DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad74A and cdh19

DIOPT Version :10

Sequence 1:NP_648973.1 Gene:Cad74A / 39936 FlyBaseID:FBgn0036715 Length:1820 Species:Drosophila melanogaster
Sequence 2:XP_073797385.1 Gene:cdh19 / 100332418 ZFINID:ZDB-GENE-130530-766 Length:799 Species:Danio rerio


Alignment Length:600 Identity:159/600 - (26%)
Similarity:257/600 - (42%) Gaps:80/600 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 NDNQPTFLGRPYTASVSESLPVGSELSVE-----PPIVVVDRDEGINSEVQMKCLEENDICDIFE 181
            ::.|...|.||.:.        ||.|.|.     ..|.|.:.|....:..|:|  .:.|..| |.
Zfish    27 SEQQQEKLFRPESR--------GSHLRVRRGWIWSQIFVEEEDSTPRNIGQLK--SDYDSGD-FT 80

  Fly   182 VRAVKISDG--------NYTARVALKQQLDFESRPSYILTISASDSALDNRLSSLATISINVIDI 238
            ::.:...:|        .||..::..|.||.|.:|.|.|...|.:......:...:...|.|.||
Zfish    81 IKYILSGEGAGEIFIIDEYTGEISSLQPLDREVKPYYTLQAQAINRRSKQPVEPESEFIIKVQDI 145

  Fly   239 QDQPPIFTNAPYSATVPENTPAGVSILTVKAVDGDVGI----PREIFLSLEDEPFGHFELVPFGD 299
            .|..|.|.|.||.:::||..|.|.:::.|.|.|.|..:    .:.|:..|:.||:  |.:.|   
Zfish   146 NDNAPEFINEPYVSSIPEMCPTGTTVIQVTATDADDPMFGNNAKLIYSILQGEPY--FSVEP--- 205

  Fly   300 PRDGTAVLQTTSEPLDRENAEILQNGGVYVFSIRATELIDGAIPAEHSLTRVTIVVTDVDDHQPT 364
               .|.::.|:...||||..||      |:..::..::: |......:.|.|||.:|||:|:.||
Zfish   206 ---TTGIIVTSWSQLDREAKEI------YLVVVQVKDML-GLSGGFSATTTVTISLTDVNDNGPT 260

  Fly   365 FSGPHFNVSITENLANGMPLPGLSIFVDDRDMGENSRYELSLRDVFNAAR-VFEVSPTESQGRTP 428
            |....:..:::|:...|..:.  .|..:|.|:|.|:|...||.|:..::. .....|...:|   
Zfish   261 FQHNLYTFAVSESAPVGSTVG--RIMAEDGDVGVNARMNYSLEDLEESSTFTIHTDPETQEG--- 320

  Fly   429 VVVKVLNASRLDYDVVDPDLRKFEFDLVASVKGV-----------EKAKTRVEIHLLDAN-DNAP 481
               .::.|..|||:    :.|:|    |.:|:.:           ::...|..:.:...| |..|
Zfish   321 ---IIILAQPLDYE----NKRRF----VIAVEAINENTDTRFLSMDQFSDRTTLKITVTNVDEPP 374

  Fly   482 VFDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRYVLKGF--GADNFYVNPETGGVYLLKP 544
            ||....|.:...||......:|.|.|.|.|..... :||.|...  ....|.::|:.|.||:...
Zfish   375 VFSGTPYIWKVLENAQTSTQVGTVYARDTDITNTA-IRYDLSETPDTQQMFRIDPDNGTVYVTNL 438

  Fly   545 LDYEKQSSYSLTVVA--IDGGQREANANLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQFFV 607
            ||.|..:.|:|||.|  |...|..::.::.:.|.|:|||.|.. :.:|...:.|.|...|....:
Zfish   439 LDRETAAWYNLTVFAREILDNQLSSSVSVLITVLDINDNPPAL-AHDYQPFVCEDAQPGELIELI 502

  Fly   608 RAHDADGPSQGNGRVKYSIVSENSIAGN-VFRIEPDTGEIVIQKAARSMDTERGEYELVVSATDF 671
            .|.|||.|..|. ...:|::.:..|..| ..|...|....|:.:.:.....|:..|.|.|...|.
Zfish   503 SATDADDPVDGQ-HFYFSMIPDKHINPNFTIRDNQDNTASVLARRSSFRRQEQTHYHLPVVIRDS 566

  Fly   672 GIPPLSNTTRVLVRV 686
            |.|.||:|:.:.:||
Zfish   567 GTPVLSSTSTLSIRV 581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad74ANP_648973.1 Cadherin_repeat 33..124 CDD:206637 0/1 (0%)
Cadherin_repeat 132..240 CDD:206637 28/120 (23%)
Cadherin_repeat 249..361 CDD:206637 33/115 (29%)
Cadherin_repeat 487..581 CDD:206637 29/97 (30%)
Cadherin_repeat 589..686 CDD:206637 26/97 (27%)
Cadherin_repeat 713..810 CDD:206637
Cadherin_repeat 819..936 CDD:206637
Cadherin_repeat 953..1049 CDD:206637
Cadherin_repeat 1057..1166 CDD:206637
Cadherin_repeat 1175..1279 CDD:206637
Cadherin_repeat 1293..1390 CDD:206637
Cadherin_repeat 1402..1513 CDD:206637
Cadherin_repeat 1523..1628 CDD:206637
cdh19XP_073797385.1 None
Blue background indicates that the domain is not in the aligned region.

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