Protein Alignment brv2 and PKD2L2

DIOPT Version :9

• Sequence 1: NP_648970.2
• Gene: brv2 / 39932
• FlyBaseID: FBgn0036712
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: NP_001287850.1
• Gene: PKD2L2 / 27039
• HGNCID: 9012
• Length: 624
• Species: Homo sapiens
• Alignment Length: 684
• Identity: 144/684 - (21%)
• Similarity: 250/684 - (36%)
• Gaps: 178/684 - (26%)

  Fly    82 RAEEGGPTMDHIGYLK-IRLRSLRSELLISEGHTNEMLNQKYKHIAGDLLLYGSYFIALMLMVVL 145
            |...||.:...:.|.| :.:.:...|||:                         |||.|:.:.:|
Human     6 RWHRGGASKHKLHYRKEVEITTTLQELLL-------------------------YFIFLINLCIL 45

  Fly   146 QEDHTN---YYNTNNMQRLFWDNTSVTFGLSQVYF-----IYQVHSYMKITLVEAFYAQKTNGYE 202
            .....|   ||....|..||.| |||. |..:..|     |.....:|:..|:|..|      ::
Human    46 TFGMVNPHMYYLNKVMSSLFLD-TSVP-GEERTNFKSIRSITDFWKFMEGPLLEGLY------WD 102

  Fly   203 GWWAMEQWQK-------------IGVVRLRQM--RPVDCHI-----GLGKPEWDKKTYA------ 241
            .|:..:|...             :||.|:||:  |...|.:     .|....:.|.|.|
Human   103 SWYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSN 167

  Fly   242 ------PEWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLNYDHYGYLLNYPEVAGYVVLM 300
                  .|||   :....|...|                        |:|:|..|.. .||:..:
Human   168 FGLQINTEWR---YSTSNTNSPW------------------------HWGFLGVYRN-GGYIFTL 204

  Fly   301 MSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQLPRVHVDSV 365
            ..:|.....:...||..||:.:.|..:|||.::|||:.|||.:|.|..|....|..|......||
Human   205 SKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSV 269

  Fly   366 SMLGNVETR----SNSEL---LILFVYTVLVIL----FARGVFTKIWHHPAAAHEAWTMVDLAIY 419
            .:|..|...    ::.|:   :.|||:|...:.    |....|..||:        |  ::|.:.
Human   270 KLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWN--------W--LELLLL 324

  Fly   420 ILNVFLTVLAIMRDIETDALL-QIIETATKGQYLDFQRPLRLHQMLFIVKGFLVC---------- 473
            :|...........:::...|| |::::..|  |.||.              ||.|
Human   325 LLCFVAVSFNTYYNVQIFLLLGQLLKSTEK--YSDFY--------------FLACWHIYYNNIIA 373

  Fly   474 ITT----LRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGITLAVPNGNNAVVFSH 534
            ||.    ::::|.:.|.......:.||....:.:....::..::..|......:..|:....||.
Human   374 ITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVDDFST 438

  Fly   535 MVQSVVTCMWYSMGFNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNETSRI 599
            ...|:.......:   ||.:.|.......|||.:.::..:|.:..:|:|:|.::|.|.::|   :
Human   439 FQNSIFAQFRIVL---GDFNFAGIQQANPILGPIYFITFIFFVFFVLLNMFLAIINDTYSE---V 497

  Fly   600 LKEHS--NRSSITFLEFLHVEYADLFGDAFRCLRKTYESRGHTVAENVEL-ELNRRELIKFKRDL 661
            ..::|  .|......:.:...|.::. :.|| |:|..:........:.:| |..|||  .|..:.
Human   498 KADYSIGRRLDFELGKMIKQSYKNVL-EKFR-LKKAQKDEDKKTKGSGDLAEQARRE--GFDENE 558

  Fly   662 IKSPQELKRALLTEEQRSADYRLRGEKLFKLMAI 695
            |::.:::|:           ::.|.||.:..|.|
Human   559 IQNAEQMKK-----------WKERLEKKYYSMEI 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	100/489 (20%)
PKD2L2	NP_001287850.1	PKD_channel	76..497	CDD:332708	100/486 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810