DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv2 and PKDREJ

DIOPT Version :9

Sequence 1:	NP_648970.2	Gene:	brv2 / 39932	FlyBaseID:	FBgn0036712	Length:	736	Species:	Drosophila melanogaster
Sequence 2:	NP_006062.1	Gene:	PKDREJ / 10343	HGNCID:	9015	Length:	2253	Species:	Homo sapiens

Alignment Length:	680	Identity:	137/680 - (20%)
Similarity:	267/680 - (39%)	Gaps:	145/680 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 CVVMVCFVLVS---------IFSGFMHEPQRFKTMLVTIVLVFFFQYLILEPIRFFIQSIDYATW 74
            ||.:..|::.:         :|.|..:...:....|......|....|:::|.:..:.| .:.|
Human  1576 CVYVAWFLVFATSSISSFFIVFYGLTYGYDKSIEWLFASFCSFCQSVLLVQPSKIILLS-GFRT- 1638

  Fly    75 PQEDPPYRAEEGGPTMDHIGYLKIRLRSLRSELLISEGHTNEM---------------------- 117
              ..|.|.......|  ...|.:|||..:|.       |..||
Human  1639 --NKPKYCKNLSWST--KYKYTEIRLDGMRM-------HPEEMQRIHDQIVRIRGTRMYQPLTED 1692

  Fly   118 ---LNQKYKHIAGDLLLYGSY------FIALMLMVVLQEDHTN--YYNTNNMQRLFWDNTSVTFG 171
               :.::.|.|....||:.||      |:||:|::::...||:  |||.....|...|..:|| .
Human  1693 EIRIFKRKKRIKRRALLFLSYILTHFIFLALLLILIVLLRHTDCFYYNQFIRDRFSMDLATVT-K 1756

  Fly   172 LSQVYFIYQVHSYMKITLVEAFYAQKTNGYEGWWAMEQWQKI-GVVRLRQM-------------- 221
            |..:|      .::...|:...:    |.....:..|...|| |:..:||:
Human  1757 LEDIY------RWLNSVLLPLLH----NDLNPTFLPESSSKILGLPLMRQVRAKSSEKMCLPAEK 1811

  Fly   222 -------RPVDCHIGLGKPEWDKKTYAPEWRLPYHRMHYTEKFWRIYDPFVPAE------FEPS- 272
                   |.:.||...|....|.|.|:              .||...|.....|      ::|.
Human  1812 FVQNSIRREIHCHPKYGIDPEDTKNYS--------------GFWNEVDKQAIDESTNGFTYKPQG 1862

  Fly   273 -----FLNGLLLNYDHYGYLLN-YPEVAGYVVLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDL 331
                 :..|||..|...||.|. :||         ..:.|...:::.|::.:|||:.|.|:.::|
Human  1863 TQWLYYSYGLLHTYGSGGYALYFFPE---------QQRFNSTLRLKELQESNWLDEKTWAVVLEL 1918

  Fly   332 TMYNADANLFTLITLRVENSPFGIQLPRVHVDSVSMLGNVETRSNSELLILFVYTVLVILFARGV 396
            |.:|.|.|||..|::..|.|..|:....:.:.|.| |.:.:.::::|   :::|..::|.|...|
Human  1919 TTFNPDINLFCSISVIFEVSQLGVVNTSISLHSFS-LADFDRKASAE---IYLYVAILIFFLAYV 1979

  Fly   397 FTK----IWHHPAAAHEAWTMVDLAIYILNVFLTVLAIMRDIETDALLQIIETATKGQYLDFQRP 457
            ..:    :....:.....:.:::.|:..:...|.||.:.:......:::.. .:....::.|...
Human  1980 VDEGCIIMQERASYVRSVYNLLNFALKCIFTVLIVLFLRKHFLATGIIRFY-LSNPEDFIPFHAV 2043

  Fly   458 LRLHQMLFIVKGFLVCITTLRLWKVLQFASVFQHFTQTLFSAWRAVASLGVIILV---VLMAIGI 519
            .::..::.|:.|||:.:|.|:..:..:|....:...:.:.:|...:..:..::.|   |.||.|.
Human  2044 SQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMAFVVSVYFFVYMAFGY 2108

  Fly   520 TLAVPNGNNAVVFSHMVQSVVTCMWYSMGFNGDIHPADFFHGGRILGILLYLALVFLLAIILMNV 584
            .:.   |.:...:|:::.|..|...|.:....:..    |...||||:|...:.:.::..:|:|:
Human  2109 LVF---GQHEWNYSNLIHSTQTVFSYCVSAFQNTE----FSNNRILGVLFLSSFMLVMICVLINL 2166

  Fly   585 FASVIYDYFNETSR-ILKEHSNR-SSITFL 612
            |.:||...:.|..: :.:|.|:. .::|:|
Human  2167 FQAVILSAYEEMKQPVYEEPSDEVEAMTYL 2196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	92/468 (20%)
PKDREJ	NP_006062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..177
		REJ	243..711	CDD:280229
		GPS	1100..1166	CDD:295363
		PLAT_polycystin	1231..1346	CDD:238850
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1494..1562
		PKD_channel	1748..2178	CDD:285288	94/475 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920