DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and Cdh22

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:NP_778153.2 Gene:Cdh22 / 104010 MGIID:1341843 Length:813 Species:Mus musculus


Alignment Length:536 Identity:152/536 - (28%)
Similarity:240/536 - (44%) Gaps:55/536 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   993 FQVAERTGEVILKKRLDYEALGDTGPEFELQVRANSADRQRSTVSRVNITVENVNDNSPRFERNS 1057
            |.:.|.||::...:|||.|.  .|......|.|..:.:|.....|...|.|:::||:.|||....
Mouse   107 FLIDELTGDIHATERLDREQ--KTFYTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGP 169

  Fly  1058 YQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYS-LQGEHAMLFDINNTTGEIIVAS 1121
            |..::.|..|....|::|.|.|.|........||     :|| |.|||.  |.::..|| :|..:
Mouse   170 YIGSVAELSPTGTSVMQVMASDADDPTYGSSARL-----VYSVLDGEHH--FTVDPKTG-VIRTA 226

  Fly  1122 GQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPEFTQKKYSTVIPENAQID 1186
            ...:|||...|.::.|:|.|..|:......|.. :.|.|.|||||.|.|.||.|...|.|:|.|.
Mouse   227 VPDLDRESQERYEVVIQATDMAGQLGGLSGSTT-VTIVVTDVNDNPPRFPQKMYQFSIQESAPIG 290

  Fly  1187 SFVLQLEAVDADEGLGGEVRYELVNE-GEANGLFKI----DTKSGLISTRRNLTGKG-RAHPYVL 1245
            :.|.:::|.|:|.|...::.|.|..| |.....||:    ||:..:|..:::|..:. :.|..||
Mouse   291 TAVGRVKAEDSDVGENTDMTYHLREESGSGGDAFKVTTDSDTQEAIIVVQKHLDFESQQVHTVVL 355

  Fly  1246 --IVRAQDNGNQMPKQPTLSTDTD---VRIYIGDVSANDGVPYFLSPRVGQMANVTENAVTGAPV 1305
              :.:..|     |:...|.|..|   ||:.:.||   |..|.|..|  ..:..|.|:|..|:.|
Mouse   356 EALNKFVD-----PRFADLGTFRDQAIVRVAVTDV---DEPPEFRPP--SGLLEVQEDAQVGSLV 410

  Fly  1306 FQVIASDPDDESTPSGTITYRILPDTPDAEAFVIDAHSGLITTRQSMDRETKDMYRILLEVSDNG 1370
            ..|.|.|||..:.|   :.|.|..|:...:.|.|||.:|.|.|.:.:||||...:.|.:...:..
Mouse   411 GVVTARDPDAANRP---VRYAIDRDSDLEQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEAD 472

  Fly  1371 QPKQSATRILQIAILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLGENAAIDY 1435
            ...|.:...|:|.||||:|:.|..|.     |...:|.|:...|.::...|.:|.|..:.....|
Mouse   473 NHAQLSRASLRIRILDVNDNPPELAT-----PYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFY 532

  Fly  1436 --VIIDGNNEQLFTIERNNESLAILKTKK-PIDREQVESFTLTIKCLKLGEPGYKFIGDPYDRQD 1497
              ::.:..:...|::....::.|.:.|:. ..:|::.:.|.|.|..:..|.|.....|       
Mouse   533 FRLVPEAPSNPHFSLLDIEDNTAAVHTQHVGFNRQEQDVFLLPILVVDSGPPTLSSTG------- 590

  Fly  1498 LSHLRINVRVLDIDDN 1513
                .:.:|:...|.:
Mouse   591 ----TLTIRICGCDSS 602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637
Cadherin_repeat 132..240 CDD:206637
Cadherin_repeat 249..361 CDD:206637
Cadherin_repeat 487..581 CDD:206637
Cadherin_repeat 589..686 CDD:206637
Cadherin_repeat 713..810 CDD:206637
Cadherin_repeat 819..936 CDD:206637
Cadherin_repeat 953..1049 CDD:206637 16/55 (29%)
Cadherin_repeat 1057..1166 CDD:206637 34/109 (31%)
Cadherin_repeat 1175..1279 CDD:206637 32/114 (28%)
Cadherin_repeat 1293..1390 CDD:206637 33/96 (34%)
Cadherin_repeat 1402..1513 CDD:206637 20/113 (18%)
Cadherin_repeat 1523..1628 CDD:206637
Cdh22NP_778153.2 Cadherin_repeat 80..160 CDD:206637 15/54 (28%)
Cadherin_repeat 169..270 CDD:206637 34/109 (31%)
Cadherin_repeat 279..387 CDD:206637 32/115 (28%)
Cadherin_repeat 398..492 CDD:206637 33/96 (34%)
Cadherin_repeat 499..597 CDD:206637 19/108 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 696..726
CADH_Y-type_LIR 743..802 CDD:460041
Blue background indicates that the domain is not in the aligned region.

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