Protein Alignment brv2 and Pkd2l1

DIOPT Version :10

• Sequence 1: NP_648970.2
• Gene: brv2 / 39932
• FlyBaseID: FBgn0036712
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: NP_852087.2
• Gene: Pkd2l1 / 329064
• MGIID: 1352448
• Length: 760
• Species: Mus musculus
• Alignment Length: 644
• Identity: 143/644 - (22%)
• Similarity: 253/644 - (39%)
• Gaps: 114/644 - (17%)

  Fly   128 DLLLYGSYFIALMLMVVLQEDHTNYYNTNNMQRLFWDNTSVTFGLSQVYFIYQVHSYM------- 185
            :|::|..:.:.:.|:.......:.||.|..|..||. :|....|:|     :|..|.|
Mouse   103 ELVVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFL-HTPSDSGVS-----FQTISSMSDFWDFA 161

  Fly   186 KITLVEAFYAQKTNGYEGWWAMEQWQK------------IGVVRLRQMRPVDCHIGLGKPEWDKK 238
            :..|:::.|..|      |:..:...:            :|..||||:|..:          |..
Mouse   162 QGPLLDSLYWTK------WYNNQSLGRGSHSFIYYENLLLGAPRLRQLRVRN----------DSC 210

  Fly   239 TYAPEWRLPYHRMHYTEKFWRIYDPFVPAE-----FEPSFLNGLLLNY---------DHYGYLLN 289
            ....::|         |.....||.:.|.:     |.|.  ||....|         .|:|.|.:
Mouse   211 VVHEDFR---------EDILNCYDVYSPDKEDQLPFGPQ--NGTAWTYHSQNELGGSSHWGRLTS 264

  Fly   290 YPEVAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFG 354
            | ...||.:.:..::....:.::.|::..|||:.|..:|||.::|||:.|||.::.|.||....|
Mouse   265 Y-SGGGYYLDLPGSRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILRLVVEFPATG 328

  Fly   355 IQLPRVHVDSVSMLGNVETRSNSELLIL---FVYTVLVILFARGVFTKI-WHHPAAAHEAWTMVD 415
            ..:|...:.:|.::..|   :|.:..|:   .|:.|.:..:......:| .|........|.::|
Mouse   329 GTIPSWQIRTVKLIRYV---NNWDFFIVGCEVVFCVFIFYYVVEEILEIHLHRLRYLSSVWNILD 390

  Fly   416 LAIYILNVFLTVLAIMRDIETD----ALLQIIETATKGQYLDFQRPLRLHQMLFIVKGFLVCITT 476
            |.:.:|::......|.|.:|.:    .|||..:|....::|.|.:  ..:..:..|..|...|
Mouse   391 LVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPDTYADFEFLAFWQ--TQYNNMNAVNLFFAWI-- 451

  Fly   477 LRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMA---IGITLAVPNGNNAVVFSHMVQS 538
             :::|.:.|.......:.||....:.:....::..:|..|   :|..|.   |.....||..|:.
Mouse   452 -KIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLF---GTQVENFSTFVKC 512

  Fly   539 VVTCMWYSMGFNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNETSRILKEH 603
            :.|.....:| :.|.:..|  :..||||.:.::..||.:..:|:|:|.::|.|.::|....|.
Mouse   513 IFTQFRIILG-DFDYNAID--NANRILGPVYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELA-- 572

  Fly   604 SNRSSITFLEFLHVEYADLFGDAFRC-LRKTYESRGHTVAENVELELNRRELIKFKRDLIKSPQE 667
            ..:..:...:||...|....   .|. |||...|....|.:..|.|:...:.....|:|.....|
Mouse   573 GQKDQLQLSDFLKQSYNKTL---LRLRLRKERVSDVQKVLKGGEPEIQFEDFTSTLRELGHEEHE 634

  Fly   668 LKRA-----------LLTEEQRSADYRLRGEKLFKLMAILNLQVEILERMVLGDKDGKL 715
            :..|           |..|||......|..|::     .||.::|.|.|.|.....|:|
Mouse   635 ITAAFTRFDQDGDHILDEEEQEQMRQGLEEERV-----TLNAEIENLGRSVGHSPPGEL 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	Polycystin_dom	171..368	CDD:466668	52/229 (23%)
		PKD_channel	369..596	CDD:462341	50/237 (21%)
Pkd2l1	NP_852087.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		Polycystin_dom	147..342	CDD:466668	51/227 (22%)
		PKD_channel	343..567	CDD:462341	50/237 (21%)
		EFh	616..654	CDD:415501	5/37 (14%)
		Fer4_24	699..732	CDD:436280
		Required for homooligomerization. /evidence=ECO:0000250	701..760