Protein Alignment brv2 and Pkd2l2

DIOPT Version :10

• Sequence 1: NP_648970.2
• Gene: brv2 / 39932
• FlyBaseID: FBgn0036712
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: XP_063133288.1
• Gene: Pkd2l2 / 291683
• RGDID: 1310272
• Length: 623
• Species: Rattus norvegicus
• Alignment Length: 708
• Identity: 145/708 - (20%)
• Similarity: 258/708 - (36%)
• Gaps: 184/708 - (25%)

  Fly    72 ATWPQEDPPYRAEEGGPTMDH-IGYLKIRLRSLRSELLISEGHTNEMLNQKYKHIAGDLLLYGSY 135
            |||     .:|..||  |..| :.|.:             |...|..|.        :|||   |
  Rat     4 ATW-----WHRGGEG--TSKHDLHYRR-------------EAEVNTTLE--------ELLL---Y 37

  Fly   136 FIALMLMVVLQEDHTN---YYNTNNMQRLFWDNTSV----TFGLSQVYFIYQVHSYMKITLVEAF 193
            ||.|:.:.:|.....|   ||....|..||.| ||:    ......:..|.:...:|:..|||..
  Rat    38 FIFLINLCILTFGTVNPHMYYLNKVMSSLFVD-TSLPDDERSSFRSIRSITEFWKFMEGPLVEGL 101

  Fly   194 YAQKTNGYEGWWAMEQWQKI-------------GVVRLRQMRPVD--CHI-----GLGKPEWDKK 238
            |      ::.|:...|...:             ||.|:||:|..:  |.:     .|....::|.
  Rat   102 Y------WDSWYGNTQLDSVKNSSLIYYENILLGVPRVRQLRVRNSTCQVYPAFQSLASDCYNKY 160

  Fly   239 T------------YAPEWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLNYDHYGYLLNYP 291
            |            :.||||   |....:...|                        |:|::..|.
  Rat   161 TAENEDFSDFGLKHDPEWR---HSAPSSTAPW------------------------HWGFVGVYR 198

  Fly   292 EVAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQ 356
            : .||:|.:..:|.....::..||..:|:.:.|.|:|||.::|||:.|||.:|.|..|....|..
  Rat   199 D-GGYMVTLSKSKSETKAKLADLRQNNWIGRGTRAVFIDFSLYNANVNLFCIIRLLAEFPATGGI 262

  Fly   357 LPRVHVDSVSMLGNVETRSNSELLILFVYTVLVILFARGVFTKIWHHPAA-AHEAWTMVDLAIYI 420
            |......||.::..|....:.......::.:.:::|......|:....:| ....|..::|.:.:
  Rat   263 LTSWQFYSVKLIRYVSYYDHFIASCEIIFCIFLLVFITQELRKLNEFKSAYFRSVWNWIELLLLV 327

  Fly   421 L-----------NV--FLTVLAIMRDIETDALLQIIETATKGQYLDFQRPLRLHQMLFIVKGFLV 472
            |           ||  ||.:..::|..|:              |.||......|    |....::
  Rat   328 LCFLAVSFYAYCNVQCFLLLGQLLRSTES--------------YPDFYFLAYWH----IYYNNII 374

  Fly   473 CITT----LRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGITLAVPNGNNAVVFS 533
            .||.    ::::|.:.|.......:.||....:.:....::..::..|......:..|:....||
  Rat   375 AITIFFAWIKIFKFISFNETMSQLSSTLSRCMKDIVGFAIMFFIIFFAYAQLAFLVFGSQVDDFS 439

  Fly   534 HMVQSVVTCMWYSMGFNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNET-- 596
            ....|:.......:   ||.:.|.......|||.:.::..:|.:..:|:|:|.::|.|.::|.
  Rat   440 TFQNSIFAQFRIVL---GDFNFAGIQQANWILGPIYFITFIFFVFFVLLNMFLAIINDTYSEVKA 501

  Fly   597 ------------SRILKEHSNRSSITFLEFLHVEYADLFGDAFRCLRKTYESRGHTVAENVELEL 649
                        ..|:|    :|....||.|.             |||...:....:..:|:|..
  Rat   502 DYSIGRRPDFELGSIIK----KSCFNILEKLR-------------LRKAQNNEDKKMKTSVDLAQ 549

  Fly   650 NRRELIKFKRDLIKSPQELKRALLTEEQR------SADYRLRGEKLFKLMAILNLQVE 701
            .|:|  .|....|:..:::||.....|::      ..||:...::.|:.:.:..:::|
  Rat   550 ARKE--GFDESEIQEARQMKRWKERLEKKYYSTEIQDDYQPVTQQEFRELFLYAVELE 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	Polycystin_dom	171..368	CDD:466668	52/228 (23%)
		PKD_channel	369..596	CDD:462341	41/244 (17%)
Pkd2l2	XP_063133288.1	None