Protein Alignment brv2 and Pkdrej

DIOPT Version :10

• Sequence 1: NP_648970.2
• Gene: brv2 / 39932
• FlyBaseID: FBgn0036712
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: NP_001128338.1
• Gene: Pkdrej / 300124
• RGDID: 1306587
• Length: 2121
• Species: Rattus norvegicus
• Alignment Length: 690
• Identity: 131/690 - (18%)
• Similarity: 270/690 - (39%)
• Gaps: 126/690 - (18%)

  Fly    19 CVVMVCFVLVS---------IFSGFMHEPQRFKTMLVTIVLVFFFQYLILEPIRFFIQSIDYATW 74
            ||.:..|::.:         :|.|..:...:....|......|.....:::|....::|    ..
  Rat  1444 CVYIAWFLVFATSGVSSFFIVFYGLTYGYDKSVEWLFASFCSFCQSVFLVQPCHILLRS----GT 1504

  Fly    75 PQEDPPYRAEEGGPTMDHIGYLKIRLRSLR----------------SELLISEGHTNEMLN--QK 121
            ....|.|.......:..|  |.:|||:.|:                ..|.|.:..|.:.:.  ::
  Rat  1505 RMHRPKYCKNLSWSSKYH--YTEIRLQELKMTPEETEQLHEDMAYIRSLSIYQPITEDKIQIFRR 1567

  Fly   122 YKHIAGDLLLYGSY------FIALMLMVV--LQEDHTNYYNTNNMQRLFWDNTSVTFGLSQVYFI 178
            ...|.....|:.||      |:.|:|:::  |:.:.:.|||.....|...|       |:.|..:
  Rat  1568 KNRIRKRSFLFLSYLVTHFIFLTLLLLLIFPLRHNDSFYYNQFVRHRFSMD-------LATVVKL 1625

  Fly   179 YQVHSYMKITLVEAFYAQKTNGYEGWWAMEQWQKI-GVVRLRQMR-------------------- 222
            ..:::::....:...:..|:..:    ..:...|| |:..:||:|
  Rat  1626 GDIYAWLNGVFLPLLHNDKSPTF----LPDSSSKILGLPLMRQVRAKPSNKTCLLAKKFAQSRIA 1686

  Fly   223 -PVDCHIGLGKPEWDKKTYAPEWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLNYDHYGY 286
             .:.||...|....|.:.|...|.....|..........|.|  |......:..|:|..|...||
  Rat  1687 GELHCHPQYGIDPEDTRHYPGVWNKAGKRSIDKTSNGFTYKP--PGRKWVYYSYGVLNTYGSGGY 1749

  Fly   287 -LLNYPEVAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVEN 350
             ...:||         ....|...:::.|...:|||:.|.|:.::||..|.|.:|...|::..|.
  Rat  1750 EFYFFPE---------QQMFNSTLRLKELEGKNWLDELTWAVIVELTTLNPDTSLMCSISVVFEV 1805

  Fly   351 SPFGIQLPRVHVDSVSMLGNVETRSNSELLILFVYTVLVILFARGV----FTKIWHHPAAAHEAW 411
            ||.|:....:.|.|.. |.:..:||::|   :::|..::|.|...|    :..:....:.....:
  Rat  1806 SPLGVVNSSLSVYSFP-LADFNSRSSAE---IYLYVAILIFFCAYVVDEGYIIMQERASYIRSMY 1866

  Fly   412 TMVDLAIYILNVFLTVLAIMRDIETDALLQIIETATKGQYLDFQRPLRLHQMLFIVKGFLVCITT 476
            .:::.::..:...|.||...:.:....|:::..|..:. ::.|....|:...:.|:..||:.:|.
  Rat  1867 NLLNFSLKCMFALLIVLFFQKHLLATKLVRLYNTDPEA-FIPFHAVSRVDHFMRIILAFLLFLTI 1930

  Fly   477 LRLWKVLQFASVFQHF---TQTLFSAWRAVASLGVIILV---VLMAIGITLAVPNGNNAVVFSHM 535
            |   |.|:::..|.:.   .:|:.:|:..:....:::.:   :.:|.|..:.   |.:...:|:|
  Rat  1931 L---KTLRYSRFFYNVRLAQKTIQAAFPGICHTALVVSIYSFMYVAFGYLVF---GQHEWNYSNM 1989

  Fly   536 VQSVVTCMWYSMGFNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNETSR-I 599
            :.:..|...|.:....:..    |.|.:|||:|...:.:.::..|.:|:|..||...::|..: :
  Rat  1990 IHATQTIFSYCVSAFQNTE----FSGNKILGVLFLSSFMLVMICIFINLFQVVILSAYDEMKQPV 2050

  Fly   600 LKEHSNRS-SITFL--------EFL-----HVEYADLFGD 625
            .:|.|:.: ::|:|        :||     ..:.:|.|.|
  Rat  2051 YEEPSDEAEAVTYLCDSLKSGFDFLTSGPQDKDQSDFFED 2090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	Polycystin_dom	171..368	CDD:466668	45/219 (21%)
		PKD_channel	369..596	CDD:462341	42/236 (18%)
Pkdrej	NP_001128338.1	REJ	132..598	CDD:366875
		PLAT_polycystin	1111..1226	CDD:238850
		Polycystin_dom	1618..1823	CDD:466668	46/227 (20%)
		PKD_channel	1825..2046	CDD:462341	42/234 (18%)