DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv2 and Loxhd1

DIOPT Version :9

Sequence 1:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_006526497.1	Gene:	Loxhd1 / 240411	MGIID:	1914609	Length:	2278	Species:	Mus musculus

Alignment Length:	308	Identity:	67/308 - (21%)
Similarity:	104/308 - (33%)	Gaps:	97/308 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 GPTMDHI-GYLKIRLRSLRSELLISEGHTNEMLNQKYKHIAGDLLLYGSYFIALMLMVVLQEDHT 150
            |||:..| |..:.|:.....||   ||...:.  ..|..:.||:...|...:
Mouse   543 GPTVRRIMGMARYRVTVCTGEL---EGAGTDA--NVYLCLFGDVGDTGERLL------------- 589

  Fly   151 NYYNTNNMQRLFWDNTSVTFGLSQVYFIYQVHSYMKITLVEAFYAQKTNGYEGWWAMEQWQKIGV 215
              ||..|...||....:..|.:..|       :..|:..|...:..|.:| .||:       :..
Mouse   590 --YNCRNNTDLFEKGNADEFTIESV-------TMRKVRRVRVRHDGKGSG-SGWY-------LDR 637

  Fly   216 VRLRQMRPVDCHIGLGKPEWDKKTYAPEWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLN 280
            |.:|:.         |:||.|...:      |..|....:|    .|..:..|..||..|..|.|
Mouse   638 VLVREE---------GQPESDNVEF------PCLRWLDKDK----DDGQLVRELLPSDSNATLKN 683

  Fly   281 YDHYGYLLNYPEVAG-------YVVLMMSTKINCLKQI-----EYLRDYSWLDKNTSALFIDLTM 333
            : .|...:...:|:|       |:.| ...|.:.:||:     ..|:||               .
Mouse   684 F-RYHISVKTGDVSGASTDSRVYIKL-YGEKSDTIKQVLLVSDNNLKDY---------------F 731

  Fly   334 YNADANLFTLITLRVENSPFGIQLPRVHV--DSVSM-----LGNVETR 374
            .....:.|||.||.:..      :.|:.:  ||..|     ||:|:.|
Mouse   732 ERGRVDEFTLETLNIGT------INRLVIGHDSTGMHAGWFLGSVQIR 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	48/225 (21%)
Loxhd1	XP_006526497.1	PLAT_repeat	43..162	CDD:238854
		PLAT_repeat	172..289	CDD:238854
		PLAT_repeat	296..414	CDD:238854
		PLAT_repeat	426..542	CDD:238854
		PLAT_repeat	554..675	CDD:238854	33/174 (19%)
		PLAT_repeat	684..805	CDD:238854	24/113 (21%)
		PLAT	816..>896	CDD:381752
		PLAT_repeat	1026..1146	CDD:238854
		PLAT_repeat	1180..1300	CDD:238854
		PLAT_repeat	1311..1437	CDD:238854
		PLAT_repeat	1465..1585	CDD:238854
		PLAT	1634..1749	CDD:381752
		PLAT_repeat	1763..1880	CDD:238854
		PLAT_repeat	1890..2010	CDD:238854
		PLAT	2023..2124	CDD:381752
		PLAT_repeat	2159..2277	CDD:238854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900