Protein Alignment brv2 and Pkdrej

DIOPT Version :9

• Sequence 1: NP_648970.2
• Gene: brv2 / 39932
• FlyBaseID: FBgn0036712
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: NP_035235.2
• Gene: Pkdrej / 18766
• MGIID: 1338786
• Length: 2126
• Species: Mus musculus
• Alignment Length: 594
• Identity: 119/594 - (20%)
• Similarity: 230/594 - (38%)
• Gaps: 128/594 - (21%)

  Fly    95 YLKIRLRSLRSELLISEGHTNEMLNQ------------KYKHIAGDLL--------------LYG 133
            |.:|||:.|..        |.|.:.|            .|:.|..|.:              |:.
Mouse  1528 YSEIRLQGLTM--------TQEEMEQLHEDIAYVRSLSMYQPITEDKIQILRRENRIRRRSFLFL 1584

  Fly   134 SY------FIALMLMVVLQEDHTN--YYNTNNMQRLFWDNTSVTFGLSQVY------FIYQVHSY 184
            ||      |:.|:|:::....|.:  |||.....|...|..:| ..|..:|      |:..:|:.
Mouse  1585 SYLVTHFIFLTLLLLLIFSLRHNDSFYYNQFIRHRFSVDLATV-MKLGDIYTWLHGVFLPLLHND 1648

  Fly   185 MKITLVEAFYAQKTNGYEGWWAMEQWQKI-GVVRLRQMR---------------------PVDCH 227
            ...|.:.                :...|| |:..:||:|                     .:.||
Mouse  1649 PNPTFLP----------------DSSSKILGLPLVRQVRARPSNKTCLLAKKFVQSSVAGEIHCH 1697

  Fly   228 IGLGKPEWDKKTYAPEWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLNYDHYGYLLNYPE 292
            ...|....|.:.|:..|.....:..........|.|           .|....|..||.|..|..
Mouse  1698 PQYGIDPEDTQHYSSVWSKAGKQSTDKASHGFTYKP-----------PGKRWVYHSYGVLNTYGS 1751

  Fly   293 VAGYVVLMM--STKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGI 355
             .|||....  ....|...:::.|...:|||:.|.|:.::||..|.|.:|...|::..|.||.|:
Mouse  1752 -GGYVFYFFPGQQMFNSTVRLKELEGKNWLDELTWAVIVELTTLNPDTSLMCSISVVFEVSPLGV 1815

  Fly   356 QLPRVHVDSVSMLGNVETRSNSELLILFVYTVLVILFARGVFTK--IWHHPAAAH--EAWTMVDL 416
            ....:.|.|.| |.:...:::||   :::|..::|.|...|..:  |.....|::  ..:.:::.
Mouse  1816 VNSSLSVYSFS-LADFNRKTSSE---IYLYAAILIFFCAYVVDEGYIIRQERASYIRSVYNLLNF 1876

  Fly   417 AIYILNVFLTVLAIMRDIETDALLQIIETATKGQYLDFQRPLRLHQMLFIVKGFLVCITTLRLWK 481
            ::..:...|.||...:......::|:. .|....::.|....|:...:.|:..||:.:|.|   |
Mouse  1877 SLKCMFALLIVLFFWKYFLATKMVQLY-LADPEAFIPFHAVSRVDHFMRIILAFLLFLTIL---K 1937

  Fly   482 VLQFASVFQHF---TQTLFSAWRAVASLGVIILV---VLMAIGITLAVPNGNNAVVFSHMVQSVV 540
            .|:::..|.:.   .:.:.:|...:....:::.:   :.:|.|..:.   |.:...:|:|:.:..
Mouse  1938 TLRYSRFFYNVRLAQKAIQAALPGICHTALVVSIYSFMYVAFGYLVF---GQHEWNYSNMIHATQ 1999

  Fly   541 TCMWYSMGFNGDIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNETSR-ILKEHS 604
            |...|.:....:..    |.|.::||:|...:.:.::..|.:|:|.:||...::|..: :.:|.|
Mouse  2000 TIFSYCVSAFQNTE----FSGNKVLGVLFLSSFMLVMICIFINLFQAVILSAYDEMKQPVYEEPS 2060

  Fly   605 NRS-SITFL 612
            :.: ::|:|
Mouse  2061 DEAEAVTYL 2069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	90/466 (19%)
Pkdrej	NP_035235.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..71
		REJ	130..598	CDD:280229
		PLAT_polycystin	1115..1230	CDD:238850
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1379..1431
		PKD_channel	1621..2051	CDD:285288	92/473 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920