Protein Alignment brv2 and pkd2l1

DIOPT Version :10

• Sequence 1: NP_648970.2
• Gene: brv2 / 39932
• FlyBaseID: FBgn0036712
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: XP_695404.4
• Gene: pkd2l1 / 567026
• ZFINID: ZDB-GENE-030616-558
• Length: 862
• Species: Danio rerio
• Alignment Length: 744
• Identity: 164/744 - (22%)
• Similarity: 274/744 - (36%)
• Gaps: 196/744 - (26%)

  Fly    75 PQEDPPYRAEEGGPTMDH-------IGYLKIRLRSLRSELLISEGHTNEMLNQKYKHIAGDLLLY 132
            |.|: ||..::...||.:       ..:....::.|....|..:...|..||.|..  ..:||:|
Zfish   110 PLEN-PYLNQDKARTMPNEDKKSGCCSFFFRAIKGLWGTALRKDTKENPELNVKAN--LKELLIY 171

  Fly   133 GSYFIALMLMVVLQEDHTNYYNTNNMQRLFWD---NTSVTFGLSQVYFIYQVHSYMKITLVEAFY 194
            ..:.:.|.|:.........||.|..|..||.:   :..::|  |.:..:..|.:||:..|::..|
Zfish   172 IVFLVDLCLLTYGMTSSATYYYTKAMTDLFVNLPGSNGMSF--SSIGCMNDVWTYMEGPLLDNLY 234

  Fly   195 AQK-------TNGYEGWWAMEQWQKIGVVRLRQMR--------PVDCHIGLGKPEWDKKTYAPEW 244
            ..|       .||.:.:...|. ..:||.|:||::        |.|
Zfish   235 WTKWYNDEPLENGNQSFIYYEN-LLLGVPRVRQLKVKQNSCKVPTD------------------- 279

  Fly   245 RLPYHRMHYTEKFWRIYDPF-VPAEFEPSF--LNGLLLNY---------DHYGYLLNYPEVAGYV 297
                    :.::....:|.: :..|.:.:|  :||....|         .|:|.|..| ..||:.
Zfish   280 --------FKKEISDCFDVYNIKKEDDGAFGLINGTAWQYHSEKEIKGSSHWGLLTTY-SGAGFY 335

  Fly   298 VLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQLPRVHV 362
            ..:.:|:......:|.||:..|||:.|..||||.|.|||:.|||.:|.|.||....|..:|...:
Zfish   336 QDLTTTRDESAALLEDLRENLWLDRGTRVLFIDFTAYNANINLFCVIRLVVEFPATGGAIPSYQI 400

  Fly   363 DSVSMLGNVETRS----NSEL---LILFVYTVLVILFAR----GVFTKIWHHPAAAHEAWTMVDL 416
            .:|.::..|.|..    ..|:   :.:..|.|..||..|    ..||.||:          ::|:
Zfish   401 RTVKLIRYVTTWDYFIIGCEIVFCVFILYYIVEEILEFRIHKLSHFTSIWN----------ILDI 455

  Fly   417 AIYILNVFLTVLAIMRDIETDALLQIIETATKGQ-------YLDFQRPLRLHQMLFIVKGFLVCI 474
            .:.:|.|...|.:..|.|:.|.||        |.       |.||:              ||...
Zfish   456 VVILLAVVAIVFSAFRTIKVDGLL--------GNLLKQPDIYADFE--------------FLAFW 498

  Fly   475 TT--------------LRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMA---IGITLA 522
            .|              ::::|.:.|.......|.||......:....::..:|..|   :|..|.
Zfish   499 QTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLTSTLARCALDIFGFAIMFFIVFFAYAQLGYLLF 563

  Fly   523 VPNGNNAVVFSHMVQSVVTCMWYSMGFNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFAS 587
               |.....||...:.:.|.....:| :.|....|  ...|:||.:.:.:.||.:..:|:|:|.:
Zfish   564 ---GTEVETFSTFNKCIFTQFRIILG-DFDYDAID--RANRVLGPIYFFSYVFFVFFVLLNMFLA 622

  Fly   588 VIYDYFNETSRILKEHSNRSSITFLEFLHVEYADLF----------GDA------------FRCL 630
            :|.|.::|....|.  |.:......:.:...||..|          .|.            |:..
Zfish   623 IINDTYSEVKSELA--SQKDEFQIADLIKQSYAKTFMKLKLKKEKISDVQKALDSGASELEFKDF 685

  Fly   631 RKTYESRGHTVAENVELELNRRELIKFKRD----LIKSPQE-LKRALLTEEQRSADYRLRGEKLF 690
            |...:..||:     :.|:: ....||.:|    |.|..|| :|:.|  ||:|.|
Zfish   686 RNALKEMGHS-----DREIS-AAFSKFDQDGNQTLDKQEQENMKQEL--EEKRDA---------- 732

  Fly   691 KLMAILNLQVEILERMVLGDKDGKLPTPP 719
                 |:.::..||..|...::.:...||
Zfish   733 -----LSAELRDLENSVEPAEEHRNTVPP 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	Polycystin_dom	171..368	CDD:466668	55/223 (25%)
		PKD_channel	369..596	CDD:462341	54/261 (21%)
pkd2l1	XP_695404.4	None