DRSC/TRiP Functional Genomics Resources

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Protein Alignment brv2 and PKD2L1

DIOPT Version :10

Sequence 1:NP_648970.2 Gene:brv2 / 39932 FlyBaseID:FBgn0036712 Length:736 Species:Drosophila melanogaster
Sequence 2:NP_057196.2 Gene:PKD2L1 / 9033 HGNCID:9011 Length:805 Species:Homo sapiens


Alignment Length:766 Identity:170/766 - (22%)
Similarity:282/766 - (36%) Gaps:204/766 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 IQSIDYATWPQEDPPYRAEEGGPTMDHIGYLKI--------------------RLRSLRSE---- 106
            :|.:....|  ::|.|    .||...| |.|::                    :..:.|::    
Human    12 LQKLGSGAW--DNPAY----SGPPSPH-GTLRVCTISSTGPLQPQPKKPEDEPQETAYRTQVSSC 69

  Fly   107 -LLISEG-----------HTNEMLNQKYKHIAGDLLLYGSYFIALMLMVVLQEDHTNYYNTNNMQ 159
             |.|.:|           :|.|......|....:||:|..:.:.:.|:.......:.||.|..|.
Human    70 CLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMS 134

  Fly   160 RLFWDNTSVTFGLSQVYFIYQVHSYM-------KITLVEAFYAQKTNGYEGWWAME--------- 208
            .||....|.| |:|     :|..|.|       :..|:::.|..|      |:..:         
Human   135 ELFLHTPSDT-GVS-----FQAISSMADFWDFAQGPLLDSLYWTK------WYNNQSLGHGSHSF 187

  Fly   209 ---QWQKIGVVRLRQM--RPVDCHIGLGKPEWDKKTYAPEWRLPYHRMHYTEKFWRIYDPFVPAE 268
               :...:||.||||:  |...|.:                    |. .:.|.....||.:.|.:
Human   188 IYYENMLLGVPRLRQLKVRNDSCVV--------------------HE-DFREDILSCYDVYSPDK 231

  Fly   269 -----FEPSFLNGLLLNY---------DHYGYLLNYPEVAGYVVLMMSTKINCLKQIEYLRDYSW 319
                 |.|  .||....|         .|:|.|.:| ...||.:.:..::....:.:..|::..|
Human   232 EEQLPFGP--FNGTAWTYHSQDELGGFSHWGRLTSY-SGGGYYLDLPGSRQGSAEALRALQEGLW 293

  Fly   320 LDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQLPRVHVDSVSMLGNVETRSNSELLI--- 381
            ||:.|..:|||.::|||:.|||.::.|.||....|..:|...:.:|.::..|   ||.:..|   
Human   294 LDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYV---SNWDFFIVGC 355

  Fly   382 -------LFVYTVLVILFARGVFTKIWHHPAAAHEAWTMVDLAIYILNVFLTVLAIMRDIETD-- 437
                   :|.|.|..||...      .|........|.::||.:.:|::......|.|.:|.:  
Human   356 EVIFCVFIFYYVVEEILELH------IHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRL 414

  Fly   438 --ALLQIIETATKGQYLDFQRPLRLHQMLFIVKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAW 500
              .|||...|....::|.|.:  ..:..:..|..|...|   :::|.:.|.......:.||....
Human   415 MGKLLQQPNTYADFEFLAFWQ--TQYNNMNAVNLFFAWI---KIFKYISFNKTMTQLSSTLARCA 474

  Fly   501 RAVASLGVIILVVLMA---IGITLAVPNGNNAVVFSHMVQSVVTCMWYSMGFNGDIHPADFFHGG 562
            :.:....|:..:|..|   :|..|.   |.....||..::.:.|.....:| :.|.:..|  :..
Human   475 KDILGFAVMFFIVFFAYAQLGYLLF---GTQVENFSTFIKCIFTQFRIILG-DFDYNAID--NAN 533

  Fly   563 RILGILLYLALVFLLAIILMNVFASVIYDYFNET-------------SRILKEHSNRSSITFLEF 614
            ||||...::..||.:..:|:|:|.::|.|.::|.             |.:||:..|::.:. |..
Human   534 RILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLR-LRL 597

  Fly   615 LHVEYADL------------FGDAFRCLRKTYESRGHTVAENVELELNRRELIKFKRD----LIK 663
            .....:|:            |.|....||:.    ||...|..||...   ..||.||    |.:
Human   598 RKERVSDVQKVLQGGEQEIQFEDFTNTLREL----GHAEHEITELTAT---FTKFDRDGNRILDE 655

  Fly   664 SPQELKRALLTEEQRSADYRLRGEKLFKLMAILNLQVEILERMVLGDKDGK 714
            ..||..|..| ||:|.|               ||.::|.|.|.::....||
Human   656 KEQEKMRQDL-EEERVA---------------LNTEIEKLGRSIVSSPQGK 690

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brv2NP_648970.2 Polycystin_dom 171..368 CDD:466668 53/231 (23%)
PKD_channel 369..596 CDD:462341 53/243 (22%)
PKD2L1NP_057196.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59 9/53 (17%)
Polycystin_dom 147..342 CDD:466668 52/229 (23%)
PKD_channel 343..567 CDD:462341 53/243 (22%)
Fer4_24 702..735 CDD:436280
Required for homooligomerization 704..763
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 759..805
Blue background indicates that the domain is not in the aligned region.

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