DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv2 and Pkd2l1

DIOPT Version :9

Sequence 1:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_038964804.1	Gene:	Pkd2l1 / 293937	RGDID:	1306261	Length:	763	Species:	Rattus norvegicus

Alignment Length:	705	Identity:	156/705 - (22%)
Similarity:	276/705 - (39%)	Gaps:	113/705 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 TWPQEDPPYRAEEGGPTMDHIGYLKIRLRSLRS--ELLISEGHTNEMLNQKYKHIAGDLLLYGSY 135
            |.|:: |..|.:|..|.:...|...:..|.:|.  ...::| :|.|......|....:|::|..:
  Rat    48 TQPKK-PEVRRQEKTPRVPVSGCCLLICRGIRGLWGTTLTE-NTAENRELYVKTTLRELVVYIVF 110

  Fly   136 FIALMLMVVLQEDHTNYYNTNNMQRLFW---DNTSVTFGLSQVYFIYQVHSYMKITLVEAFYAQK 197
            .:.:.|:.......:.||.|..|..||.   ..::|:|  ..:..:.....:.:..|:::.|..|
  Rat   111 LVDVCLLTYGMTSSSAYYYTKVMSELFLHTPSESAVSF--QTISSMSDFWDFAQGPLLDSLYWTK 173

  Fly   198 TNGYEGWWAMEQWQK------------IGVVRLRQMRPVDCHIGLGKPEWDKKTYAPEWRLPYHR 250
                  |:..:....            :||.||||:|..:          |......::|
  Rat   174 ------WYNNQSLGSSSHSFIYYENLLLGVPRLRQLRVRN----------DSCVVHEDFR----- 217

  Fly   251 MHYTEKFWRIYDPFVPAE-----FEPSFLNGLLLNY---------DHYGYLLNYPEVAGYVVLMM 301
                |.....||.:.|.:     |.|  |||....|         .|:|.|.:| ...||.:.:.
  Rat   218 ----EDILNCYDVYSPDKEDQLPFGP--LNGTAWTYHSQNELGGSSHWGRLTSY-SGGGYYLDLP 275

  Fly   302 STKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQLPRVHVDSVS 366
            .::....:.::.|::..|||:.|..:|||.::|||:.|||.::.|.||....|..:|...:.:|.
  Rat   276 GSRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILRLVVEFPATGGAIPSWQIRTVK 340

  Fly   367 MLGNVETRSNSELLI----------LFVYTVLVILFARGVFTKIWHHPAAAHEAWTMVDLAIYIL 421
            ::..|   :|.:..|          :|.|.|..||..|      .|........|.::||.:.:|
  Rat   341 LIRYV---NNWDFFIVGCEVIFCIFIFYYVVEEILEIR------VHRFRYLSSVWNILDLVVILL 396

  Fly   422 NVFLTVLAIMRDIETD----ALLQIIETATKGQYLDFQRPLRLHQMLFIVKGFLVCITTLRLWKV 482
            ::......:.|.:|.:    .|||..:|....::|.|.:  ..:..:..|..|...|   :::|.
  Rat   397 SIVAVGFHVFRTLEVNRLMGELLQQPDTYPDFEFLAFWQ--TQYNNMNAVNLFFAWI---KIFKY 456

  Fly   483 LQFASVFQHFTQTLFSAWRAVASLGVIILVVLMA---IGITLAVPNGNNAVVFSHMVQSVVTCMW 544
            :.|.......:.||....:.:....::..:|..|   :|..|.   |.....||..|:.:.|...
  Rat   457 ISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLF---GTQVESFSTFVKCIFTQFR 518

  Fly   545 YSMGFNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNETSRILKEHSNRSSI 609
            ..:| :.|.:..|  :..||||.:.::..||.:..:|:|:|.::|.|.::|....|.  ..|..:
  Rat   519 IILG-DFDYNAID--NANRILGPVYFITYVFFVFFVLLNMFLAIINDTYSEVKEELA--GQRDQL 578

  Fly   610 TFLEFLHVEYADLFGDAFRCLRKTYESRGHTVAENVELELNRRELIKFKRDLIKSPQELKR--AL 672
            ...:.|...|:... ...| |||...|....|.:..|.|:...:.....|:|..:.:|:..  |.
  Rat   579 QLSDLLKQSYSKTL-QRLR-LRKERVSDVQKVLKGGEPEIQFEDFTNTLRELGHAEREISEVSAA 641

  Fly   673 LTEEQRSADYRLRGEK-------LFKLMAILNLQVEILERMVLGDKDGKLPTPPA 720
            .|...|..|:.|..|.       |.:....|:.:.|.|.|.|.....|:|....|
  Rat   642 FTRFDRDGDHILDEEDQAQMRQGLEEERMTLSAETENLGRSVGHSPPGELDAEAA 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	102/469 (22%)
Pkd2l1	XP_038964804.1	PKD_channel	147..567	CDD:400395	102/469 (22%)
		Smc	<557..>743	CDD:224117	33/144 (23%)
		Fer4_24	702..735	CDD:407943
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46093
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820