Protein Alignment brv2 and brv1

DIOPT Version :10

• Sequence 1: NP_648970.2
• Gene: brv2 / 39932
• FlyBaseID: FBgn0036712
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Alignment Length: 724
• Identity: 254/724 - (35%)
• Similarity: 404/724 - (55%)
• Gaps: 16/724 - (2%)

  Fly    14 FGVTTCVVMVCFVLVSIFSGFMHEPQRFKTMLVTIVLVFFFQYLILEPIRFFIQSIDYATWPQED 78
            |.:|..::.:|...:.:||||.||..:|..:||..:.|...|.||..||:|.|.|:|.|.||...
  Fly    10 FYLTLIIIAICVACIWMFSGFRHEYGKFNMILVAFLAVTLLQILIFTPIKFTIMSLDAAFWPAHQ 74

  Fly    79 PPYRAEEGGPTMDHIGYLKIRLRSLRSELLISEGHTNEMLNQKYKHIAGDLLLYGSYFIALMLMV 143
            .|...:|.......:..|::|||:|||||:|:|.|.||.:|.||:.|..:|.|.|..|:....|.
  Fly    75 APETPDENANVDTFMDNLRLRLRTLRSELMITERHRNERVNLKYRLITEELWLTGKLFLVYFFMA 139

  Fly   144 VLQEDHTNYYNTNNMQRLFWDNTSVTFGLSQVYFIYQVHSYMKITLVEAFY-AQKTNGYEGWWAM 207
            :...|...|:||...:.||..|....|||..|..:..::.::..:||.||. .:.|:|...|...
  Fly   140 LAFFDELLYFNTEATELLFQCNHGDAFGLLSVGDVPDIYFFVVSSLVLAFTDGKNTSGGAPWIHA 204

  Fly   208 EQWQKIGVVRLRQMRPVDCHIGLGKPEWDKKTYAPEWRLPYHRMHYTEKFWRIYDPFVPAEFEPS 272
            |..:.:|||||||:|.....:||..|.:.::.::..|.|||.|:.||:|:|.||.|::|:.....
  Fly   205 EGTRLLGVVRLRQLRTESNRLGLSLPVFTERDFSESWTLPYERVPYTDKYWPIYTPWLPSVSVAR 269

  Fly   273 FLNGLLLNYDHYGYLLNYPEVAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNAD 337
              :.||:..:|.|::.||||..||.||:..|:...||.|:||...:|||.||:|||:|.::||||
  Fly   270 --DNLLMGINHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTALFMDFSLYNAD 332

  Fly   338 ANLFTLITLRVENSPFGIQLPRVH--VDSVSMLGNVETRSNSELLILFVYTVLVILFARGVFTKI 400
            ||.||:.||.||..|:  |.|..|  ::|.:.:..:...:...:|::||:.|..:.|.:..|.|:
  Fly   333 ANTFTVCTLWVEKFPY--QYPDGHTRIESHTFVEQLREFTKFGMLMVFVFVVTWLQFTKAFFLKV 395

  Fly   401 WHHPAAAHEAWTMVDLAIYILNVFLTVLAIMRDIETDALLQIIETATKGQYLDFQRPLRLHQMLF 465
            |:.|......|..||..|..|::.:.::..:||.....:::.:|.|....:|||:.|.:|..:..
  Fly   396 WYDPRQLKTLWVQVDAMIVALSLVVGMIMSVRDNLVQKMIKSVEIAVVVDFLDFREPAQLAYLED 460

  Fly   466 IVKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGITLAVPNGNNAV 530
            :|.|..|.:.|:||||||||::.||.||:|:..||.|:....||.::.::||||.....|||...
  Fly   461 VVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFIIAIGIATVTINGNYTS 525

  Fly   531 VFSHMVQSVVTCMWYSMGFNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNE 595
            .|....:.:||...::.|:...::|.|.|:||..||||||..:.|::..:|:|:..|::.|.. .
  Fly   526 NFRDFPKGIVTVTCFAFGYTNLVYPPDIFYGGEWLGILLYTIMGFVVKYMLINLIVSMMRDQM-A 589

  Fly   596 TSRILKEHSNRSSITFLEFLHVEYADLFG---DAFRCLRKTYESRGHTVAENVELELNRRELIKF 657
            :.:..::...|..|||.:||.||||....   ..|.| :|.|:.:..|||:|::.:||..||.:.
  Fly   590 SVKADRDKKVRQRITFWQFLRVEYAHFINYIVKVFHC-QKGYQRKNRTVAQNIQRKLNSNELKRR 653

  Fly   658 KRDLIKSPQELKRAL-LTEEQRSADYRLRGEKLFKLMAILNLQVEILERMVLGDKDGKLPTPPAS 721
            |..:.....|....: :.::.....||.|.|:.|.|.|||:.|:|::||::.||::|.|   |:.
  Fly   654 KTKISSIYSETIYVMPIDKDLEQMKYRERIERTFTLAAILHTQMELMERLMFGDEEGNL---PSL 715

  Fly   722 DSDPDDMPE 730
            |.:.:.:||
  Fly   716 DQEDEQVPE 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	Polycystin_dom	171..368	CDD:466668	79/199 (40%)
		PKD_channel	369..596	CDD:462341	72/226 (32%)
brv1	NP_649116.1	Polycystin_dom	167..363	CDD:466668	79/199 (40%)
		PKD_channel	364..591	CDD:462341	72/227 (32%)