DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment brv2 and pkd2

DIOPT Version :9

Sequence 1:NP_648970.2 Gene:brv2 / 39932 FlyBaseID:FBgn0036712 Length:736 Species:Drosophila melanogaster
Sequence 2:NP_001002310.1 Gene:pkd2 / 432387 ZFINID:ZDB-GENE-040827-4 Length:904 Species:Danio rerio


Alignment Length:752 Identity:160/752 - (21%)
Similarity:283/752 - (37%) Gaps:169/752 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 ATWPQEDPPYR-------AEEGG--------------------PTMDHIGYLKIRLRSLR----S 105
            |.||.|....|       :..||                    |..:|....|..|..:|    :
Zfish    75 ADWPPESQGRRSVSTTSSSSSGGVPGNFSGISARINRGLYPTPPAQEHRSCGKRILEKMRVLWDT 139

  Fly   106 ELLISEGHTNEMLNQKYKHIAGDLLLYGSYFIALMLMVVLQEDHTNYYNTNNMQRLFWDNTSVTF 170
            .||   |.:|.......|.:..:::.|..:.:.|.::.........||.|..|.:||.| |.::.
Zfish   140 RLL---GESNSNREMYLKTVLREMITYILFLLTLCIITYGMVSTNMYYYTKVMSQLFLD-TPLSS 200

  Fly   171 GLSQVYFIYQVHSYMKITLVEAFYAQKTNG-------YEGWW---AMEQWQK--------IGVVR 217
            |        :..::..::.:|.|: :.|.|       :|.|:   ::.:.|.        :||.|
Zfish   201 G--------EPTNFKSLSTMEDFW-KFTEGPFLNGMYWELWYNNKSLPENQSLIYYENLLLGVPR 256

  Fly   218 LRQMR----PVDCHIGLGKPEWD-KKTYAP--EWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLN 275
            |||:|    ....|..|....:| ...|:|  |.:.|:...:.|.  ||..|       |.|   
Zfish   257 LRQLRVRNESCSVHEDLRDEVYDCYNVYSPANEDKAPFGPKNGTA--WRFKD-------ESS--- 309

  Fly   276 GLLLNYDHYGYLLNYPEVAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANL 340
              |....::|.:..|.. .||...:..|:.....|::.|::..|||:.|.|:|:|.::||.:.||
Zfish   310 --LGESSYWGQVSTYGG-GGYYQDLSRTREKSANQLQELKNNLWLDRGTRAVFLDFSIYNGNVNL 371

  Fly   341 FTLITLRVENSPFGIQLPRVHVDSVSMLGNVETRSNSELL-----ILFVYTVLVILFARGVFTKI 400
            |.::.|.||....|..:|.....:|.:|..|   |:.:..     :.|...||..|....:..::
Zfish   372 FCIVRLLVEFPATGGAVPSWQFQTVRLLRYV---SSWDYFVGMCEVSFCLFVLYYLVEEALEIRL 433

  Fly   401 WHHPAAAHEAWTMVDLAIYILNVFLTVLAIMRDIETDALLQIIETATKGQYLDFQRPLRLHQMLF 465
             |........|..:|:.|..|:|...::.|.|.......|..: ......|.:|:...||.....
Zfish   434 -HRLRYFKSLWNCLDVLIVALSVPAIIMNICRTSAVSHRLHFL-LENHSTYPNFEPLARLQVHFN 496

  Fly   466 IVKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGITLAVPNGNNAV 530
            .:...:|.::.::|:|.:.|.......:.|:....:.:....::..:|.:|......:..|....
Zfish   497 NLAAIIVFLSWVKLFKFINFNKTMNQLSTTMSRCAKDLMGFAIMFFIVFLAYAQLAYLVFGTQVN 561

  Fly   531 VFSHMVQSVVTCMWYSMG-FN-GDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYF 593
            .||.....:.|.....:| |: .:|..||     .:||.:.:...||.:.:||:|:|.::|.|.:
Zfish   562 DFSTFQACIFTQFRIILGDFDFSEIEEAD-----SVLGPIYFTTFVFFIFMILLNMFLAIINDTY 621

  Fly   594 NETSRILKEHSNRSSITFLEFLHVEYADLFGDAFRCLRKTYESRGHTVAENVELELNRRELIKFK 658
            :|....:.:..:...||.|                 ::|:|                .|.::|.|
Zfish   622 SEVKADMAQQRSEMEITDL-----------------IKKSY----------------NRAMVKLK 653

  Fly   659 RDLIKS-----PQELKRAL--LTEEQRSADYRLRGEKLFKLMAI-----LNLQVEIL-------- 703
              |.||     |..|::|.  |:.::...|.|.:|....::.||     |:...|:.        
Zfish   654 --LKKSSINDIPDSLQQAAGKLSFDELRQDLRGKGHSDAEIEAIFAKYDLDGDQELTEHEHQQMR 716

  Fly   704 -----ERMVLGDKDGKLPTPPA--------SDSDPDD 727
                 ||..|..:...||.|.:        .||:.||
Zfish   717 DDLEKEREDLDLEHSSLPRPASGRSFSRSQDDSEEDD 753

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brv2NP_648970.2 PKD_channel 169..596 CDD:285288 100/458 (22%)
pkd2NP_001002310.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..102 7/26 (27%)
PKD_channel 204..624 CDD:285288 99/445 (22%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:Q13563 578..580 0/1 (0%)
EFh <671..715 CDD:324233 8/43 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 708..770 10/46 (22%)
Linker. /evidence=ECO:0000250|UniProtKB:Q13563 740..759 4/14 (29%)
Pkinase <781..>856 CDD:330832
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 854..904
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3599
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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