Protein Alignment brv2 and pkd1l2a

DIOPT Version :10

• Sequence 1: NP_648970.2
• Gene: brv2 / 39932
• FlyBaseID: FBgn0036712
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: XP_017212723.2
• Gene: pkd1l2a / 497373
• ZFINID: ZDB-GENE-050208-89
• Length: 2484
• Species: Danio rerio
• Alignment Length: 669
• Identity: 154/669 - (23%)
• Similarity: 275/669 - (41%)
• Gaps: 140/669 - (20%)

  Fly    33 GFMHEPQRFKTMLVTIVLVFFFQYLILEPIR------FF---IQSIDYATWPQEDPPYRAEEGGP 88
            |..:..:|..:.|:::|:.||....|.:|::      ||   ::::|           :.|.|..
Zfish  1872 GLTYGKERSISWLISMVVSFFESLFITQPVKVLGFAVFFALVLKTVD-----------QDEYGDV 1925

  Fly    89 TMDHIGYLK-------IRLRSLRSELL---------ISEGHTNEMLNQKYKHIAGDLLLYGSYFI 137
            ::|  |.|.       :|:....|...         |.:...|.:..||...:..::|:|..:..
Zfish  1926 SID--GTLSNTDDPDAVRIARRDSTCSFYKPPPPTDIEKMRNNMIKEQKVFALIREILIYVGFLW 1988

  Fly   138 ALMLMVVLQEDHTNYYNTNNMQRLFWDNTSVTFGLSQVYFIYQVHSYMKITLVEAFYAQKTNGYE 202
            .|:|:...|.|...||.|:::::.|....|.|.....::.      :...:|:...|.|    |.
Zfish  1989 MLLLVAYGQRDPNAYYLTHHIRQSFSTGISETLNHKDIFI------WANSSLLRNLYGQ----YP 2043

  Fly   203 GWWAMEQWQKIGVVRLRQMR----------PV-----DCHIGLGKPEWDKKTYAPEWRLPYHRMH 252
            |:......:.:|..|:||:|          |:     |||........|..:|:|.|       :
Zfish  2044 GFITDGNSKLVGNARIRQVRVRRDTCKIANPMQYSVRDCHAPYSWESEDMGSYSPGW-------N 2101

  Fly   253 YTE---------KFWRIYDPFVPAEFEPSFLNGLLLNYDHYGYLLNYPEVAGYVVLMMSTKINCL 308
            .|.         |.| .|.........|.: .||.|   :.|        .|:||.:...:.|..
Zfish  2102 QTRNVNGSKTVLKPW-YYQTQAKLRANPVW-GGLAL---YKG--------GGFVVDLGPDQKNAS 2153

  Fly   309 KQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQLPRVHVDSVSMLG---- 369
            :.::||.|.:|||..|.|:|::.|:|||:.|||.::||..|.:..|....|..|.:|.:..
Zfish  2154 RLLQYLFDNTWLDVYTRAVFVEFTVYNANVNLFCIVTLIFETTGVGTFQYRSEVQAVHLYQSTGG 2218

  Fly   370 -NVETRSNSELLILFVYTVLVILFARGVFTK--IWHHPAAAHEAWTMVDLAIYI-----LNVFL- 425
             :|...::..:..:|:...:|:   :|...|  .|   |.....|.:::|||.|     |:||:
Zfish  2219 FHVFVMASEAIYYIFILYYMVV---QGKLMKQQKW---AYFKSKWNLLELAIIILSWSALSVFVK 2277

  Fly   426 -TVLAIMRDIE-----TDALLQIIETATKGQYLDFQRPLRLHQMLFIVKGFLVCITTLRLWKVLQ 484
             |:|. .||||     .|..:...||||....|.:            :..|||.:.|::||.:|:
Zfish  2278 RTILG-NRDIEFYQNNKDMFVSFNETATADAVLGY------------LIAFLVLLATIKLWHLLR 2329

  Fly   485 FASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGITLAVPNGNNAVVFSHMVQSVVTCMWYSMG- 548
            ........|.||..||..::...|::.::.:|..|...:..|.....:..::::..|.:...:|
Zfish  2330 LNPKLHMITSTLQRAWTDISGFIVVMTIMFLAYSIACNLMYGWRLNSYRTLLEAAQTIICLQLGI 2394

  Fly   549 FNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNETSRILKEHSNRSSITFLE 613
            ||.|    :......:||..|..:.:..:..:::|:|.|||...||| .::....|....|  :|
Zfish  2395 FNYD----EVLDYNPVLGAFLIGSCIIFMTFVVLNLFISVILVAFNE-EQLHPTPSEEEEI--VE 2452

  Fly   614 FLHVEYADLFGDAFRCLRK 632
            .:.::...|.|  .:|.:|
Zfish  2453 LMLMKVCSLLG--IKCKKK 2469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	Polycystin_dom	171..368	CDD:466668	54/220 (25%)
		PKD_channel	369..596	CDD:462341	58/246 (24%)
pkd1l2a	XP_017212723.2	CLECT	40..159	CDD:153057
		Gal_Rha_Lectin_PKD1L2	162..260	CDD:438688
		PKD	275..346	CDD:214510
		REJ	<632..918	CDD:366875
		GPS	1298..1343	CDD:470616
		PLAT_polycystin	1406..1525	CDD:238850
		Polycystin_dom	2025..2213	CDD:466668	54/217 (25%)
		PKD_channel	2218..2437	CDD:462341	57/241 (24%)