DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv2 and PKD1L2

DIOPT Version :9

Sequence 1:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_443124.3	Gene:	PKD1L2 / 114780	HGNCID:	21715	Length:	2459	Species:	Homo sapiens

Alignment Length:	671	Identity:	146/671 - (21%)
Similarity:	263/671 - (39%)	Gaps:	134/671 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 GVTTCVVMVCFVLVSIFSGFMHEPQRFKTM--------------LVTIVLVFFFQYLILEPIR-- 63
            |:....::|.::||:..||.    ..|.||              |:::.:.|.....:.:|::
Human  1816 GLPWWCILVGWLLVAATSGV----AAFFTMLYGLHYGRASSLRWLISMAVSFVESMFVTQPLKVL 1876

  Fly    64 ----FF---IQSIDYATWPQED--PPYRAEEGGPTMDHIGYLKIRLRSLRS------ELLISEGH 113
                ||   ::.:|    .:||  .|......||  |.....:.|..|.|.      ...|.:..
Human  1877 GFAAFFALVLKRVD----DEEDTVAPLPGHLLGP--DPYALFRARRNSSRDVYQPPLTAAIEKMK 1935

  Fly   114 TNEMLNQKYKHIAGDLLLYGSYFIALMLMVVLQEDHTNYYNTNNMQRLFWDNTSVTFGLSQVYFI 178
            |..:..||...:..::|.|..:...|:|:...|.|.:.|:...::|..|      |.|.|.|...
Human  1936 TTHLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQHSF------TRGFSGVLGF 1994

  Fly   179 YQVHSYMKITLVEAFYAQK----TNGYEGWWAMEQWQKIGVVRLRQMRPVDCHIGLGKPEWDKKT 239
            .:...:...|||...|...    |:|..        :.:|..::||:|..:....|.:   ..:.
Human  1995 REFFKWANTTLVSNLYGHPPGFITDGNS--------KLVGSAQIRQVRVQESSCPLAQ---QPQA 2048

  Fly   240 YAPEWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLN------------YDHYGYLLNYPE 292
            |....|.||.           .|....|::...: |...|:            |..:|.|..| .
Human  2049 YLNGCRAPYS-----------LDAEDMADYGEGW-NATTLSEWQYQSQDQRQGYPIWGKLTVY-R 2100

  Fly   293 VAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQL 357
            ..||||.:.:.:.:..:.:.||.|.:|||..|.|:|::.|:|||:.|||.::||.:|.|..|...
Human  2101 GGGYVVPLGTDRQSTSRILRYLFDNTWLDALTRAVFVESTVYNANVNLFCIVTLTLETSALGTFF 2165

  Fly   358 PRVHVDSVSML----GNVETRSNSELLILFVYTVLVILFARGVFTKIWHHPAAAHEAWTMVDLAI 418
            ....:.|:.:.    |.......:||:........:::..:.:..:.|.:..:   .|.:::|||
Human  2166 THAALQSLRLYPFTDGWHPFVVAAELIYFLFLLYYMVVQGKRMSKETWGYFCS---KWNLLELAI 2227

  Fly   419 YI-----LNVFL--TVLAIMRDIE-----TDALLQIIETATKGQYLDFQRPLRLHQMLFIVKGFL 471
            .:     |.||:  .||| .||::     .:..:...|||.....|.:            :..||
Human  2228 ILASWSALAVFVKRAVLA-ERDLQRCRNHREEGISFSETAAADAALGY------------IIAFL 2279

  Fly   472 VCITTLRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILVVLMAIGITLAVPNGNNAVVFSHMV 536
            |.::|::||.:|:........|..|..||..::...::||.:|:|..|...:..|.....:..:.
Human  2280 VLLSTVKLWHLLRLNPKMNMITAALRRAWGDISGFMIVILTMLLAYSIASNLIFGWKLRSYKTLF 2344

  Fly   537 QSVVTCMWYSMG-FNG----DIHPADFFHGGRILGILLYLALVFLLAIILMNVFASVIYDYFNET 596
            .:..|.:...:| ||.    |..|        :||..|..:.:..:..:::|:|.|||...|:|.
Human  2345 DAAETMVSLQLGIFNYEEVLDYSP--------VLGSFLIGSCIVFMTFVVLNLFISVILVAFSEE 2401

  Fly   597 SRI--LKEHSNRSSITFLEFL 615
            .:.  |.|......:..::.|
Human  2402 QKYYQLSEEGEIVDLLLMKIL 2422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	105/463 (23%)
PKD1L2	NP_443124.3	CLECT	28..153	CDD:214480
		Gal_Lectin	170..251	CDD:307994
		GPS	1280..1319	CDD:197639
		PLAT_polycystin	1390..1509	CDD:238850
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1625..1649
		PKD_channel	1987..2400	CDD:332708	104/460 (23%)
		Channel pore-region	2340..2362		4/21 (19%)
		Interaction with GNAS and GNAI1. /evidence=ECO:0000269\|PubMed:15203210	2379..2459		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2431..2459
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5261
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.050