DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv2 and Pkd2

DIOPT Version :9

Sequence 1:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_032887.3	Gene:	Pkd2 / 18764	MGIID:	1099818	Length:	966	Species:	Mus musculus

Alignment Length:	774	Identity:	171/774 - (22%)
Similarity:	300/774 - (38%)	Gaps:	157/774 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 DPPYR--AEEGGPTMDHIGYLKIRLRSLR---SELLISEGHTNEMLNQKY-KHIAGDLLLYGSYF 136
            ||.:|  ..||.|  ..:.:.:..:|.||   ...|:.|.:.|   .:|| |.:..:|:.|..:.
Mouse   170 DPLHRHLPLEGQP--PRVAWAERLVRGLRGLWGTRLMEESNAN---REKYLKSVLRELVTYLFFL 229

  Fly   137 IALMLMVVLQEDHTNYYNTNNMQRLFWDNTSVTFGLSQVYFIYQVHSYMKIT---LVEAFY--AQ 196
            :.|.::.........||.|..:.:||.|........:....:..:..:.|.|   .::..|  ||
Mouse   230 VVLCILTYGMMSSNVYYYTRTLSQLFIDTPVSKTEKTNFKTLSSMEDFWKFTEGSFLDGLYWKAQ 294

  Fly   197 KTNG----------YEGWWAMEQWQKIGVVRLRQMR--------PVDCHIGLGKPEWDKKTYAPE 243
            .:|.          ||.       ..:||.||||:|        |.|....: |..:|..:.:.|
Mouse   295 TSNHTQADNRSFIFYEN-------LLLGVPRLRQLRVRNGSCSIPQDLRDEI-KECYDVYSVSSE 351

  Fly   244 WRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLNYDHYGYLLNYPEVAGYVVLMMSTKINCL 308
            .|.|:...:.|.  |     ...:|.|   |||    ..|:|.:.:| ..|||.:.:..|:....
Mouse   352 DRAPFGPRNGTA--W-----MYTSEKE---LNG----SSHWGIIASY-SGAGYYLDLSRTREETA 401

  Fly   309 KQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQLPRVHVDSVSMLGNVET 373
            .|:..||...|||:.|.|.|||.::|||:.|||.::.|..|....|..:|......|.::..|..
Mouse   402 AQLAGLRRNFWLDRGTRAAFIDFSVYNANINLFCVVRLLAEFPATGGVVPSWQFQPVKLIRYVTA 466

  Fly   374 ----RSNSELLILF---VYTVLVILFARGVFTKIWHHPAAAHEAWTMVDLAIYILNVFLTVLAIM 431
                .:..|::..|   .|.|..||..|      .|..:.....|..:|:.|.:|:|...|:.|.
Mouse   467 FDFFLAACEIIFCFFIIYYVVEEILEIR------IHRLSYFRSFWNCLDVVIVVLSVVAMVINIY 525

  Fly   432 RDIETDALLQIIETATKGQYLDFQRPLRLHQMLFIVKGFLVCITTLRLWKVLQFASVFQHFTQTL 496
            |....:.|||.:|  .:..:.:|:...........:...:|.:..::|:|.:.|.......:.|:
Mouse   526 RMSNAEGLLQFLE--DQNSFPNFEHVAYWQIQFNNISAVMVFLVWIKLFKFINFNRTMSQLSTTM 588

  Fly   497 FSAWRAVASLGVIILVVLMAIGITLAVPNGNNAVVFSHMVQSVVTCMWYSMGFNGDIHPADFFHG 561
            ....:.:....::..::.:|......:..|.....||...:.:.|.....:   |||:.|:....
Mouse   589 SRCAKDLFGFTIMFSIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIIL---GDINFAEIEEA 650

  Fly   562 GRILGILLYLALVFLLAIILMNVFASVIYDYFNETSRILKEHSNRSSITFLEFLHVEYA------ 620
            .|:||.|.:...||.:..||:|:|.::|.|.::|....|.:......::.|.....:.|
Mouse   651 NRVLGPLYFTTFVFFMFFILLNMFLAIINDSYSEVKSDLAQQKAEMELSDLIRKGCQKALVKLKL 715

  Fly   621 -----DLFGDAFRC---------LRKTYESRGHTVAE----------NVELELNRRELIKFKRDL 661
                 |...::.|.         ||:..:.:|||.||          :.:.||..||..:.:.||
Mouse   716 KRNTVDAISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIFTKYDQDGDQELTEREHQQMRDDL 780

  Fly   662 IKSPQEL----------------KRALLTEEQ-----------------------------RSAD 681
            .|..::|                .|:|...|:                             |..|
Mouse   781 EKEREDLDLEHSSLPRPMSSRSFPRSLDDSEEEDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVD 845

  Fly   682 YRLR---GEKLFKLMAILNLQVEILERMVLGDKD--GKLPTPPASDSDPDDMPEMYRKR 735
             |:.   |..:.|:.|:: :::||:||..|..::  |:|....|.|:......|::|::
Mouse   846 -RMEHSIGSIVSKIDAVI-VKLEIMERAKLKRREVLGRLLDGVAEDARLGRDSEIHREQ 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	106/456 (23%)
Pkd2	NP_032887.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..179		3/8 (38%)
		PKD_channel	265..685	CDD:285288	106/453 (23%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:Q13563	639..641		0/4 (0%)
		EFh	730..776	CDD:298682	11/45 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..828		11/63 (17%)
		Linker. /evidence=ECO:0000250\|UniProtKB:Q13563	801..820		3/18 (17%)
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000250\|UniProtKB:Q13563	808..819		1/10 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	914..966
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810