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Protein Alignment Cad74A and celsr3

DIOPT Version :10

Sequence 1:	NP_648973.1	Gene:	Cad74A / 39936	FlyBaseID:	FBgn0036715	Length:	1820	Species:	Drosophila melanogaster
Sequence 2:	XP_009302289.1	Gene:	celsr3 / 100008568	ZFINID:	ZDB-GENE-070122-3	Length:	3666	Species:	Danio rerio

Alignment Length:	1234	Identity:	339/1234 - (27%)
Similarity:	545/1234 - (44%)	Gaps:	201/1234 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 DHQPTFSGPHFNVSITENLANGMPLPGLSIF---VDDRDMGENSRYELSLRDVFNAARV--FEVS 419
            :.||.|...::.|.:.||    .| ||.|:.   .:|.|.||..|...|:..:.|:..:  |::.
Zfish   705 NRQPQFPQYNYQVQVAEN----QP-PGTSVIAMTAEDHDAGEAGRLSYSMAPLMNSRSMDYFQID 764

  Fly   420 PTESQGRTPVVVKVLNASRLDYDVVDPDLRKFEFDLVASVKGVE--KAKTRVEIHLLDANDNAPV 482
            |......|   ..:|:...:|...         |.:.|:..|..  ...|.|.|.:.|.||::||
Zfish   765 PITGLLTT---THILDREHMDLHY---------FRVTAADHGSPHLSGTTMVTITVADRNDHSPV 817

  Fly   483 FDQGTYRFTAAENLPVDAIIGHVKATDLDSGEFGHVRYVLKGFGA----DNFYVNPETGGVYLLK 543
            |:|..||.|..||:.....|..::||||||....::||...|..|    ..|.::|.:|.:....
Zfish   818 FEQTEYRETIRENVEEGYPILQLRATDLDSTANANIRYRFVGESAAVARSAFEIDPRSGLITTRG 882

  Fly   544 PLDYEKQSSYSLTVVAIDGGQ----REANANLFVGVTDVNDNHPNFESKEYSRTIREGAALFEPQ 604
            .:|.|....|:|.|.|.|.|:    |.|..::.:.|.|.|||.|.|..|.|...:||........
Zfish   883 IVDRETNERYTLLVEASDQGREPGPRSATVSVHITVLDENDNVPQFSQKRYVVAVREDVRPHSEI 947

  Fly   605 FFVRAHDADGPSQGNGRVKYSIVSENSIAGNVFRIEPDTGEIVIQKAARSMDTERGEYELVVSAT 669
            ..:.|.|.|  ..||..|.|:|:|.||  ...|.|:..||||.: .|....:||| ||.|.:.|.
Zfish   948 LRISATDQD--KDGNAAVHYNIISGNS--RGQFAIDSVTGEIQV-VAPLDFETER-EYTLRLRAQ 1006

  Fly   670 DFGIPPLSNTTRVL-VRVGISGNQRPIFRGHFQNMENLPIIGPPSYRVSIPENAAAGSNVTSVSA 733
            |.|.|||||.|.:: |:|....:..|||            :..| ::.::.|:|..|.::..:.|
Zfish  1007 DNGRPPLSNNTGIVSVQVTDVNDNPPIF------------VSTP-FQATVLESAPIGHSILHIQA 1058

  Fly   734 HDPD-GLDSLLRYRIVGANDN--FEIDEISGLITVSPQARIDRDSNMNSFEIIVNAVDSGTPIPE 795
            .|.| |.::.|.||:.|...:  |.|:..:|.:|||  :.:||:| :..:...|.|.|.|:| |.
Zfish  1059 IDTDNGDNARLEYRLTGTGTDTPFVINAATGWVTVS--SELDRES-VEHYFFGVEARDYGSP-PL 1119

  Fly   796 TATTTVYVNVKDINDERPKFEQNSYATYVSERTAVGESVLRVKAIDKDLNSKLEYSMVG-----P 855
            :||.:|.:.|.|:||.||:|.|..|...::|..|||.||:.|.|:|:|:||.:.|.:.|     .
Zfish  1120 SATASVTITVMDVNDNRPEFLQKEYYVRLNEDAAVGTSVVSVTAVDRDVNSAVTYQITGGNTRNR 1184

  Fly   856 VAATTKAG---VSIANRSNYRLQEAFRVDSQSGEIFVNGTLRHDVAAIIIFTVGVRDLNAEVDPE 917
            .|.:|..|   ||:|...:|:.:..:                     ::..|...|.|:
Zfish  1185 FAISTAGGAGLVSLALPLDYKQERRY---------------------VLTVTASDRTLH------ 1222

  Fly   918 GQVDTTEVTVYVQSFQDTNPVFKNTGWTSSRPVIDVKIKEEMPIDSALFILQA-EDPVTRQPITS 981
               ||.:|.:.:.......|||::..::       |.:.|:.|..|.:.::.| :|.|......:
Zfish  1223 ---DTCQVHINITDANTHRPVFQSAHYS-------VSVNEDRPPGSTVVVISATDDDVGENARIT 1277

  Fly   982 FELIEPKQVDYFQVAERTGEVILKKRLDYEALGDTGPEFELQVRA-NSADRQRSTVSRVNITVEN 1045
            :.|.:  .:..|::...:|.:.|:..||||    ....:.|.:.| ::...|:|..:.|.:.|.:
Zfish  1278 YYLED--NIPQFRIDPASGAITLQAELDYE----DQMTYTLAITARDNGIPQKSDTTYVEVNVND 1336

  Fly  1046 VNDNSPRFERNSYQATIIENRPHPERVIRVRALDKDAVLNARDERLGYHKIIYSLQ------GEH 1104
            ||||:|:|....||..:.|:.|....|:::.|.|:||..|.|        :.|:.|      |:
Zfish  1337 VNDNAPQFLSPRYQGGVSEDAPPFTSVLQISATDRDAHANGR--------VQYTFQNGEDGDGD- 1392

  Fly  1105 AMLFDINNTTGEIIVASGQTIDRERTPRIQLQIKAEDSPGRPTDAKQSVVELQIEVLDVNDNAPE 1169
               |.|..|:|  ||.:.:.:|||..|..:|...|.|   |....:::.|.:|:.|:|||||||.
Zfish  1393 ---FTIEPTSG--IVRTVRRLDRESVPFYELTAFAVD---RGVPPQRTPVHIQVSVMDVNDNAPV 1449

  Fly  1170 FTQKKYSTVIPENAQIDSFVLQLEAVDADEGLGGEVRYELVNEGEANGLFKIDTKSGLISTRRNL 1234
            |....:..::.||:.:.|.|.|:.|.|.|||...::.|::| ||....:|::|..||.:::..:|
Zfish  1450 FPADDFEVLVKENSAVGSVVAQITATDPDEGPNAQIMYQIV-EGNIPEIFQMDIFSGELTSLIDL 1513

  Fly  1235 TGKGRAHPYVLIVRAQDNGNQMPKQPTLSTDTDVRIYIGDVSANDGVPY----------FLSPRV 1289
            ..:.| :.||::|:|       ...|.:|..| |||.:  |..||..|.          |:|.|
Zfish  1514 DYETR-NEYVIVVQA-------TSAPLVSRAT-VRIRL--VDQNDNGPQMQDFQIIFNNFVSNR- 1566

  Fly  1290 GQMANVTENAVTGAPVFQVIASDPDDESTPSGTITYRILPDTPDAEAFVIDAHSGLITTRQSMDR 1354
               :|...:.|.|    :|.|.|||....     .|..:....:....:::..||.|...:.:|.
Zfish  1567 ---SNTFPSGVIG----RVPAHDPDVSDR-----LYYTIDRGNELHLLLLNHTSGEIRLSRKLDN 1619

  Fly  1355 ETKDMYRILLEVSDNGQPKQSATRILQIAIL-------DVDDHEPRFAREADAGPL-------SM 1405
            ....:..:|:.|:| |....||..:|::.|:       .:.......::|....||       ..
Zfish  1620 NRPLVAPMLITVTD-GIHSVSAQCVLRVLIITEEMLSSSITVRLQNMSQELFLSPLLTHFLDGVS 1683

  Fly  1406 SVREEEPAGTIVGNFSALDEDLGE--NAAIDYVIIDGNNEQLFTIERNNESLAILKTK-KPIDRE 1467
            :|....|....|.|... |.|.|:  |.:....:..|   |.|..|...|.|.:.:.: ..:...
Zfish  1684 AVLSVSPDDVFVFNVQP-DADAGKVLNVSFSAALPGG---QFFPSEALEEQLYLNRPRLNALAHM 1744

  Fly  1468 QVESFTLTIKCLKLGEPGYKFIGDPYDRQDLSHLRINVRVLDIDDNLPKFEQPDPTVGIRINVP 1531
            :|..|...: ||:  ||...::      :.:|.||.|.....|......|....|..|:|...|
Zfish  1745 EVLPFDDNV-CLR--EPCQNYM------KCISVLRFNSSAPFIASPSTLFRPIHPITGLRCRCP 1799

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.