DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tap and ATOH1

DIOPT Version :9

Sequence 1:	NP_524124.1	Gene:	tap / 39935	FlyBaseID:	FBgn0015550	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_005163.1	Gene:	ATOH1 / 474	HGNCID:	797	Length:	354	Species:	Homo sapiens

Alignment Length:	379	Identity:	88/379 - (23%)
Similarity:	126/379 - (33%)	Gaps:	138/379 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DFGTPPTP-AIPQPYSGGTWDAVPLSSPPAGF-----------VGLLDTSSNHSTRSGRTLVEHL 99
            |....|.| .:|||        .|...|||..           :.||| |::.......||....
Human    18 DHHRQPQPHHLPQP--------PPPPQPPATLQAREHPVYPPELSLLD-STDPRAWLAPTLQGIC 73

  Fly   100 NSRATNGVF-DPPLTSTPVKSPED------------------PNAPRP----------KRKYAVG 135
            .:||...:. .|.|.::...:|.|                  ..:|.|          |....|.
Human    74 TARAAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSPGPVKVREQLCKLKGGVVVD 138

  Fly   136 KNRVTRSRSPT--QVVKIKRFRRMKANDRERNRMHNLNDALEKLRVTLPSLPEETKLTKIEILRF 198
            :...:|.|:|:  ||..:::.||:.||.|||.|||.||.|.::||..:||...:.||:|.|.|:.
Human   139 ELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQM 203

  Fly   199 AHNYIFALEQVLE--SGGSINLDLEKLQNFTLSGERITKELFDALFVNPQPYPL----------F 251
            |..||.||.::|:  |||.                            .|.|.|.          .
Human   204 AQIYINALSELLQTPSGGE----------------------------QPPPPPASCKSDHHHLRT 240

  Fly   252 GRMFPYGQGMAPLA---------QHQTAPAS---HAEQPPAMGGFQHGMD--------------- 289
            ...:..|.|.|..|         |..|.|.|   ....|.:.||:...:|
Human   241 AASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLDALHFSTFEDSALTAM 305

  Fly   290 ------YPQQPPGFDFTGSMRFYHQQQQQPHQPHHLQPNPQQESSPQQFSQEKY 337
                  .|..|      ||:       .||.|..:.:.:|:...|..:||...:
Human   306 MAQKNLSPSLP------GSI-------LQPVQEENSKTSPRSHRSDGEFSPHSH 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tap	NP_524124.1	HLH	155..207	CDD:278439	26/51 (51%)
ATOH1	NP_005163.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..122		3/30 (10%)
		HLH	158..216	CDD:238036	27/57 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..277		14/88 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..354		11/48 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145435
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840