DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv2 and Pkd1l2

DIOPT Version :9

Sequence 1:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_036010263.1	Gene:	Pkd1l2 / 76645	MGIID:	2664668	Length:	2466	Species:	Mus musculus

Alignment Length:	718	Identity:	166/718 - (23%)
Similarity:	273/718 - (38%)	Gaps:	149/718 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SISRKDLTCFGVTTCVVMVCFVLVSIFSGFMHEPQRFKTM--------------LVTIVLVFFFQ 55
            |.||...:..|:....|:|.::||:..||.    ..|.||              |:::.:.|...
Mouse  1807 STSRVSKSPRGLPWWCVLVGWLLVATTSGV----AAFFTMLYGLHYGRVSSLKWLISMAVSFVES 1867

  Fly    56 YLILEPIR------FFI----QSIDYATWPQEDPPYRAEEGGPTMDHIGYLKIRLRSLRSE---- 106
            ..|.:|::      ||.    :..|..|.|..  |......||     |.| .|.|...||
Mouse  1868 VFITQPLKVLGFAAFFALVLKREDDEETLPLF--PGHLSSPGP-----GVL-FRSRRHSSERAYQ 1924

  Fly   107 ----LLISEGHTNEMLNQKYKHIAGDLLLYGSYFIALMLMVVLQEDHTNYYNTNNMQRLFWDNTS 167
                ..|.:..|..:..||...:..::|.|.::...|:|:...|.|...|:...:::|.|....|
Mouse  1925 PPPMAAIEKMKTTRLKEQKAFALIREILAYLAFLWMLLLVAYGQRDPNAYHFHRHLERSFSQGFS 1989

  Fly   168 VTFGLSQVYFIYQVHSYMKITLVEAFYAQKTNGYEGWWAMEQWQKIGVVRLRQMRPVD------- 225
            ...|....:      .:...|||:..|..    :.|:......:.:|...:||:|..:
Mouse  1990 PVLGFRGFF------EWANTTLVKNLYGH----HPGFVTDGNSKLVGSAHIRQVRVRESSCAVAQ 2044

  Fly   226 --------CH----IGLGKPEWDKKTYAPEWRL-PYHRMHYTEKFWRIYDPFVPAEFEPSFLNGL 277
                    ||    :|:.    |...|...|.. .|:..:...:.||..        ..|...|
Mouse  2045 QLQDSLDGCHGPYSLGIE----DLVDYGEGWNASAYNNSNGFPQAWRYQ--------SQSQRRG- 2096

  Fly   278 LLNYDHYGYLLNYPEVAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFT 342
               |..:|.|..|.. .||||.:.:...:..:.::||.|.||||..|.|:|::.|:|||:.|||.
Mouse  2097 ---YPMWGKLTLYGG-GGYVVPLGTDHQSASRILQYLFDNSWLDALTRAVFVEFTVYNANVNLFC 2157

  Fly   343 LITLRVENSPFGIQLPRVHVDSVSML-------GNVETRSNSELLILFVYTVLVILFAR----GV 396
            .:||.:|.|..|.....|.:.|:.:.       ..|.....:..|.||.|.|:.....|    |.
Mouse  2158 TVTLTLETSGLGTFFSHVTLQSLRLYPFTDGWHPFVVAAELTYFLFLFYYMVVQGKLMRKQKWGY 2222

  Fly   397 FTKIWHHPAAAHEAWTMVDLAIYILNVFLTVLAIMRDIETDALLQ-IIETATKGQYLDFQRPLRL 460
            |.          ..|.::::||.:.:....|:.:.|.|..|..|| ..|...:|  :.|......
Mouse  2223 FC----------SKWNLLEVAIILASWSALVVFVKRTILADRDLQRYREHRDEG--ISFSETAAA 2275

  Fly   461 HQMLFIVKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGITLAVPN 525
            ...|..:..|||.::|::||.:|:........|..|..||..::....:||::|:|......:..
Mouse  2276 DAALGYIIAFLVLLSTVKLWHLLRLNPKMNMITSALRRAWGDISGFVAVILIMLLAYSFASNLVF 2340

  Fly   526 GNNAVVFSHMVQSVVTCMWYSMG-FNG----DIHPADFFHGGRILGILLYLALVFLLAIILMNVF 585
            |.....:..:..:..|.:...:| ||.    |..|        |||.||..:.:..:..:::|:|
Mouse  2341 GWKLRSYKTLFDAAETMVSLQLGIFNYEEVLDYSP--------ILGSLLIGSCIVFMTFVVLNLF 2397

  Fly   586 ASVIYDYFNETSRILK-----EHSNRSSITFLEFLHVEYADLFGDAFRCLR-KTYESRGHTVAEN 644
            .|||...|:|..:..:     |.::...:..|.||.:          ||.| :|:.|     :|.
Mouse  2398 ISVILVAFSEEQKSDQLWEEGEIADLLLVKILSFLGI----------RCKREETWSS-----SEQ 2447

  Fly   645 VEL 647
            .||
Mouse  2448 PEL 2450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	108/463 (23%)
Pkd1l2	XP_036010263.1	CLECT	28..154	CDD:214480
		Gal_Lectin	170..252	CDD:396628
		REJ	493..866	CDD:366875
		GPS	1282..1321	CDD:396408
		PLAT_polycystin	1392..1511	CDD:238850
		PKD_channel	1987..2407	CDD:400395	109/466 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5261
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.050