DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv2 and Pkd1

DIOPT Version :9

Sequence 1:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_036016298.1	Gene:	Pkd1 / 18763	MGIID:	97603	Length:	4316	Species:	Mus musculus

Alignment Length:	790	Identity:	153/790 - (19%)
Similarity:	259/790 - (32%)	Gaps:	246/790 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GVTTCVVMVCFVLVSIFSGFMHEPQRFKTMLVTIVLVFFFQYLILEPIRFFIQSIDYA-----TW 74
            |::..:|.|. |.||.:.|....|......|::....|...:|..||::..::::.::     ..
Mouse  3573 GLSLLLVAVA-VAVSGWIGASFPPSVSVMWLLSSSSSFLASFLGWEPLKVLLEALYFSLVAKRLH 3636

  Fly    75 PQEDPPYRAEEGGPTMDHIGYLKIRLRSLRSELLI---SEGHTNEMLNQKYKHIAGDLLLYGSYF 136
            |.||...   ...|.:..:.....|:|......|.   .|....:.|:...|.    ||:|
Mouse  3637 PDEDDTL---VESPAVTPVSERVPRVRPPHGFALFLAKEEARKVKRLHDMLKR----LLVY---- 3690

  Fly   137 IALMLMVVLQEDHTNYYNTNNMQRLFWDNTSVTFGLSQVYFIYQVHSYMKITLVEAFYAQKTNGY 201
             .|.|:|.|.   .||.:.:            ..|     ..|::.|.:|..|....:...|...
Mouse  3691 -MLFLLVTLL---ANYGDAS------------CHG-----HAYRLQSAIKQELDSQAFLAITRSD 3734

  Fly   202 EGW-W----------AMEQWQKIGVVRLRQMRPVDC---------HIGLGKPEWDKKTYAPEWRL 246
            |.| |          ..:...::|..||||:|..:.         |:...........|...|:.
Mouse  3735 EFWPWMSHVFLPYVHGNQSSPELGPPRLRQVRLQEAFCPDPSSSEHMCSAAGSLSTSDYGIGWQS 3799

  Fly   247 PYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLNYDHYGYLLNYPEVAGYVVLMMSTKINCLKQI 311
            .......|   |....|.             ||...::||...| :..||:..:..:......::
Mouse  3800 VVQNGSET---WAYSAPD-------------LLGAWYWGYCAVY-DSGGYIQELGLSLEESRARL 3847

  Fly   312 EYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVE------------NSPF-------GIQL 357
            .:|:.::|||..:.|:|::||.|:....|...:|||:|            ..||       |:.|
Mouse  3848 GFLQLHNWLDSRSRAVFVELTRYSPAVGLHAAVTLRLEFPVAGHALAAFSVRPFALRRLSTGLSL 3912

  Fly   358 PRV--------------------HVDSVSMLGNVETRSNSELLILFVYTVLVILFARGVFTKIWH 402
            |.:                    ..|..:.....:|.:...|:||...|.||.|...|:..:.|.
Mouse  3913 PLLTSVCLLLFALYFSMAEVQTWRKDGCACTARPDTWARCLLVILTAATGLVRLAQLGIADRQWT 3977

  Fly   403 HPAAAH-EAWTMVDLAIYILNVFLTVLAIMRDIETDALLQIIETATKGQYLDFQRPLRLHQMLFI 466
            |....| ..:|..|....:.:|       .|.:....|..::..|.:             |:.|:
Mouse  3978 HFVQDHPRHFTSFDQVAQLGSV-------ARGLAASLLFLLLVKAAQ-------------QLRFV 4022

  Fly   467 VKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAWRAV--ASLGVIILVVLMAIGITLAVPNG--- 526
                       |.|.|         |.:||..|...:  |:||:::|.|..|....|.:.:|
Mouse  4023 -----------RQWSV---------FGKTLCRALPELMGATLGLVLLGVAYAQMAILLISSGADT 4067

  Fly   527 --NNAVVFSHMVQSVVTCMWYSMGFNGDIHPADFFHGGRILGIL----LYLALVFLLAIILMNVF 585
              |.|..|      :|.|                 .|.|:..:.    .||:.:..:.:..:.|:
Mouse  4068 LYNMARAF------LVLC-----------------PGARVPTLCPSESWYLSPLLCVGLWALRVW 4109

  Fly   586 ASVIYDYFNETSRILKEHSNRSSITFLEFLHVEYADLFGDAFRCLRKTYESRGHTVAENVELELN 650
            .::      ....||              |...|..|.|:.:   |..:|.:.:   |.|||.|.
Mouse  4110 GAL------RLGAIL--------------LRWRYHALRGELY---RPAWEPQDY---EMVELFLR 4148

  Fly   651 RREL-IKFKRDLIKSPQELKRALLTEEQRSADYRLRGEKLFKLMAILNLQVEILERMVLGDKDGK 714
            |..| :.|.:              .:|.|   :::|.|.:..|.:          |...|.|...
Mouse  4149 RLRLWMGFSK--------------VKEFR---HKVRFEGMDPLPS----------RSSRGSKSSP 4186

  Fly   715 LPTPPASDSD 724
            :..||:|.|:
Mouse  4187 VVLPPSSGSE 4196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	93/497 (19%)
Pkd1	XP_036016298.1	LRRNT	32..71	CDD:214470
		LRR_8	61..127	CDD:404697
		leucine-rich repeat	70..92	CDD:275378
		leucine-rich repeat	93..116	CDD:275378
		PCC	97..2731	CDD:188093
		leucine-rich repeat	117..129	CDD:275378
		GPS	3011..3060	CDD:413374
		PLAT_polycystin	3118..3237	CDD:238850
		PKD_channel	3726..4126	CDD:400395	92/499 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820