DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tap and Atoh8

DIOPT Version :9

Sequence 1:	NP_524124.1	Gene:	tap / 39935	FlyBaseID:	FBgn0015550	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_722473.1	Gene:	Atoh8 / 71093	MGIID:	1918343	Length:	322	Species:	Mus musculus

Alignment Length:	241	Identity:	62/241 - (25%)
Similarity:	93/241 - (38%)	Gaps:	76/241 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 QLSSRRRLDFG---------TPPTPAIPQPYSGGTWDA-----------VPLSSPPAGFVGLLDT 83
            ::|..|:..|.         |||.|...|..:.|..:|           :.|.:|||
Mouse   105 EVSDARKRGFALGTVGPGLPTPPPPPASQSLAPGDPEAHSFREQALRPRILLCAPPA-------- 161

  Fly    84 SSNHSTRSGRTLVEHLNSRATNGV-FDPPLTSTPVKSPEDPNAP-RPKR------KYAVGKNRVT 140
                              |.|... ..||  :.|.:||..|..| ||..      .:.:..|...
Mouse   162 ------------------RPTQSAPLAPP--AAPQESPVRPAPPTRPGESSYSSISHVIYNNHPD 206

  Fly   141 RSRSP-----------TQVVKIKRFRRMKANDRERNRMHNLNDALEKLRVTLPSLPEETKLTKIE 194
            .|.||           |::..:::.||:.||.|||.|:|.::.|.|.||..:|......||:|:.
Mouse   207 SSASPRKRPGEATAASTEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLA 271

  Fly   195 ILRFAHNYIFALEQVLE---SGGSINLDLEKLQNFTLSGERITKEL 237
            |||.|.|||.:|.::.:   |....||      :|:...:|.|:.|
Mouse   272 ILRIACNYILSLARLADLDYSADHSNL------SFSECVQRCTRTL 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tap	NP_524124.1	HLH	155..207	CDD:278439	24/51 (47%)
Atoh8	NP_722473.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..96
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..144		10/38 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..221		18/89 (20%)
		Basic motif, degenerate. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	231..244		7/12 (58%)
		HLH	232..283	CDD:278439	24/50 (48%)
		Helix-loop-helix motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00981	245..283		16/37 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3898
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810