DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brv2 and Pkd1l1

DIOPT Version :9

Sequence 1:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_038948500.1	Gene:	Pkd1l1 / 289796	RGDID:	1564724	Length:	2586	Species:	Rattus norvegicus

Alignment Length:	471	Identity:	96/471 - (20%)
Similarity:	158/471 - (33%)	Gaps:	166/471 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 LRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVE------------NSPFGIQLPRVHVDSVS 366
            ||...|:|.:|.|:.:..|:||....|||.:||..|            ...|.|......:..:.
  Rat  2186 LRASRWIDHSTRAVSVHFTLYNPPTRLFTSVTLGAEFLSTRGLVSSSLIESFSIFYRDSALQCLL 2250

  Fly   367 MLGNVETRSNSELLILFVYTVLVILF------ARGVFTKIWHHPAAAHEAWTMVDLAIYILNVFL 425
            ||        ||||.| |..::.:.|      .:|:.: .|..|    ..|    |.:.::.|.|
  Rat  2251 ML--------SELLFL-VLNMIHLCFQLWEMATKGILS-YWRKP----RQW----LELSMVGVAL 2297

  Fly   426 TVLAIMRDIETDALLQIIETATKGQY---LDFQRPLRLHQMLFIVKGFLVCITTLRLWKVLQFAS 487
            ...|....:.|.| ..|.:...||.|   :|....:..:|....::|.|     |.|| :|:...
  Rat  2298 AYCAASGHLTTLA-ENITDQFHKGLYQRFVDISLMVSWNQRARCLQGIL-----LFLW-MLKCVH 2355

  Fly   488 VFQHF-TQTLFSAWR----AVASLGVIILVVLMAIGITLAVPNGNNAVVFSHMVQSVVTCMWYSM 547
            :|... |...|||..    .|.||.::..::|.|               .||:...::.....|.
  Rat  2356 LFSSLSTMAPFSAMMGHCPGVFSLQLVGALLLAA---------------HSHLRWFLLYTSTLSR 2405

  Fly   548 GFNGDIHPADFFHGGRILGILL------------------------YLALVFLLAIILMNVFASV 588
            |.:.:..|          |:||                        |...:|||       .|::
  Rat  2406 GTSAEAFP----------GLLLQFPGRSQKDSQHNHLESDHRAVNCYYGTLFLL-------LATL 2453

  Fly   589 IYDYFNETSRIL----KEHSNRSSIT-----------FLEFL---------------HVEYADLF 623
            .:.....||..|    |....:|.:|           .|.||               |:.|.|.|
  Rat  2454 GFRMLRATSLTLFQDRKSFHRKSLVTLKDVAVSMWHRLLTFLRLETTTSGETEVTTDHIYYLDEF 2518

  Fly   624 GDAFRCLRKTYESRGHTVAENVELELNRRELIKFKRDLIKSPQELKRALLTEEQRSAD------- 681
            ......|....:.    :::::||.:..::   ::|              |.|.|:.|
  Rat  2519 SSLLDELLMKIDG----LSDSLELSILEKQ---WRR--------------TVESRTGDSPSVGIL 2562

  Fly   682 -YRLRGEKLFKLMAIL 696
             |:..|.:.:||.:::
  Rat  2563 EYQAAGVRPYKLFSLM 2578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	71/331 (21%)
Pkd1l1	XP_038948500.1	PCC	<242..725	CDD:188093
		GPS	1398..1436	CDD:413374
		PLAT_polycystin	1504..1622	CDD:238850
		PKD_channel	2063..2389	CDD:400395	57/227 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920