DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brv2 and Pkd1l1

DIOPT Version :9

Sequence 1:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	XP_036013024.1	Gene:	Pkd1l1 / 171395	MGIID:	2156538	Length:	2551	Species:	Mus musculus

Alignment Length:	811	Identity:	172/811 - (21%)
Similarity:	279/811 - (34%)	Gaps:	255/811 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 CVVMVCFVLVS-IFSGFMHEPQRFKTMLVTIVLVFFFQYLILEPIRFFIQSIDYAT--------- 73
            |:..:..:|:| :...|:.:|    .|:....|||.::.  ....:||.:|:..||
Mouse  1860 CMWWLYLLLLSLVCCAFITQP----LMICLAALVFAWKR--KHDSKFFTESLQDATKGLDLELEE 1918

  Fly    74 --------WPQEDPPYRAEEGGPTM------DHIGYL----KIRLRSLRSELLISEGHTNEMLNQ 120
                    .|....|..|||....:      .|:.:.    |.:|| :..|.|..|......|..
Mouse  1919 HSRTRVPLSPISYSPDTAEEAERVLATRQRERHLRWAQTPSKAKLR-VTGERLRRESIMQAALRD 1982

  Fly   121 KYKHIAGDLLL----YGSYFIA-LMLMVVLQEDHTNYYNTN----NMQRLFWDNTSVTFGLSQVY 176
            ...|....|||    ||.:... :.|...:::..|...|.:    :....:||.|     ||
Mouse  1983 MTTHSIMLLLLLFIAYGRFCPGEISLNHAIRKAFTRKANHSLGDLSSTEDWWDWT-----LS--- 2039

  Fly   177 FIYQVHSYMKITLVEAFYAQKTNGYEGWWAME-----QWQKIG--VVRLRQMRPVDCHIGLGKPE 234
                       ||::..|.::|:. ..|.|..     |...||  ||:|.:       |..|...
Mouse  2040 -----------TLLDELYPERTSA-RAWGAQPGALGGQCHLIGPPVVKLLK-------ISAGTAC 2085

  Fly   235 WDKKTYAP--EWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLNYDHYGYLLNYPEVAG-- 295
            ...:.::.  |..||   ||..:                       |:.::.......||..|
Mouse  2086 TPPRPFSELVEDVLP---MHSND-----------------------LDLENQNVSPGGPETCGVK 2124

  Fly   296 ---YVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQL 357
               |:..:..|:......:..||...|:|.:|.|:.:..|:||....|||.:.|..|..|.|..:
Mouse  2125 KESYMHSLGKTRHEAHAALTALRASKWIDHSTRAMSVHFTLYNPPTQLFTSVILGTECLPSGGLV 2189

  Fly   358 PRVHVDS------------VSMLGNVETRSNSELLILFVYTVLVILFARGVFTK----IWHHPAA 406
            |...|:|            :.||        ||||.|.:..:.:.....|:.||    .|..|
Mouse  2190 PSFLVESFRIFYSDSALKYLLML--------SELLFLVLNVIHLCFQLWGMTTKGILSYWRKP-- 2244

  Fly   407 AHEAW---TMVDLAI--YILNVFLTVLAIMRDIETDALLQIIETATKGQY---LDFQRPLRLHQM 463
              ..|   :||.:||  |..:..||.||:          .|.:...||.|   :|....:..||.
Mouse  2245 --RHWLELSMVGVAIAYYAASGHLTTLAV----------NITDQFHKGLYQRLVDIGLMVSWHQR 2297

  Fly   464 LFIVKGFLVCITTLRLWKVLQFASVFQHFTQ-TLFSAWRAVASLGVIILVV-------LMAIGIT 520
            ...::|.|:.:..|:...:|...|....|:. |.|..:| |..:|.::|..       |:..| |
Mouse  2298 ARCLQGILLFLWMLKYVHLLSSLSTMTPFSAVTCFPLFR-VLLVGALLLAAHYHSRWFLLFTG-T 2360

  Fly   521 LAVPNGNNAVVFSHMVQSVVTCMWYSMGFNGDIHPADFFHGGRIL----GIL-LYLALVFLLAII 580
            |:  :|.:|..|..::          :.|.|. ...|.:|  ..|    |:: .|...:|||...
Mouse  2361 LS--HGTSAEAFPGLL----------LQFPGR-SKKDSWH--NCLKSDHGVMRCYYGTLFLLLAT 2410

  Fly   581 LMNVFASVIYDYFNETSRILKEHSNRSSITFLEFLHVEYADLFGDAFRCLRKTYESRGHTVAENV 645
            |                                            .||.||.|:    .||.:|
Mouse  2411 L--------------------------------------------GFRMLRATF----LTVFQN- 2426

  Fly   646 ELELNRRELIKFKRDLIKSPQELKRAL-----LTEEQRSADY--------RLRGEKLFKLMAIL- 696
            ....:|:.|:..|...:.:..::...|     |.|.:.:.|:        .|..|.|.|:..:.
Mouse  2427 RKSSHRKPLVTLKDIAVYTWHKVLTLLGLETTLEETEVATDHIYYLDEFSSLLDELLMKIDGLSD 2491

  Fly   697 NLQVEILE---RMVLGDKDGKLPTPPASDSD 724
            :|::.|||   :..|..:.|  .:||...|:
Mouse  2492 SLELSILENQWKRALESRAG--DSPPVGSSE 2520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	105/477 (22%)
Pkd1l1	XP_036013024.1	PCC	<167..622	CDD:188093
		REJ	<835..976	CDD:366875
		GPS	1387..1425	CDD:413374
		PLAT	1493..1611	CDD:412108
		PKD_channel	2023..>2331	CDD:400395	84/382 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S9099
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770