Protein Alignment brv2 and pkd1

DIOPT Version :9

• Sequence 1: NP_648970.2
• Gene: brv2 / 39932
• FlyBaseID: FBgn0036712
• Length: 736
• Species: Drosophila melanogaster
• Sequence 2: XP_017952982.2
• Gene: pkd1 / 100494429
• XenbaseID: XB-GENE-483409
• Length: 4354
• Species: Xenopus tropicalis
• Alignment Length: 646
• Identity: 140/646 - (21%)
• Similarity: 266/646 - (41%)
• Gaps: 151/646 - (23%)

  Fly    11 LTCFGVTTCVVMVCFVLVSIFS--GFMHEPQRFKTMLVTIVLVFFFQYLILEPIRFFIQSIDYAT 73
            |:||.:..|..:..::.|...|  |.|        .|::.:..|...:.||||::...:::.:|.
 Frog  3546 LSCFLLLCCFAVSSWIGVGFTSSVGLM--------WLISGIFSFLCSFFILEPLKVLFEALYFAL 3602

  Fly    74 WPQEDPPYRAEEGG----PTMDHIGYLKIRLRSLRSELLI---SEGHTNEMLNQKYKHIAGDLLL 131
            ..:...|  .||..    |.::.:.....::|..:...|.   .|....::|::..|    :||:
 Frog  3603 VAKRLHP--EEEDTLVECPIVEQVSERITKVRPPQGFALFQAREEAQKVKLLHRMLK----NLLV 3661

  Fly   132 YGSYFIALMLMVVLQEDHTNYYNT--NNMQRLFWDNTSVTFGLSQVYFIYQVHSYMKITLVEAFY 194
            :..:|:.:::        |||...  ||...|...:.|...|         .|.::.|...:.|:
 Frog  3662 FMLFFLVILI--------TNYGEAPKNNSAYLLQRSISQELG---------THKFLHIKRSDEFW 3709

  Fly   195 AQKTNGYEGWWAMEQW---------------QKIGVVRLRQMR-----PVDCHIGLGKPEWDKKT 239
            .         ||.|..               ..:||.||||:|     |..|.:.|    :....
 Frog  3710 V---------WASEMLLPYVHHNQPLQQGYSSMLGVARLRQIRLKEALPTSCSLQL----FSAGR 3761

  Fly   240 YAPEWRLPYHRMHYTEKFWRIYDPFVPAEFEPSFLNGLLLNY---DH----YGYLLNYPEVAGYV 297
            ..||                ::|   .|.|:.:.|..|..:|   ||    |...|::.:.:|||
 Frog  3762 SCPE----------------LFD---DAIFKSATLPSLNWSYSPPDHTGAWYWGFLSFYDTSGYV 3807

  Fly   298 VLMMSTKINCLKQIEYLRDYSWLDKNTSALFIDLTMYNADANLFTLITLRVENSPFGIQLPRVHV 362
            .|:..::.:..:.:|.|:...|:|..|.|||::.::|:....|:..:||.:|....|..||.|::
 Frog  3808 QLLQGSQKDNEELLEELQQSYWIDNLTRALFVEFSLYSPGVELYASVTLLLEFPLAGRALPSVNI 3872

  Fly   363 DSVSMLGNVETRSNSELLILF--------VYTVL---VILFARGV--FTKIWHHPAAAHEAWTMV 414
            .:..:|   ...|.:.||::.        ||.||   :|:...|:  ||:.|:     :..|.:.
 Frog  3873 RAFPLL---RLTSGTHLLLVMMVFLMMFVVYFVLSECLIIRKEGLQYFTRFWN-----YVQWLLT 3929

  Fly   415 DLAIYILNVFLTVLAIMRDIETDALLQIIETATKGQYLDFQRPLRLHQMLFIVKGF------LVC 473
            .||:..:.|:|: .|.:.|.:.|..|:           |.:..:.|:|:.|:...|      ::.
 Frog  3930 VLAVCTVVVYLS-KASLADRQWDRYLK-----------DKEAFVSLYQVGFLGNTFHSLSASILF 3982

  Fly   474 ITTLRLWKVLQFASVFQHFTQTLFSAWRAV-ASLGVI--ILVVLMAIGITLAVPNGNNAVVFSHM 535
            :.|::..:.::|...:..|.:||..|.|.: |:.|.:  :::|...:|..|...:...   |...
 Frog  3983 VLTVKAAQQMRFIREWSAFGKTLSLAARELCAASGAVFGLVLVYAQLGFLLFSSSWEK---FHSF 4044

  Fly   536 VQSVVTCMWYSMGFNGDIHPADFFHGGRILGILLYLALVFLLAI-ILMNVFASVIYDYFNE 595
            ..|::|....:.| |..: .|.|.:...|..  ||.|...:|.: ||:.:||:|:.:.:.:
 Frog  4045 GSSILTLFAVARG-NVSL-KAPFPYSSTISH--LYFASYLVLEVWILLRLFAAVLINSYRQ 4101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv2	NP_648970.2	PKD_channel	169..596	CDD:285288	106/477 (22%)
pkd1	XP_017952982.2	LRR_8	<83..114	CDD:404697
		leucine-rich repeat	83..103	CDD:275378
		leucine-rich repeat	104..127	CDD:275378
		PCC	108..2722	CDD:188093
		leucine-rich repeat	128..140	CDD:275378
		GPS	2996..3045	CDD:413374
		PLAT_polycystin	3103..3222	CDD:238850
		PKD_channel	3699..4102	CDD:400395	104/462 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010