Protein Alignment brv2 and pkd2

DIOPT Version :10

• Sequence 1: NP_648970.2
• Gene: brv2 / 39932
• FlyBaseID: FBgn0036712
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: XP_073792981.1
• Gene: pkd2 / 432387
• ZFINID: ZDB-GENE-040827-4
• Length: 928
• Species: Danio rerio
• Alignment Length: 757
• Identity: 160/757 - (21%)
• Similarity: 281/757 - (37%)
• Gaps: 179/757 - (23%)

  Fly    72 ATWPQEDPPYR-------AEEGG--------------------PTMDHIGYLKIRLRSLR----S 105
            |.||.|....|       :..||                    |..:|....|..|..:|    :
Zfish    99 ADWPPESQGRRSVSTTSSSSSGGVPGNFSGISARINRGLYPTPPAQEHRSCGKRILEKMRVLWDT 163

  Fly   106 ELLISEGHTNEMLNQKYKHIAGDLLLYGSYFIALMLMVVLQEDHTNYYNTNNMQRLFWDNTSVTF 170
            .||   |.:|.......|.:..:::.|..:.:.|.::.........||.|..|.:||.| |.::.
Zfish   164 RLL---GESNSNREMYLKTVLREMITYILFLLTLCIITYGMVSTNMYYYTKVMSQLFLD-TPLSS 224

  Fly   171 GLSQVYFIYQVHSYMKITLVEAFYAQKTNG-------YEGWW---AMEQWQK--------IGVVR 217
            |        :..::..::.:|.|: :.|.|       :|.|:   ::.:.|.        :||.|
Zfish   225 G--------EPTNFKSLSTMEDFW-KFTEGPFLNGMYWELWYNNKSLPENQSLIYYENLLLGVPR 280

  Fly   218 LRQMR----PVDCHIGLGKPEWD-KKTYAP--EWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLN 275
            |||:|    ....|..|....:| ...|:|  |.:.|:...:.|.  ||..|       |.|
Zfish   281 LRQLRVRNESCSVHEDLRDEVYDCYNVYSPANEDKAPFGPKNGTA--WRFKD-------ESS--- 333

  Fly   276 GLLLNYDHYGYLLNYPEVAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANL 340
              |....::|.:..|.. .||...:..|:.....|::.|::..|||:.|.|:|:|.::||.:.||
Zfish   334 --LGESSYWGQVSTYGG-GGYYQDLSRTREKSANQLQELKNNLWLDRGTRAVFLDFSIYNGNVNL 395

  Fly   341 FTLITLRVENSPFGIQLPRVHVDSVSML----------GNVETRSNSELLILFVYTVLVILFARG 395
            |.::.|.||....|..:|.....:|.:|          |..|        :.|...||..|....
Zfish   396 FCIVRLLVEFPATGGAVPSWQFQTVRLLRYVSSWDYFVGMCE--------VSFCLFVLYYLVEEA 452

  Fly   396 VFTKIWHHPAAAHEAWTMVDLAIYILNVFLTVLAIMRDIETDALLQIIETATKGQYLDFQRPLRL 460
            :..:: |........|..:|:.|..|:|...::.|.|.......|..: ......|.:|:...||
Zfish   453 LEIRL-HRLRYFKSLWNCLDVLIVALSVPAIIMNICRTSAVSHRLHFL-LENHSTYPNFEPLARL 515

  Fly   461 HQMLFIVKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGITLAVPN 525
            ......:...:|.::.::|:|.:.|.......:.|:....:.:....::..:|.:|......:..
Zfish   516 QVHFNNLAAIIVFLSWVKLFKFINFNKTMNQLSTTMSRCAKDLMGFAIMFFIVFLAYAQLAYLVF 580

  Fly   526 GNNAVVFSHMVQSVVTCMWYSMG-FN-GDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASV 588
            |.....||.....:.|.....:| |: .:|..||     .:||.:.:...||.:.:||:|:|.::
Zfish   581 GTQVNDFSTFQACIFTQFRIILGDFDFSEIEEAD-----SVLGPIYFTTFVFFIFMILLNMFLAI 640

  Fly   589 IYDYFNETSRILKEHSNRSSITFLEFLHVEYADLFGDAFRCLRKTYESRGHTVAENVELELNRRE 653
            |.|.::|....:.:..:...||.|                 ::|:|                .|.
Zfish   641 INDTYSEVKADMAQQRSEMEITDL-----------------IKKSY----------------NRA 672

  Fly   654 LIKFKRDLIKS-----PQELKRAL--LTEEQRSADYRLRGEKLFKLMAI-----LNLQVEIL--- 703
            ::|.|  |.||     |..|::|.  |:.::...|.|.:|....::.||     |:...|:.
Zfish   673 MVKLK--LKKSSINDIPDSLQQAAGKLSFDELRQDLRGKGHSDAEIEAIFAKYDLDGDQELTEHE 735

  Fly   704 ----------ERMVLGDKDGKLPTPPA--------SDSDPDD 727
                      ||..|..:...||.|.:        .||:.||
Zfish   736 HQQMRDDLEKEREDLDLEHSSLPRPASGRSFSRSQDDSEEDD 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	Polycystin_dom	171..368	CDD:466668	54/221 (24%)
		PKD_channel	369..596	CDD:462341	45/228 (20%)
pkd2	XP_073792981.1	None