Protein Alignment brv2 and PKD1L1

DIOPT Version :9

• Sequence 1: NP_648970.2
• Gene: brv2 / 39932
• FlyBaseID: FBgn0036712
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: XP_016867287.1
• Gene: PKD1L1 / 168507
• HGNCID: 18053
• Length: 2920
• Species: Homo sapiens
• Alignment Length: 690
• Identity: 142/690 - (20%)
• Similarity: 248/690 - (35%)
• Gaps: 183/690 - (26%)

  Fly    97 KIRLRSLRSELLISEGHTNEMLNQKYKHIAGDLLLYGSYFIALMLMVVLQEDHTNYYNTNN-MQR 160
            |.:||..|..:. .|..|...|    :.|:.|:|:     :.|:|.|:......:.|:.|. :::
Human  2323 KAQLRGTRQRMR-RESRTRAAL----RDISMDILM-----LLLLLCVIYGRFSQDEYSLNQAIRK 2377

  Fly   161 LFWDNTSVTFGLSQVYFIYQVHSYMKITLVEAFY-----AQKTNGYEGWWAMEQWQKIGVVRLRQ 220
            .|..|.....|  .:..|.....:...||::..|     :.:..|.:......:...||...:||
Human  2378 EFTRNARNCLG--GLRNIADWWDWSLTTLLDGLYPGGTPSARVPGAQPGALGGKCYLIGSSVIRQ 2440

  Fly   221 MRPVDCHIGLGKP--------EWDKKTYAPEWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGL 277
            ::....|  |.||        |....|.:||...|.                          |..
Human  2441 LKVFPRH--LCKPPRPFSALIEDSIPTCSPEVGGPE--------------------------NPY 2477

  Fly   278 LLNYDHYGYLLNYPEVAG----YVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADA 338
            |::.::....||.|...|    .|:.:..|:......:..||...|:|::|.|:.:..|:||...
Human  2478 LIDPENQNVTLNGPGGCGTREDCVLSLGRTRTEAHTALSRLRASMWIDRSTRAVSVHFTLYNPPT 2542

  Fly   339 NLFTLITLRVENSPFGIQLPRVHVDSVSMLGNVETRSNSELLILFVYTVLVIL------------ 391
            .|||.::||||..|.|..:|...|:|.|:.     ||:|.|....:...||.|
Human  2543 QLFTSVSLRVEILPTGSLVPSSLVESFSIF-----RSDSALQYHLMLPQLVFLALSLIHLCVQLY 2602

  Fly   392 --FARGVFTKIWHHPAAAHEAWTMVDLAIYILNVFLTVLAIMRDIET---DALLQIIETATKGQY 451
              ..:||.: .|..|    ..|    |.:.::.|.||..|:...:.|   |...|......:. :
Human  2603 RMMDKGVLS-YWRKP----RNW----LELSVVGVSLTYYAVSGHLVTLAGDVTNQFHRGLCRA-F 2657

  Fly   452 LDFQRPLRLHQMLFIVKGFLVCITTLRLW-------KVLQFASVFQHFTQTLFSAWRAVASL-GV 508
            :|.......:|....::|.|:.:.||:..       .:...:|:.:|...::|     ||.| |.
Human  2658 MDLTLMASWNQRARWLRGILLFLFTLKCVYLPGIQNTMASCSSMMRHSLPSIF-----VAGLVGA 2717

  Fly   509 IILVVLMAIGITLAVPNGNNAVVFSHMVQSVVTCMW-YSMGFNGDIHPADFFHGGR------ILG 566
            ::|..|                  ||:.:.::: || ...|...|..|...||..|      :||
Human  2718 LMLAAL------------------SHLHRFLLS-MWVLPPGTFTDAFPGLLFHFPRRSQKDCLLG 2763

  Fly   567 ILLYLALVFLLAIILMNVFASVIYDYFNETSRILKEHSNRSSITFLEFLHVEYADL-FGDAFRCL 630
                                             |.:...|:...:...|.:..|.| ||.....|
Human  2764 ---------------------------------LSKSDQRAMACYFGILLIVSATLCFGMLRGFL 2795

  Fly   631 ------RKTYESRGHTVAENVELELNRRELIKFKRDLIKSPQELKRALLTEEQRSADY------R 683
                  ||:::|:.....::|...: ..:::.|.|  :::| :|:.|.:.|..   :|      .
Human  2796 MTLPQKRKSFQSKSFVRLKDVTAYM-WEKVLTFLR--LETP-KLEEAEMVENH---NYYLDEFAN 2853

  Fly   684 LRGEKLFKLMAIL-NLQVEILERMVLGDKDGKLPTPPASD 722
            |..|.|.|:..:. :||:.:||:......:.:....|..|
Human  2854 LLDELLMKINGLSDSLQLPLLEKTSNNTGEARTEESPLVD 2893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	96/475 (20%)
PKD1L1	XP_016867287.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S9099
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770