKGLVDREKGDFYTLTV-VADDGGPKVDST-VVYVTVLDENDNSPRFDFTSDS---A 1422

  Fly  1405 MSVREEEPAGTIVGNFSALDEDLGENAAIDYVIIDGNNEQLFTIERNNESLAILKTKKPIDREQV 1469
            :||.|:.|.|..|....|.|.|.|.|..:.:.:..||....|.|..:|:|:..:...||:|||::
  Rat  1423 ISVPEDCPVGQRVATVKARDPDAGSNGQVVFSLASGNIAGAFEIITSNDSIGEVFVAKPLDREEL 1487

  Fly  1470 ESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVLDIDDNLPKFEQP-DPTVGIRINVPID 1533
            :.:.|.|.....|.|..|          ..|: :.|.:||::||.|..|.| ...|.:..||...
  Rat  1488 DHYILKIVASDRGTPPRK----------KDHI-LQVTILDVNDNPPVIESPFGYNVSVNENVGGG 1541

  Fly  1534 TVVTTLKASDADAEAPPVGLSIENVTFVPQFYKRSRSLAVGNLHNLFTLNNRTGELRTGGSFADY 1598
            |.|..::|:|.|     :|     :..|..:|     :..||....|.::..:||:.|..:..|.
  Rat  1542 TSVVQVRATDRD-----IG-----INSVLSYY-----ITEGNEDMTFRMDRISGEIATRPAPPDR 1591

  Fly  1599 V-DGYFLMRVMANNSVQPKRQAHSNLKVFVIRDKSLLKFVFARPPNEI 1645
            . ..::.:.|...:...|...|.:::.|.:: |::....||.:|..|:
  Rat  1592 ERQNFYHLVVTVEDEGTPTLSATTHVYVTIV-DENDNAPVFQQPHYEV 1638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cad74A	NP_648973.1	Cadherin_repeat	33..124	CDD:206637	36/95 (38%)
		Cadherin_repeat	132..240	CDD:206637	30/110 (27%)
		Cadherin_repeat	249..361	CDD:206637	34/112 (30%)
		Cadherin_repeat	487..581	CDD:206637	35/93 (38%)
		Cadherin_repeat	589..686	CDD:206637	33/99 (33%)
		Cadherin_repeat	713..810	CDD:206637	35/102 (34%)
		Cadherin_repeat	819..936	CDD:206637	37/220 (17%)
		Cadherin_repeat	953..1049	CDD:206637	24/105 (23%)
		Cadherin_repeat	1057..1166	CDD:206637	29/110 (26%)
		Cadherin_repeat	1175..1279	CDD:206637	29/104 (28%)
		Cadherin_repeat	1293..1390	CDD:206637	34/105 (32%)
		Cadherin_repeat	1402..1513	CDD:206637	31/110 (28%)
		Cadherin_repeat	1523..1628	CDD:206637	22/105 (21%)
Cdh23	XP_063134984.1	None