DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and dchs1a

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:XP_002664697.2 Gene:dchs1a / 100334632 ZFINID:ZDB-GENE-120410-3 Length:3275 Species:Danio rerio


Alignment Length:2136 Identity:514/2136 - (24%)
Similarity:814/2136 - (38%) Gaps:581/2136 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 PLFLSLTAGQLVNQPPQFVPGTGDMSRFSLSENTPVGSPVFQLKGTDPEGG----------RLKY 61
            |:|.|||                  .|..|.|:||:.:...|::..:.:||          .|.|
Zfish   994 PVFDSLT------------------YRVELKESTPLNTRFLQVRAVNRDGGITTGLSSTSASLAY 1040

  Fly    62 SI----SGPVFSVDRETGVVRLRQELDRETQDTVEVIISITDEGIYGTEPNTVSQRRVIPVRDYN 122
            .:    ....|.:..::|.:.::..||||.::...:.:..|...  |....|.|....:.|.|.|
Zfish  1041 HLHPDGDAAGFGIVSDSGWLFVKSALDREAKEMYLLTVLATSGN--GQLKKTGSATVRVSVMDEN 1103

  Fly   123 DNQPTFLGRPYTASVSESLPVGSELSVEPPIVVVDRDEGINSEVQMKCLEENDICDIFEVRAVKI 187
            ||.|.|.......:|.|:||.|:...   .:...|||.|:|..:..:.|..:        |..:|
Zfish  1104 DNTPRFTQERAFLAVRENLPAGTGFG---RVSASDRDAGLNGRLSYRLLHLD--------RHFQI 1157

  Fly   188 SDGNYTARVALKQQLDFESRPSYILTISASDSALDNRLSSLATISINVIDIQDQPPIFTNAPYSA 252
            :  ::|..::.|..||.|.:.||.|.:.|.|.....| |:..|..|.|:|..|..|.|:||....
Zfish  1158 N--SHTGEISTKLSLDRELQSSYQLIVVAQDGGTPPR-SATGTAFITVLDENDNAPSFSNAQTGR 1219

  Fly   253 TV----PENTPAGVSILTVKAVDGDVGIPREIFLSLEDEPFGHFELVP-FGDPRDGTAVL----- 307
            .:    .|..|:|..:.||.|.|.|.|....||.|:.......|.|.| .|:.|..:|:.     
Zfish  1220 ELLLQALEGQPSGFLLGTVHAKDPDEGENGTIFYSMSGPRAERFTLNPNTGELRSSSALSHSERP 1284

  Fly   308 ----------------------------------QTTSEPLDRENAE-----------------I 321
                                              .|.|:||..::.|                 .
Zfish  1285 EYSFIILASDRGSPPQSSIIALKIQVLSSSKGSPNTNSQPLILKSVEGAKPGSMIGSVRSPDSQA 1349

  Fly   322 LQNGGVYVFSI-------------RAT---------------------ELIDGAIPAEHS-LTRV 351
            |...|...|::             |.|                     |:.|.::|...| :..:
Zfish  1350 LPESGQVTFTVVGGTDFDGTFVVDRQTGDIYLARELDFEKCPRYTLQVEVDDFSMPLPKSDIITL 1414

  Fly   352 TIVVTDVDDHQPTFSGPHFNVSITENLANGMPLPGLSIF----VDDRDMGENSRYELSLRDVF-N 411
            .|.|.|.:||.|.|......:.:.||..     ||.|.:    ||....|.||....|:...: |
Zfish  1415 IIDVQDSNDHSPEFPEDPIIIVVPENTD-----PGSSFYTFQAVDKDGSGPNSEVHYSILQQWPN 1474

  Fly   412 AARVFEVSPTE---SQG------RTPVVVKVLNASRLDYDVVDPDLRKFEFDLVASVKGVEKAKT 467
            ...:..:.||.   |.|      :|..::.|:.||                |....|....:...
Zfish  1475 IPDLLSLDPTTGALSLGMMLDHEKTSSLLLVVQAS----------------DSALDVSQRRRGSV 1523

  Fly   468 RVEIHLLDANDNAPVFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRY-VLKGFGADNFY 531
            ...|.:.|.|||.|||...:. .:..|:.||..::.:|.|.|.|.||.|.|.| :..|.....|.
Zfish  1524 TARIFVTDVNDNEPVFISASV-VSVMEDQPVGFVVVYVMAVDADQGENGRVTYRIQSGNVRGKFS 1587

  Fly   532 VNPETGGVYLLKPLDYEKQSSYSLTVVAIDGG--QREANANLFVGVTDVNDNHPNFESKEYSRTI 594
            :||:||.:.:|:|:|.|::..|:||:||.|.|  ||.::..|.|.|.||||..|.|:..:|...|
Zfish  1588 INPDTGSLSILRPIDREEEDLYNLTIVAEDHGLQQRSSSQLLSVQVIDVNDEAPYFQESQYEAFI 1652

  Fly   595 REGAALFEPQFFVRAHDADGPSQG-NGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTE 658
            .|..........|.|.|.|   || ||     ||:..||.|:.|.|.|.||.|...||   :|.|
Zfish  1653 AENQPAGSTVLVVSASDMD---QGTNG-----IVTYGSIVGDDFSIHPVTGVITTTKA---LDRE 1706

  Fly   659 -RGEYELVVSATDFGIPPLSNTTRVLVRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENA 722
             :|.|.|.|.|.|.|.||  |..:..|||.:           ....:|.|..|...|.:.:|||.
Zfish  1707 AQGVYALTVYARDGGSPP--NFAKTTVRVTV-----------LDENDNRPAFGRVYYSLEVPENQ 1758

  Fly   723 AAGSNVTSVSAHDPDGLDS-LLRYRIVGAN--DNFEIDEISGLITVSPQARIDRDSNMNSFEIIV 784
            ...:..| :.|.|.|..|| |:.|||...:  .:|.:|:..|:::.|  ..:||:|.. .:.:.|
Zfish  1759 EPVTLFT-IRATDQDSGDSGLVYYRITDGDHFGDFHLDKKLGVLSTS--RALDRESRA-KYTLTV 1819

  Fly   785 NAVDSGTPIPETATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKD--LNSK 847
            .|.|.|.| ..|:|.|:.::|.|:||..|.|..:||:..|||..:.|..||.|.|.|||  .||:
Zfish  1820 EAQDQGIP-SLTSTVTLDISVLDLNDNSPVFPSSSYSVEVSEDASAGSLVLEVSASDKDEGSNSQ 1883

  Fly   848 LEY------------------------------------------SMVGPVAATTKA-------- 862
            :.|                                          |...|..::.:.        
Zfish  1884 VVYFLSRESSGMFIVDQHTGRIITAATLDREKVASYNFQVYAMDSSATNPRNSSAEVAVHILDVN 1948

  Fly   863 -------------GVSIANRSNYRLQEAFRVDSQ----SGEIF------VNGTLRHDVAAII--- 901
                         .|||::.||:|:....|.:.:    :|.:|      |.|...:.:...|   
Zfish  1949 DNAPFFITDPLIINVSISSLSNHRVLATMRAEDKDFGANGSVFYRFANPVKGFTINSLTGAIQAT 2013

  Fly   902 ----IFTVGVRDLNAEVDPEG---QVDTTEVTVYV--QSFQDTNPVFKNTGWTSSRPVIDVKIKE 957
                ..|...|.|..|...:|   |.....|.||:  ||:|         |...||...||.::|
Zfish  2014 EKLQALTQSQRILIVEAMDQGNPSQSSLGVVIVYIREQSYQ---------GVRFSRNTRDVSLQE 2069

  Fly   958 EMPIDSALFILQAEDPVTRQPITSFELIEPKQVDYFQVAERTGEVILKKR--LDYEALGDTGPEF 1020
            .....:|:..:.|:.|.......::.:....:...|.::..|||:.::..  ||:|..    |..
Zfish  2070 NAAKGTAVVQIHAQYPDGSTSGINYSIFSGNKQQSFSISHHTGEIWVEDSTGLDFEET----PRL 2130

  Fly  1021 ELQVRANSADRQRSTVSRVNITVENVNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLN 1085
            .|.|:|.:|  ..|:...||:.:::||||.|||:.::|.|.:.|.:.:...:|:|.|.|.|...|
Zfish  2131 RLVVKAETA--SSSSFMAVNLLLQDVNDNLPRFQLHNYVAYVREAQGYDHPIIQVLANDLDQGQN 2193

  Fly  1086 ARDERLGYHKIIYSLQGEH-AMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAED-------- 1141
            .        ::.||::... :.||.|:..||.|..|:  .:|||...:..|.|.|.|        
Zfish  2194 G--------QVTYSIRSSSMSGLFKIDPITGSISTAA--IMDREIWTQTNLVIMATDRGSPRLAG 2248

  Fly  1142 --------------SPGRP---------------------------------------------- 1146
                          ||..|                                              
Zfish  2249 SATLTVIIVDLNDNSPTIPVPREVRVPENTLIGTMITQVTGNDVDSGPALSYTLLLDSDTQGKFG 2313

  Fly  1147 ----------------------------TDAK-QSVVELQIEVLDVNDNAPEFTQKKYSTVIPEN 1182
                                        :|:| ||...|.|.|.|||||||.|:|..|...:.|:
Zfish  2314 IHRYGGGVSLTTPLDFEIKTWYTLTVSSSDSKQQSHANLTILVEDVNDNAPVFSQDLYEVTLAEH 2378

  Fly  1183 AQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNLTGKGRAHPYVLIV 1247
            :...|.|:.:.|.|.|.|..|.:.|.:|:   ...:|.||..:|.:..::.:....:....::::
Zfish  2379 SPAGSSVITVTATDKDSGENGRITYRVVS---TKDMFYIDPSNGTLFIKKEVEFDSQRPSILVVI 2440

  Fly  1248 RAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPYFLSPRVGQMANVTENAVTGAPVFQVIASD 1312
            .|.|:|.     |.|:..:.|::::.||  ||..|.|  .:....|:|:|:.|.|:.:..:.|:|
Zfish  2441 EASDSGT-----PPLTALSTVQVHVSDV--NDNAPVF--HQTEYRASVSEDEVPGSTILTLEAAD 2496

  Fly  1313 PD--------DESTPSGTI--TYRILPDTPDAEAFVIDAHS----GLITTRQSMDRETKDMYRIL 1363
            .|        |.:..||.|  |::|     ::....::.|.    |::.....:|.|....|.:.
Zfish  2497 GDLSRDNCGFDFAIASGNIGNTFQI-----ESSVRFLEGHGFQTVGMLILADKLDFEIASSYNLT 2556

  Fly  1364 LEVSDNGQPKQSATRILQIAILDVDDHEPRFAREADAGPLSMSVREEEPAGTIVGNFSALDEDLG 1428
            :.|||.|.|::|::..:.|.::|.:|:.|.|:|    ...|..|.|....||.:....|:|.|..
Zfish  2557 IVVSDRGIPQRSSSVPVLINVMDTNDNPPSFSR----AEYSAVVNEGAERGTEILQLFAIDPDST 2617

  Fly  1429 ENAAIDYVIIDGNNEQLFTIERNNESLAILKTKKPIDREQVESFTLTIKCLKLGEPGYKFIGDPY 1493
            .|..:.|.|..|::.:|||::   :....::.::.:|.|:..|              :.|:....
Zfish  2618 PNGEVQYSISSGDDSELFTVD---QWTGAVRLRRSLDSEKQSS--------------HMFVIQAS 2665

  Fly  1494 DRQDLSHLR---INVRVLDIDDNLPKFEQPDPTVGIRINVPIDTVVTTLKASDADAEAPPVGLSI 1555
            |.|  .|..   :.|.:.||::|.|.|.....|..||.|.|.:.:||.|.|.|.|..|       
Zfish  2666 DGQ--GHFALAPVTVEIKDINNNRPYFPLKSLTASIRENQPQNALVTILHAIDHDKGA------- 2721

  Fly  1556 ENVTFVPQFYKRSR---SLAVGNLHNLFTLNNRTGELRTGGSFADY----VDGYFLMRVMANNSV 1613
                     |...|   :...||..:.|.:|..:||:||..:| ||    ...:..:.:...|..
Zfish  2722 ---------YGELRYFLTYNAGNGKDSFLVNQTSGEVRTRFTF-DYEKTNTFNFIAIAMDTGNYT 2776

  Fly  1614 QPKRQAHSNLKVFVIRDKSL------LKFVFARPPNEIQ------------------------HN 1648
                 |...::|||..:...      ..|.|..|....:                        .|
Zfish  2777 -----ATVTVQVFVTGEDEYDPVFTESDFAFHVPEGAKKGQSIGQVNANDEDGGVDGIVLYTLAN 2836

  Fly  1649 IRPFQEQLQKKLKPLGLEL-----HVLDTQVFTRPDMSLDFTATSSCFQMFKNGAALSFNEMQKL 1708
            ..|:.| |......:.|::     ||..::..|| .|:||..|.|                  .|
Zfish  2837 SSPYFE-LNTSTGVISLKMDAYHRHVTRSKRETR-QMTLDVIAHS------------------PL 2881

  Fly  1709 MNSQQLRQEL-IDI-YAAYGVSEVESCSVRRTHAAAIFAGMLTSAGAWLVFLAALI 1762
            .||::...:: :|: :.::|::         |....:.|..:|::.|.:|||..::
Zfish  2882 ENSRKTSAQITVDVTHTSFGLT---------TDMNVVLASAITASLAAIVFLIIVV 2928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637 23/104 (22%)
Cadherin_repeat 132..240 CDD:206637 29/107 (27%)
Cadherin_repeat 249..361 CDD:206637 35/207 (17%)
Cadherin_repeat 487..581 CDD:206637 37/96 (39%)
Cadherin_repeat 589..686 CDD:206637 37/98 (38%)
Cadherin_repeat 713..810 CDD:206637 31/99 (31%)
Cadherin_repeat 819..936 CDD:206637 42/203 (21%)
Cadherin_repeat 953..1049 CDD:206637 22/97 (23%)
Cadherin_repeat 1057..1166 CDD:206637 38/206 (18%)
Cadherin_repeat 1175..1279 CDD:206637 23/103 (22%)
Cadherin_repeat 1293..1390 CDD:206637 27/110 (25%)
Cadherin_repeat 1402..1513 CDD:206637 25/113 (22%)
Cadherin_repeat 1523..1628 CDD:206637 29/111 (26%)
dchs1aXP_002664697.2 Cadherin_repeat 45..135 CDD:206637
Cadherin_repeat 145..247 CDD:206637
Cadherin_repeat 256..354 CDD:206637
Cadherin_repeat 370..464 CDD:206637
Cadherin_repeat 472..571 CDD:206637
Cadherin_repeat 580..678 CDD:206637
Cadherin_repeat 686..778 CDD:206637
Cadherin_repeat 791..886 CDD:206637
Cadherin_repeat 900..990 CDD:206637
Cadherin_repeat 1000..1105 CDD:206637 24/124 (19%)
Cadherin_repeat 1118..1208 CDD:206637 29/103 (28%)
Cadherin_repeat 1227..1311 CDD:206637 18/83 (22%)
Cadherin_repeat 1331..1424 CDD:206637 13/92 (14%)
Cadherin_repeat 1432..1535 CDD:206637 25/123 (20%)
Cadherin_repeat 1544..1638 CDD:206637 36/94 (38%)
Cadherin_repeat 1647..1741 CDD:206637 39/117 (33%)
Cadherin_repeat 1750..1845 CDD:206637 32/99 (32%)
Cadherin_repeat 1861..1950 CDD:206637 13/88 (15%)
Cadherin_repeat 1958..2048 CDD:206637 20/89 (22%)
Cadherin_repeat 2065..2157 CDD:206637 22/97 (23%)
Cadherin_repeat 2166..2262 CDD:206637 25/105 (24%)
Cadherin_repeat 2269..2362 CDD:206637 10/92 (11%)
Cadherin_repeat 2371..2466 CDD:206637 24/104 (23%)
Cadherin_repeat 2474..2583 CDD:206637 27/113 (24%)
Cadherin_repeat 2591..2686 CDD:206637 25/113 (22%)
Cadherin_repeat 2694..2790 CDD:206637 30/117 (26%)
Cadherin_repeat 2802..2896 CDD:206637 20/113 (18%)
Blue background indicates that the domain is not in the aligned region.

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