DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tap and TWIST1

DIOPT Version :9

Sequence 1:	NP_524124.1	Gene:	tap / 39935	FlyBaseID:	FBgn0015550	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_000465.1	Gene:	TWIST1 / 7291	HGNCID:	12428	Length:	202	Species:	Homo sapiens

Alignment Length:	175	Identity:	50/175 - (28%)
Similarity:	76/175 - (43%)	Gaps:	32/175 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 PPAGFVGLLDTSSNHSTRSGRTLVEHLNSRATNGVFDP-PLTSTPVKSPEDPNAP----RPKRKY 132
            ||:|..|      ....||.|        |:..|...| ......|...::|.:|    |.|:..
Human    29 PPSGKRG------GRKRRSSR--------RSAGGGAGPGGAAGGGVGGGDEPGSPAQGKRGKKSA 79

  Fly   133 AV--------GKNRVTRSRSPTQVVKIKRFRRMKANDRERNRMHNLNDALEKLRVTLPSLPEETK 189
            ..        |....:...||....:::. :|:.||.|||.|..:||:|...||..:|:||.: |
Human    80 GCGGGGGAGGGGGSSSGGGSPQSYEELQT-QRVMANVRERQRTQSLNEAFAALRKIIPTLPSD-K 142

  Fly   190 LTKIEILRFAHNYIFALEQVLESGGSINLDLEKLQNFTLSGERIT 234
            |:||:.|:.|..||..|.|||:|.   .||.:......::.||::
Human   143 LSKIQTLKLAARYIDFLYQVLQSD---ELDSKMASCSYVAHERLS 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tap	NP_524124.1	HLH	155..207	CDD:278439	23/51 (45%)
TWIST1	NP_000465.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105		18/89 (20%)
		HLH	109..159	CDD:278439	23/50 (46%)
		Sufficient for transactivation activity. /evidence=ECO:0000250	161..191		8/27 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910