DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brv2 and PKD1L3

DIOPT Version :9

Sequence 1:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_853514.1	Gene:	PKD1L3 / 342372	HGNCID:	21716	Length:	1732	Species:	Homo sapiens

Alignment Length:	701	Identity:	130/701 - (18%)
Similarity:	252/701 - (35%)	Gaps:	163/701 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSSISRKDLTCFGVTTCVVMVCFVLVSIFSGFMHEPQRFKTML--------------VTIVLVFF 53
            |||...|.....|::..:..||::|:    ||......|.|.|              ::|:|...
Human  1136 LSSEEGKKPISNGLSKWLTSVCWLLL----GFTSLASAFFTALYSLELSKDQATSWMISIILSVL 1196

  Fly    54 FQYLILEPIRFFIQSIDYATWPQEDPPYRAEEGGPTMDHIGYLKIRLRSLRSELLISEGHTNEM- 117
            ....|.:|::....:..|:......|....|....|...:..    |....|.:..|....|.:
Human  1197 QNIFISQPVKVVFFTFLYSLMMSRMPRLNKENEQQTKRILAL----LAKCSSSVPGSRDKNNPVY 1257

  Fly   118 ----LNQKYKH------------IAGDLLLYGSYFIALMLMVVLQEDHTNYYNTNNMQRLFWDNT 166
                :|...||            :.||:|:...:...||..:...::...:|    :.:..|...
Human  1258 VAPAINSPTKHPERTLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSNRFY----LHQAIWKTF 1318

  Fly   167 SVTFGLSQVYFIYQVHSYMKITLVEAFYAQKTN--------GYEGWWAMEQWQKIGVVRLRQMRP 223
            |              |.:.:|.|::.||....:        .|.|..|:             :.|
Human  1319 S--------------HQFSEIKLLQDFYPWANHILLPSLYGDYRGKNAV-------------LEP 1356

  Fly   224 VDCHIGLGK----PEWDKKTY--APEWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLNYD 282
            ..|..|:..    |.  .|||  ..|.:|.:....:|            .....|...||.|.
Human  1357 SHCKCGVQLIFQIPR--TKTYEKVDEGQLAFCDNGHT------------CGRPKSLFPGLHLR-- 1405

  Fly   283 HYGYLLNYPEVAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLR 347
            .:.|:.: |..   :||:.:.:::.....:....:|::.:  .|.|..|.:.:     ||.:.:.
Human  1406 RFSYICS-PRP---MVLIPTDELHERLTSKNENGFSYIMR--GAFFTSLRLES-----FTSLQMS 1459

  Fly   348 VENSPFGIQLPRVHVDSVSMLGNVETRSNSELLILFVYTVLVILFA--RGVFTKIWHHPAAAHEA 410
            .:...:.|         :|.:               :|.:||..:|  :|...|        .:.
Human  1460 KKGCVWSI---------ISQV---------------IYYLLVCYYAFIQGCQLK--------QQK 1492

  Fly   411 W-------TMVDLAIYILNVFLTVLAIMRDIETDALLQIIETATKGQYLDFQRPLRLHQMLFIVK 468
            |       .::|.:|.:::..|..|. |:.|.............:.:::.|...::::.....:.
Human  1493 WRFFTGKRNILDTSIILISFILLGLD-MKSISLHKKNMARYRDDQDRFISFYEAVKVNSAATHLV 1556

  Fly   469 GFLVCITTLRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGITLAVPNGNNAVVFS 533
            ||.|.:.|::||.:|:.:...:..::||..||..|....:|||::|....|...:..|.:...:.
Human  1557 GFPVLLATVQLWNLLRHSPRLRVISRTLSRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDYR 1621

  Fly   534 HMVQSVVTCMWYSMGFNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNETSR 598
            ....|.||.:...||.:   |..:.|....:||..|.|..|.|:.::::|:|.|.|...|.:..:
Human  1622 TFFSSAVTVVGLLMGIS---HQEEVFALDPVLGTFLILTSVILMVLVVINLFVSAILMAFGKERK 1683

  Fly   599 ILKEHSNRSSITFLEFLHVEYADLFGDAFRCLRKTYESRGHTVAENVELEL 649
            .||:.:     ..::.|..:.::|.|.::.  :||...:..|.|...:.|:
Human  1684 SLKKEA-----ALIDTLLQKLSNLLGISWP--QKTSSEQAATTAVGSDTEV 1727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	84/449 (19%)
PKD1L3	NP_853514.1	CLECT	33..138	CDD:153057
		GPS	633..672	CDD:295363
		PLAT_polycystin	743..859	CDD:238850
		PKD_channel	<1446..1678	CDD:285288	54/272 (20%)
		Channel pore-region	1613..1651		8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920