Protein Alignment brv2 and PKD2

DIOPT Version :10

• Sequence 1: NP_648970.2
• Gene: brv2 / 39932
• FlyBaseID: FBgn0036712
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: NP_000288.1
• Gene: PKD2 / 5311
• HGNCID: 9009
• Length: 968
• Species: Homo sapiens
• Alignment Length: 728
• Identity: 169/728 - (23%)
• Similarity: 280/728 - (38%)
• Gaps: 143/728 - (19%)

  Fly    76 QED--PPYRAEEGG--PTMDHIGY------------LKIRLRSLRSELLISEGHTNEMLNQKY-K 123
            :||  ||..:..||  |...|:..            |...||.|....|:.|..||   .:|| |
Human   157 REDQGPPCPSPVGGGDPLHRHLPLEGQPPRVAWAERLVRGLRGLWGTRLMEESSTN---REKYLK 218

  Fly   124 HIAGDLLLYGSYFIALMLMVVLQEDHTNYYNTNNMQRLFWDNTSVTFGLSQVYFIYQVHSYMKIT 188
            .:..:|:.|..:.|.|.::.........||.|..|.:||.|........:....:..:..:.|.|
Human   219 SVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFT 283

  Fly   189 ---LVEAFYAQKTNGYEGWWAMEQWQK---------------IGVVRLRQMR--------PVDCH 227
               |::..|          |.|:...:               :||.|:||:|        |.|..
Human   284 EGSLLDGLY----------WKMQPSNQTEADNRSFIFYENLLLGVPRIRQLRVRNGSCSIPQDLR 338

  Fly   228 IGLGKPEWDKKTYAPEWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLNYDHYGYLLNYPE 292
            ..: |..:|..:.:.|.|.|:...:.|.  | ||.       ....|||    ..|:|.:..| .
Human   339 DEI-KECYDVYSVSSEDRAPFGPRNGTA--W-IYT-------SEKDLNG----SSHWGIIATY-S 387

  Fly   293 VAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQL 357
            .|||.:.:..|:.....|:..|:...|||:.|.|.|||.::|||:.|||.::.|.||....|..:
Human   388 GAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVI 452

  Fly   358 PRVHVDSVSMLGNVET----RSNSELL---ILFVYTVLVILFARGVFTKIWHHPAAAHEAWTMVD 415
            |......:.::..|.|    .:..|::   .:|.|.|..||..|      .|........|..:|
Human   453 PSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEILEIR------IHKLHYFRSFWNCLD 511

  Fly   416 LAIYILNVFLTVLAIMRDIETDALLQIIETATKGQYLDFQRPLRLHQMLF-IVKGFLVCITTLRL 479
            :.|.:|:|....:.|.|....:.|||.:|  .:..:.:|:. |...|:.| .:....|....::|
Human   512 VVIVVLSVVAIGINIYRTSNVEVLLQFLE--DQNTFPNFEH-LAYWQIQFNNIAAVTVFFVWIKL 573

  Fly   480 WKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGITLAVPNGNNAVVFSHMVQSVVTCMW 544
            :|.:.|.......:.|:....:.:....::..::.:|......:..|.....||...:.:.|...
Human   574 FKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFR 638

  Fly   545 YSMGFNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNETSRILKEHSNRSSI 609
            ..:   |||:.|:.....|:||.:.:...||.:..||:|:|.::|.|.::|....|.:..
Human   639 IIL---GDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQK----- 695

  Fly   610 TFLEFLHVEYADLFGDAFRCLRKTYESRGHTVAENVELELNRRELI---------KFKRDLIKSP 665
                 ..:|.:||       :||.|    |.....::|:.|..:.|         |...|.::
Human   696 -----AEMELSDL-------IRKGY----HKALVKLKLKKNTVDDISESLRQGGGKLNFDELR-- 742

  Fly   666 QELK---------RALLTEEQRSADYRLRGEKLFKLMAILNLQVEILERMVLGDKD-GKLPTPPA 720
            |:||         .|:.|:..:..|..|...:..::...|..:.|.|      |.| ..||.|.:
Human   743 QDLKGKGHTDAEIEAIFTKYDQDGDQELTEHEHQQMRDDLEKEREDL------DLDHSSLPRPMS 801

  Fly   721 SDSDP---DDMPE 730
            |.|.|   ||..|
Human   802 SRSFPRSLDDSEE 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	Polycystin_dom	171..368	CDD:466668	54/222 (24%)
		PKD_channel	369..596	CDD:462341	50/234 (21%)
PKD2	NP_000288.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	58..181		8/23 (35%)
		Polycystin_dom	269..463	CDD:466668	54/219 (25%)
		PKD_channel	464..687	CDD:462341	50/234 (21%)
		Selectivity filter. /evidence=ECO:0000305|PubMed:28092368	641..643		0/4 (0%)
		EFh_HEF	<724..792	CDD:355006	14/75 (19%)
		EF-hand motif	754..782	CDD:320075	4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	764..831		16/57 (28%)
		Linker. /evidence=ECO:0000305|PubMed:18694932	803..822		5/12 (42%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000269|PubMed:15692563	810..821		3/5 (60%)
		Fer4_24	834..868	CDD:436280
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	917..968