Protein Alignment tap and NEUROD6

DIOPT Version :10

• Sequence 1: NP_524124.1
• Gene: tap / 39935
• FlyBaseID: FBgn0015550
• Length: 398
• Species: Drosophila melanogaster
• Sequence 2: NP_073565.2
• Gene: NEUROD6 / 63974
• HGNCID: 13804
• Length: 337
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 81/268 - (30%)
• Similarity: 117/268 - (43%)
• Gaps: 50/268 - (18%)

  Fly   118 KSPEDPNAPRPKRKYAVGKNRVTRSRSPTQVVKIKRFRRMKANDRERNRMHNLNDALEKLRVTLP 182
            :..||.|. .|:|: .:.|.:.|:.|    :.::| |||.:||.|||||||.|||||:.||..:|
Human    65 REEEDENG-LPRRR-GLRKKKTTKLR----LERVK-FRRQEANARERNRMHGLNDALDNLRKVVP 122

  Fly   183 SLPEETKLTKIEILRFAHNYIFALEQVLESGGSINLDLEKLQNFTLSGERITKELFDALFVNPQP 247
            ...:..||:|||.||.|.|||:||.::|..|...:| |..:||......:.|..|.....
Human   123 CYSKTQKLSKIETLRLAKNYIWALSEILRIGKRPDL-LTFVQNLCKGLSQPTTNLVAGCL----- 181

  Fly   248 YPLFGRMFPYGQGMAPLAQHQTAPAS------HAEQ---PPAMGGFQHG-MDYPQQPPGFDFTGS 302
             .|..|.|..||| ...|.|..:|.|      |:.:   ||.     || :|..:....:::..:
Human   182 -QLNARSFLMGQG-GEAAHHTRSPYSTFYPPYHSPELTTPPG-----HGTLDNSKSMKPYNYCSA 239

  Fly   303 MR-FYHQQQQQPHQPHH---LQPNPQQESSPQQFSQEKYDLFRGSFDAAANLHSTNLDSGIHQQS 363
            .. ||.....:...|..   |.|.|...:......||:      :.|     :..|.:.|:|
Human   240 YESFYESTSPECASPQFEGPLSPPPINYNGIFSLKQEE------TLD-----YGKNYNYGMH--- 290

  Fly   364 SFYSQTPP 371
              |...||
Human   291 --YCAVPP 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tap	NP_524124.1	bHLH_TS_NGN	155..211	CDD:381434	32/55 (58%)
NEUROD6	NP_073565.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..82		5/18 (28%)
		Nuclear localization signal. /evidence=ECO:0000255	80..86		1/5 (20%)
		bHLH_TS_NeuroD6_ATOH2	82..151	CDD:381565	36/73 (49%)
		Neuro_bHLH	153..272	CDD:463621	29/131 (22%)